Publicacions recents

Unraveling Molecular Pathways Altered in MeCP2-Related Syndromes, in the Search for New Potential Avenues for Therapy.

AA Castells, R Balada, A Tristán-Noguero, M O’Callaghan, E Cortès-Saladelafont, A Pascual-Alonso, A Garcia-Cazorla, J Armstrong and Soledad Alcántara.2021. Biomedicines, 9, 148. https://doi.org/10.3390/biomedicines9020148.

Synaptic PTEN in Symptomatic Alzheimer

Díaz González M, Buberman A, Morales M, Ferrer I, Knafo S. Aberrant 

Front Synaptic Neurosci. 2021 May 11;13:683290. doi: 10.3389/fnsyn.2021.683290. PMID: 34045952; PMCID: PMC8144462.

 

Berbel D, Càmara J, González-Díaz A, Cubero M, López de Egea G, Martí S, Tubau F, Domínguez MA, Ardanuy C. 

J Antimicrob Chemother. 2021 May 20:dkab130. doi: 10.1093/jac/dkab130. Epub ahead of print. PMID: 34015100.

 

The gene silencing of IRF5 and BLYSS effectively modulates the outcome of experimental lupus nephritis.

Guiteras J, Ripoll É, Bolaños N, De Ramon L, Fontova P, Lloberas N, Cruzado JM, Aràn JM, Aviñó A, Eritja R, Gomà M, Taco R, Grinyó JM, Torras J. 

Mol Ther Nucleic Acids. 2021 Apr 2;24:807-821. doi: 10.1016/j.omtn.2021.03.019. PMID: 33996261; PMCID: PMC8105598.

 

Investigating the Role of Guanosine on Human Neuroblastoma Cell Differentiation and the Underlying Molecular Mechanisms.

Belluardo N, Mudò G, Di Liberto V, Frinchi M, Condorelli DF, Traversa U, Ciruela F, Ciccarelli R, Di Iorio P, Giuliani P.

Front Pharmacol. 2021 Apr 27;12:658806. doi: 10.3389/fphar.2021.658806. PMID: 33986683; PMCID: PMC8111303.

Piano-Stool Ruthenium(II) Complexes with Delayed Cytotoxic Activity: Origin of the Lag Time.

Rafols L, Josa D, Aguilà D, Barrios LA, Roubeau O, Cirera J, Soto-Cerrato V, Pérez-Tomás R, Martínez M, Grabulosa A, Gamez P. Piano-Stool 

 Inorg Chem. 2021 May 12. doi: 10.1021/acs.inorgchem.1c00507. Epub ahead of print. PMID: 33979132.

Guerrero-Pérez F, Peiró I, Marengo AP, Teulé A, Ruffinelli JC, Llatjos R, Serrano T, Macia I, Vilarrasa N, Iglesias P, Villabona C. 

Rev Endocr Metab Disord 2021 May 7. doi: 10.1007/s11154-021-09660-2. Epub ahead of print. PMID: 33961211.

Jimenez-Marin A, Diez I, Labayru G, Sistiaga A, Caballero MC, Andres-Benito P, Sepulcre J, Ferrer I, Lopez de Munain A, Cortes JM. 

Neuropathol Appl Neurobiol. 2021 May 5. doi: 10.1111/nan.12725. Epub ahead of print. PMID: 33955002.

Raymond Y, Pastorino D, Ginebreda I, Maazouz Y, Ortiz M, Manzanares MC,

Clin Oral Investig. 2021 May 1. doi: 10.1007/s00784-021-03956-y. Epub ahead of print. PMID: 33931811.

The casual Role

Jové M, Mota-Martorell N, Torres P, Ayala V, Portero-Otin M, Ferrer I, Pamplona R. 

Disease Pathology. Life (Basel). 2021 Apr 25;11(5):388. doi: 10.3390/life11050388. PMID: 33923074; PMCID: PMC8147054.

Ramírez-Nuñez O, Jové M, Torres P, Sol J, Fontdevila L, Romero-Guevara R,

Andrés-Benito P, Ayala V, Rossi C, Boada J, Povedano M, Ferrer I, Pamplona R,

Portero-Otin M. 

J Neurochem. 2021 Apr 27. doi: 10.1111/jnc.15373. Epub ahead of print. PMID: 33905537.

