One of the most confusing aspects for patients with type 2 diabetes mellitus is that they have high fasting glucose levels. This is because in these insulin-resistant patients, glucose production by the liver is triggered, a process that is still full of questions for the scientific community. Now, a review article published in the journal Trends in Endocrinology & Metabolism presents a comprehensive overview of the most important advances in understanding this mechanism. It also helps to identify new drug targets in the fight against type 2 diabetes mellitus, which the World Health Organization (WHO) considers one of the pandemics of the 21^st century.

The study is led by Professor Manuel Vázquez-Carrera, from the Faculty of Pharmacy and Food Sciences of the University of Barcelona, the UB Institute of Biomedicine (IBUB), the Sant Joan de Déu Research Institute (IRSJD) and the Centre for Biomedical Research Network on Diabetes and Associated Metabolic Diseases (CIBERDEM). Among the participants in the study are the experts Emma Barroso, Javier Jurado-Aguilar and Xavier Palomer (UB-IBUB-IRJSJD-CIBERDEM) and Professor Walter Wahli, from the University of Lausanne (Switzerland).

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