Biologia Vascular

teixit vascular microscópic

The Vascular Biology Lab is focused on understanding the cellular and molecular mechanisms that control the behaviour of vascular cells during angiogenesis and blood vessel remodelling in physiological and pathological conditions. We study the importance of the vascular system in the pathophysiology of neurodegenerative and retinal disorders. We aim to define how pericytes and endothelial cells communicate and interact to maintain vascular integrity and to identify key molecular players involved.

To meet our goals, we use an interdisciplinary approach that includes genetic tools in mouse, clinical validations in human samples, cell culture models, molecular biology assays, system biology approaches and high-resolution fluorescence microscopy.

Our current projects are focused on studying the role of TDP-43 in vascular stability and on modelling vascular retinal diseases by modifying pericyte biology.

  • Eloi Montañez Miralles, Profesor Agregat  IP i responsable del grup  emontanez@ub.edu

 

 

 

  • Victor Arribas Payà                Predoctoral researcher varribas@ub.edu

  • Lucia Sanchez Arcas             Predoctoral researcher  

 

  • Catalina Prats Lluís               Lab Technician      cati.prats@ub.edu

 

Active Research Projects PI Pilar Villacampa

2024-2026. Consolidación Investigadora 2023 (CNS2023-144390). Characterisation of a novel animal model of pericyte-driven retinal fibrosis (FibroRet). Quantity: 200.000€.

2022-2025. Proyectos Generación de Conocimiento MCINN (PID2021-124400OA-I00). Identifying pericyte-derived therapeutic targets for pathological neovascularisation (PeriTher). Quantity: 169.000€.

2022-2027. Contrato Ramón y Cajal MCINN (RyC2020-029929-I). Multicellular approach for the study of diabetic retinopathy and the identification of therapeutic targets. Quantity: 42.000€.

2022-2024. Ajuts per donar suport a l’activitat científica dels grups de recerca de Catalunya (SGR-Cat 2021, 2021SGR00316). Endocrinologia i metabolisme. Awarded amount: 60.000€ (10.000€ for PV).

 

Active Research Projects PI Eloi Montañez

2020-2023. Proyectos Generación de Conocimiento MCINN (PID2019-108902GB-I00). Role of TDP-43 in endothelial cells, and its significance in angiogenesis, blood vessel function and vascular homeostasis. Quantity: 121.000€.

2022-2024. Ajuts per donar suport a l’activitat científica dels grups de recerca de Catalunya (SGR-Cat 2021, 2021SGR00316). Endocrinologia i metabolisme. Awarded amount: 60.000€ (10.000€ for EM).

2023-2026. Proyectos Generación de Conocimiento MCINN (PID2022-141840OB-I00). Deciphering the role of TDP-43 in angiogenesis, vascular barrier and homeostasis of blood vessels under both physiological and pathological conditions. Quantity: 200.000€.

2024-2027. La Fundació Marató de TV3 (202327-10). Deciphering the role of TDP-43 in vascular barrier and blood vessel stability. Quantity: 120.000€.

 

ORCID Eloi Montañez: 0000-0003-4059-5056

ORCID Pilar Villacampa: 0000-0002-2860-7475

Selected Publications

  • Arribas V, Onetti Y, Ramiro-Pareta M, Villacampa P, Beck H, Alberola M, Esteve-Codina A, Merkel A, Sperandio M, Martínez-Estrada OM, Schmid B, Montanez E. Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation. JCI Insight. 2024 Feb 1;9(5):e177819.

 

 

  • Munuera I, Aragon-Navas A, Villacampa P, Gonzalez-Cela MA, Subías M, Pablo LE, Garcia-Feijoo J, Herrero-Vanrell R, Garcia-Martin E, Bravo-Osuna I, Rodrigo MJ. Chronic Glaucoma Induced in Rats by a Single Injection of Fibronectin-Loaded PLGA Microspheres: IOP-Dependent and IOP-Independent Neurodegeneration. Int J Mol Sci. 2023 Dec 19;25(1):9.

 

  • Hipke K, Pitter B, Hruscha A […] Montanez E, Schmid B. Loss of TDP-43 causes ectopic endothelial sprouting and migration defects through increased fibronectin, vcam 1 and integrin α4/β1. Front Cell Dev Biol. (2023) 11:1169962.

 

  • Onetti Y, Kälin RE, Pitter B, Hou M, Arribas V, Glass R, Montanez E. Deletion of endothelial alpha-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis. Angiogenesis. (2022) 25:155-158.

 

  • Figueiredo AM, Villacampa P, Diéguez-Hurtado R, José Lozano J, Kobialka P, Cortazar AR, Martinez-Romero A, Angulo-Urarte A, Franco CA, Claret M, Aransay AM, Adams RH, Carracedo A, Graupera M. Phosphoinositide 3-Kinase-Regulated Pericyte Maturation Governs Vascular Remodeling. Circulation. 2020 Aug 18;142(7):688-704.

 

  • Werner AC, Weckbach LT, Salvermoser M […] Montanez E. Coronin 1B controls endothelial actin dynamics at cell-cell junctions and is required 1 for endothelial network assembly. Front Cell Dev Biol. (2020) 8:708.

 

  • Altstätter J, Hess MW, Costell M, Montanez E. α-parvin is required for epidermal morphogenesis, hair follicle development and basal keratinocyte polarity. PLoS One. (2020) 15(3): e0230380.

 

 

  • Fraccaroli A, Pitter B, Taha A […] Montanez E. Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions. Circ Res. (2015) 117:29-40.

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Collaborators

Mariona Graupera (Josep Carreras Leukaemia Research Institute, Spain)

Luis Arias (Hospital Universitari de Bellvitge, Spain)

Maria Jesús Rodrigo, Elena García, Luis Pablo (Hospital Miguel Servet, Spain)

Irene Bravo, Rocio Herrero (Universidad Complutense Madrid, Spain)

Claudio Franco (Universidade Católica Portuguesa, Portugal)

Markus Sperandio, Heike Beck (Ludwig-Maximilians-University Munich, Germany)

Ofelia M Martínez-Estrada (University of Barcelona, Spain)

Bettina Schmid (German Center for Neurodegenerative Diseases, Germany)

 

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