Videla-Cés M, Romero-Pijoan E, Sales-Pérez JM, Sánchez-Navés R, Pallarés N,Videla S;

Injury. 2021 Apr 9:S0020-1383(21)00330-2. doi: 10.1016/j.injury.2021.04.021. Epub ahead of print. PMID: 33875249.

 

Ortiz-Miguel S, Miguel-Pérez M, Navarro J, Möller I, Pérez-Bellmunt A, Agullo JL, Ortiz-Sagristà J, Blasi J, Martinoli C. 

Surg Radiol Anat. 2021 Apr 5. doi: 10.1007/s00276-021-02736-3. Epub ahead of print. PMID: 33818623.

Adenosine A<sub>2A</sub> Receptors Are Upregulated in Peripheral Blood Mononuclear Cells from Atrial Fibrillation Patients.

Godoy-Marín H, Duroux R, Jacobson KA, Soler C, Colino-Lage H, Jiménez-Sábado V, Montiel J, Hove-Madsen L, Ciruela F. 

Int J Mol Sci. 2021 Mar 27;22(7):3467. doi: 10.3390/ijms22073467. PMID: 33801676; PMCID: PMC8036820.

Herraiz-Martínez A, Tarifa C, Jiménez-Sábado V, Llach A, Godoy-Marín H, Colino H, Nolla-Colomer C, Casabella S, Izquierdo-Castro P, Benítez I, Benítez R, Roselló-Díez E, Rodríguez-Font E, Viñolas X, Ciruela F, Cinca J, 

Cardiovasc Res. 2021 Mar 31:cvab127. doi: 10.1093/cvr/cvab127. Epub ahead of print. PMID: 33788918.

 

Atypical astroglial pTDP-43 pathology in astroglial predominant tauopathy.

Gelpi E, Aldecoa I, Lopez-Villegas D, Abellan-Vidal MT, Mercadel-Fañanas P, Fortea J, Ribosa R, Morenas E, Gomez-Anson B, Molina-Porcel L, Ximelis T, Borrego S, Antonell A, Rovelet-Lecrux A, Klotz S, Andres-Benito P, Sanchez-Valle R, Ferrer I. 

Neuropathol Appl Neurobiol. 2021 Mar 17. doi: 10.1111/nan.12707. Epub ahead of print. PMID: 33730418.

Perioral Aerosol

Sequestration Suction Device Effectively Reduces Biological Cross-Contamination in Dental Procedures.

 

Lloro V, Giovannoni ML, Luaces VL, Manzanares MC. 

Eur J Dent. 2021 Mar 12. doi: 10.1055/s-0041-1724152. Epub ahead of print. PMID: 33711845.

Prognostic value of the preoperative lymphocyte-to-monocyte ratio for survival after lung cancer surgery.

Ramos R, Macía I, Navarro-Martin A, Déniz C, Rivas F, Ureña A, Masuet- Aumatell C, Moreno C, Nadal E, Escobar I. 

BMC Pulm Med. 2021 Mar 2;21(1):75. doi: 10.1186/s12890-021-01446-1. PMID: 33653309; PMCID: PMC7927224.

 

Pons-Espinal M, Blasco-Agell L, Consiglio A. 

Cell Mol Life Sci. 2021 Mar;78(5):2081-2094. doi: 10.1007/s00018-020-03700-x. Epub 2020 Nov 18. PMID: 33210214; PMCID: PMC7966189.

Almeida-Santos D, Duarte AC, Gonçalves I, Ferreira CL, Ferrer I, Ishikawa H, Schwerk C, Schroten H, Santos CRA

J Mol Neurosci. 2021 Mar;71(3):625-637. doi: 10.1007/s12031-020-01684-8. Epub 2020 Aug 20. PMID: 32816235.

Dumbović G, Sanjuan X, Perucho M, Forcales SV. 

Methods. 2021 Mar;187:68-76. doi: 10.1016/j.ymeth.2020.04.009. Epub 2020 Apr 30. PMID: 32360441.

 

Marimon JM, Ardanuy C. 

Enferm Infecc Microbiol Clin (Engl Ed). 2021 Mar;39(3):142-150. English, Spanish. doi: 10.1016/j.eimc.2020.02.016. Epub 2020 Mar 27. PMID: 32229129.

