El proper dijous 13 d'abril de 2023, a les 12.00h, l'Aula 14, Dolors aleu i Riera del Campus Clínic acollirà el dotzè dels seminari del Cicle Continuat de Conferències de la Facultat de Medicina i Ciències de la Salut.
El seminari porta per títol "Paving the RHOadwith new molecular mechanisms of brain development" i estarà a càrrec del Dr. Joaquim Egea, PhD, Professor and Groupleader del Institut de Recerca Biomédica de la Universitat de Lleida.
Aquest seminari, esta adreçat a tot el PDI de la Facultat de Medicina i Ciències de la Salut i els diferents centres de recerca de Barcelona i no requereixen inscripció prèvia per poder assistir-hi.
A continuació trobareu una breu sinopsi dels temes que abordarà el Dr. Egea durant el seminari:
His group isinterested in the development of the cerebral cortex and the cellular (main lyax on guidance and neuron migration) and molecular mechanisms involved. The cerebral cortex is the largest region of the brain in humans, subjected to a dramatic expansion during evolution and responsible for our higher cognitive capabilities. On the other hand, cortical malformation is at the basis of several neuropathological conditions such as schizophrenia, autism, mentalretardation and epilepsy. His main research focuses on the study of the Fibronectin and Leucine Rich Transmembrane proteins (FLRT1/2/3). During the last past years, they have contributed to the growing evidence of the extraordinary versatility of these proteins, especially in cortex development, and their diverse mechanisms of action. They have studied a candidate downstream effector of FLRTs, the RhoGTPase Rnd3/RhoE. The main feature of Rnds is their very low GTPase activity and therefore they are always bound to GTP and a reconsidered constitutive active proteins. Therefore, the regulation of their activity depends on other mechanisms such as gene transcription, protein stability, subcellular localization and phosphorylation. Using complex transgenic mouse models, immunofluorescence, tracing experiments and explant assays we have made two important and unexpected observations: 1)thatRnd3/RhoE is crucial for the correct projection of TCAs and striatal axons (SAs) in a non-cell autonomous manner since the primary requirement of Rnd3/RhoE is for the development of structures derived from the Medial Ganglionic Eminence (MGE) such as the Globus Pallidus (GP) and2) that Rnd3/RhoE plays a key role in the control of mammalian cerebral cortex development. These two observations are particularly important because examples of intracellular signaling effectors involved in these processes are rather sparse.
Us hi esperem!