Identification of a targetable KRAS-mutant epithelial population in non-small cell lung cancer

Maroni G, Bassal MA, Krishnan I, Fhu CW, Savova V, Zilionis R, Maymi VA, Pandell N, Csizmadia E, Zhang J, Storti B, Castaño J, Panella R, Li J, Gustafson CE, Fox S, Levy RD, Meyerovitz CV, Tramontozzi PJ, Vermilya K, De Rienzo A, Crucitta S, Bassères DS, Weetall M, Branstrom A, Giorgetti A, Ciampi R, Del Re M, Danesi R, Bizzarri R, Yang H, Kocher O, Klein AM, Welner RS, Bueno R, Magli MC, Clohessy JG, Ali A, Tenen DG, Levantini E. 

Commun Biol. 2021 Apr 14;4(1):370. doi: 10.1038/s42003-021-01897-6. PMID: 33854168; PMCID:

PMC8046784.

Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression

https://www.nature.com/articles/s41419-021-03638-3

Single loss of a Trp53 allele triggers an increased oxidative, DNA damage and cytokine inflammatory responses through deregulation of IκBα expression.

Marruecos L, Manils J, Moreta C, Gómez D, Filgaira I, Serafin A, Cañas X, Espinosa L, Soler C

Cell Death Dis. 2021 Apr 6;12(4):359.

 

Autophagy . 2021 Feb 8;1-382. doi: 10.1080/15548627.2020.1797280. Online ahead of print. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

1: Valle-León M, Callado LF, Aso E, Cajiao-Manrique MM, Sahlholm K, López-Cano
M, Soler C, Altafaj X, Watanabe M, Ferré S, Fernández-Dueñas V, Menchón JM,
Ciruela F. Decreased striatal adenosine A<sub>2A</sub>-dopamine D<sub>2</sub>
receptor heteromerization in schizophrenia. Neuropsychopharmacology. 2021
Feb;46(3):665-672. doi: 10.1038/s41386-020-00872-9. Epub 2020 Oct 3. PMID:
33010795.

2: Almeida-Santos D, Duarte AC, Gonçalves I, Ferreira CL, Ferrer I, Ishikawa H,
Schwerk C, Schroten H, Santos CRA. Cadaverine and Spermine Elicit
Ca<sup>2+</sup> Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1
Dependent Pathway. J Mol Neurosci. 2021 Mar;71(3):625-637. doi:
10.1007/s12031-020-01684-8. Epub 2020 Aug 20. PMID: 32816235.

3: Dumbović G, Sanjuan X, Perucho M, Forcales SV. Stimulated emission depletion
(STED) super resolution imaging of RNA- and protein-containing domains in fixed
cells. Methods. 2021 Mar;187:68-76. doi: 10.1016/j.ymeth.2020.04.009. Epub 2020
Apr 30. PMID: 32360441.

4: Santos-Gómez A, Miguez-Cabello F, García-Recio A, Locubiche-Serra S, García-
Díaz R, Soto-Insuga V, Guerrero-López R, Juliá-Palacios N, Ciruela F, García-
Cazorla À, Soto D, Olivella M, Altafaj X. Disease-associated GRIN protein
truncating variants trigger NMDA receptor loss-of-function. Hum Mol Genet. 2021
Feb 25;29(24):3859-3871. doi: 10.1093/hmg/ddaa220. PMID: 33043365.

5: Ferrer I, Andrés-Benito P, Carmona M, Assialioui A, Povedano M. TDP-43
Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS)
and Frontal Cortex in sALS/FTLD-TDP. J Neuropathol Exp Neurol. 2021 Feb
22;80(3):229-239. doi: 10.1093/jnen/nlaa162. PMID: 33421065; PMCID: PMC7899266.

6: Morató X, Garcia-Esparcia P, Argerich J, Llorens F, Zerr I, Paslawski W,
Borràs E, Sabidó E, Petäjä-Repo UE, Fernández-Dueñas V, Ferrer I, Svenningsson
P, Ciruela F. Ecto-GPR37: a potential biomarker for Parkinson's disease. Transl
Neurodegener. 2021 Feb 26;10(1):8. doi: 10.1186/s40035-021-00232-7. PMID:
33637132.

7: Hermann P, Appleby B, Brandel JP, Caughey B, Collins S, Geschwind MD, Green
A, Haïk S, Kovacs GG, Ladogana A, Llorens F, Mead S, Nishida N, Pal S, Parchi P,
Pocchiari M, Satoh K, Zanusso G, Zerr I. Biomarkers and diagnostic guidelines
for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021 Mar;20(3):235-246.
doi: 10.1016/S1474-4422(20)30477-4. Erratum in: Lancet Neurol. 2021 Feb 24;:
PMID: 33609480.

8: Madrazo Z, Osorio J, Otero A, Biondo S, Videla S; COVID-CIR Collaborative
Group. Postoperative complications and mortality following emergency digestive
surgery during the COVID-19 pandemic: A multicenter collaborative retrospective
cohort study protocol (COVID-CIR). Medicine (Baltimore). 2021 Feb
5;100(5):e24409. doi: 10.1097/MD.0000000000024409. PMID: 33592888; PMCID:
PMC7870207.

9: Hoijman E, Häkkinen HM, Tolosa-Ramon Q, Jiménez-Delgado S, Wyatt C, Miret-
Cuesta M, Irimia M, Callan-Jones A, Wieser S, Ruprecht V. Cooperative epithelial
phagocytosis enables error correction in the early embryo. Nature. 2021
Feb;590(7847):618-623. doi: 10.1038/s41586-021-03200-3. Epub 2021 Feb 10. PMID:
33568811.

10: Alay A, Cordero D, Hijazo-Pechero S, Aliagas E, Lopez-Doriga A, Marín R,
Palmero R, Llatjós R, Escobar I, Ramos R, Padrones S, Moreno V, Nadal E, Solé X.
Integrative transcriptome analysis of malignant pleural mesothelioma reveals a
clinically relevant immune-based classification. J Immunother Cancer. 2021
Feb;9(2):e001601. doi: 10.1136/jitc-2020-001601. PMID: 33632900.

11: Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S,
Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli
K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M,
Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-
Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-
Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri
C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A,
Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da
Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO,
Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM,
Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T,
Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden
C, Arévalo MA, Arguelles S, Arias E, 

12: Guinea-Izquierdo A, Giménez M, Martínez-Zalacaín I, Del Cerro I, Canal-

Noguer P, Blasco G, Gascón J, Reñé R, Rico I, Camins A, Aguilera C,

Urretavizcaya M, Ferrer I, Menchón JM, Soria V, Soriano-Mas C. Lower Locus
Coeruleus MRI intensity in patients with late-life major depression. PeerJ. 2021
Feb 16;9:e10828. doi: 10.7717/peerj.10828. PMID: 33628639; PMCID: PMC7894108.

Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP.

Ferrer I, Andrés-Benito P, Carmona M, Assialioui A, Povedano M. TDP-43 Vasculopathy in the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis (sALS) and Frontal Cortex in sALS/FTLD-TDP. J Neuropathol Exp Neurol. 2021 Jan 9:nlaa162. doi: 10.1093/jnen/nlaa162. 

Polo-Santos M, Videla-Cés S, Pérez-Hernández C, Mayoral-Rojals V, Ribera- Canudas MV, Sarría-Santamera A. An Update on Resources, Procedures and Healthcare Provision in Pain Units: A Survey of Spanish Practitioners. Int J Environ Res Public Health. 2021 Jan 8;18(2):E451. doi: 10.3390/ijerph18020451.

Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer

Macia I, Aiza G, Ramos R, Escobar I, Rivas F, Ureña A, Aso S, Rosado G, Rodriguez-Taboada P, Deniz C, Nadal E, Capella G. Molecular Nodal Restaging Based on CEACAM5, FGFR2b and PTPN11 Expression Adds No Relevant Clinical Information in Resected Non-Small Cell Lung Cancer. J Invest Surg. 2020 Dec 21:1-10. doi: 10.1080/08941939.2020.1857479.

Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment.

Andrés-Benito P, Gelpi E, Jové M, Mota-Martorell N, Obis È, Portero-Otin M, Povedano M, Pujol A, Pamplona R, Ferrer I. Lipid alterations in human frontal cortex in ALS-FTLD-TDP43 proteinopathy spectrum are partly related to peroxisome impairment. Neuropathol Appl Neurobiol. 2020 Dec 17. doi: 10.1111/nan.12681.

Betari N, Sahlholm K, Morató X, Godoy-Marín H, Jáuregui O, Teigen K, Ciruela F, Haavik J. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- In Vitro and In Vivo Investigations. Front Pharmacol. 2020 Nov 26;11:593416. doi: 10.3389/fphar.2020.593416. PMID: 33324221; PMCID: PMC7726444.

Lachén-Montes M, Mendizuri N, Ausín K, Pérez-Mediavilla A, Azkargorta M, Iloro I, Elortza F, Kondo H, Ohigashi I, Ferrer I, de la Torre R, Robledo P, Fernández-Irigoyen J, Santamaría E. Smelling the Dark Proteome: Functional Characterization of PITH Domain-Containing Protein 1 (C1orf128) in Olfactory Metabolism. J Proteome Res. 2020 Dec 4;19(12):4826-4843. doi: 10.1021/acs.jproteome.0c00452. Epub 2020 Nov 13. PMID: 33185454.

Cambra-Badii I, Francés ML, Videla S, Farré M, Montané E, Blázquez F, Baños JE. Cinemeducation in clinical pharmacology: using cinema to help students learn about pharmacovigilance and adverse drug reactions. Eur J Clin Pharmacol. 2020 Dec;76(12):1653-1658. doi: 10.1007/s00228-020-02985-y. Epub 2020 Sep 4. PMID: 32886177.

 

Mur P, García-Mulero S, Del Valle J, Magraner-Pardo L, Vidal A, Pineda M, Cinnirella G, Martín-Ramos E, Pons T, López-Doriga A, Belhadj S, Feliubadaló L, Munoz-Torres PM, Navarro M, Grau E, Darder E, Llort G, Sanz J, Ramón Y Cajal T, Balmana J, Brunet J, Moreno V, Piulats JM, Matías-Guiu X, Sanz-Pamplona R, Aligué R, Capellá G, Lázaro C, Valle L. Role of POLE and POLD1 in familial cancer. Genet Med. 2020 Dec;22(12):2089-2100. doi: 10.1038/s41436-020-0922-2. Epub 2020 Aug 14. PMID: 32792570; PMCID: PMC7708298.

Frinchi M, Verdi V, Plescia F, Ciruela F, Grillo M, Garozzo R, Condorelli DF, Di Iorio P, Caciagli F, Ciccarelli R, Belluardo N, Di Liberto V, Mudò G. Guanosine-Mediated Anxiolytic-Like Effect: Interplay with Adenosine A1 and A2A Receptors. Int J Mol Sci. 2020 Dec 5;21(23):9281. doi: 10.3390/ijms21239281. PMID: 33291390; PMCID: PMC7729560

Dissecting the non-neuronal cell contribution to Parkinson

Pons-Espinal M, Blasco-Agell L, Consiglio A. Dissecting the non-neuronal cell
contribution to Parkinson's disease pathogenesis using induced pluripotent stem
cells. Cell Mol Life Sci. 2020 Nov 18. doi: 10.1007/s00018-020-03700-x. Epub
ahead of print. PMID: 33210214.

Lactate in the Tumor Microenvironment: An Essential Molecule in Cancer Progression and Treatment

Pérez-Tomás R, Pérez-Guillén I. Lactate in the Tumor Microenvironment: An
Essential Molecule in Cancer Progression and Treatment. Cancers (Basel). 2020
Nov 3;12(11):E3244. doi: 10.3390/cancers12113244. PMID: 33153193.

The Presence of Human Herpesvirus 6 in the Brain in Health and Disease. Biomolecules.

Santpere G, Telford M, Andrés-Benito P, Navarro A, Ferrer I. The Presence of
Human Herpesvirus 6 in the Brain in Health and Disease. Biomolecules. 2020 Nov
6;10(11):E1520. doi: 10.3390/biom10111520. PMID: 33172107.

Chemokine Ligand 12 Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic Lateral Sclerosis.

Andrés-Benito P, Povedano M, Domínguez R, Marco C, Colomina MJ, López-Pérez
Ó, Santana I, Baldeiras I, Martínez-Yelámos S, Zerr I, Llorens F, Fernández-
Irigoyen J, Santamaría E, Ferrer I. Increased C-X-C Motif Chemokine Ligand 12
Levels in Cerebrospinal Fluid as a Candidate Biomarker in Sporadic Amyotrophic
Lateral Sclerosis. Int J Mol Sci. 2020 Nov 17;21(22):E8680. doi:
10.3390/ijms21228680. PMID: 33213069.

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