Inmunoregulación de la respuesta innata y adaptativa. IP: Francisco Lozano Soto

Francisco Lozano Soto, MD PhD
Profesor Titular de Universidad
Teléfono: +34 932275400 ext 4217/4546
Correo-e: flozano@clinic.cat

 

Carles Serra Pagès, MD PhD
Profesor Asociado
Teléfono: +34 932275400 ext 4216/4454
Correo-e: cserra@clinic.cat

 

María Velasco de Andrés, BSc
Investigadora Postdoctoral
Teléfono: +34 932275400 ext 4546
Correo-e: mvelascodeandres@gmail.com

 

Lucía Aragón Serrano
Estudiante de Doctorado (Programa FPI)
Teléfono +34 932275400 ext 4546
Correo-e: laragons@recerca.clinic.cat

 

Laura Carrillo Serradell, BSc
Estudiante de Doctorado (Programa FPI)
Teléfono: +34 932275400 ext 4546
Correo-e: lcarriis7@alumnes.ub.edu

 

Violeta Planells Romeo
Estudiante de Doctorado (Programa FPU)
Teléfono: +34 932275400 ext. 4546
Correo-e: planellsi@recerca.clinic.cat

• Estructura i funció dels receptors limfoides i no limfoides de la superfamilia del receptor Scavenger Cysteine-Rich (SRCR)
• Interaccions host-patogen
• Control genètic de les respostes immunes als trastorns infecciosos, autoimmunitaris i neoplàsics
• Activació i desenvolupament de limfòcits

• Development and preclinical optimization of new immunomodulatory therapies in infection and cancer based on scavenger-type lymphocyte receptors

Entidad Financiadora: Ministerio de Ciencia e Investigacion (PID2022-140932OB-I00)
Investigador Principal: Dr. Francisco Lozano
Importe: 325.000 €
Fecha: 2023-2026

• Immunoreceptores del Sistema Inmunitario Innato y Adaptativo

Entidad Financiadora: Agència de Gestió d’Ajuts Universitaris i de Recerca (AGAUR), 2021/SGR/01134
Investigador Principal: Dr. Francisco Lozano
Importe: 40.000 €
Fecha: 2022-2024

• Modulación de la interacción hospedero parásito mediante el uso de péptidos sintéticos derivados de receptores scavenger

Entidad Financiadora: Comisión Sectorial de Investigación Científica (CSIC) de la Universidad de la República (Uruguay)
Investigador Principal: Gustavo Mourglia-Ettlin
Importe: URU 1.249.999 (aprox. USD 30.000)
Fecha: 01/04/2021-31/03/2023

• Receptores linfocitarios scavenger como dianas de inmunomodulación en respuesta a agresión microbiana

Entidad Financiadora: Ministerio de Ciencia e Innovación (PID2019-106658RB-I00)
Investigador Principal: Dr. Francisco Lozano
Importe: 217.800 €
Fecha: 2020-2022.

• Aproximaciones experimentales al estudio de las propiedades inmunomoduladores de receptores linfocitarios tipo scavenger en patología inmunomediada

Entidad Financiadora: Ministerio de Economía y Competitividad (SAF2016-80535-R)
Investigador Principal: Dr. Francisco Lozano
Importe: 240.000 €
Fecha: 2017-2019

• SRCR proteins as microorganism pattern recognition receptors: a wide search for interactions with pathogenic bacteria (SRecognite)”. Infect-ERA

Entidad Financiadora: Ministerio de Economía y Competitividad (PCIN-2015-070)
Investigador Principal: Dr. Francisco Lozano
Importe: 100.000 €
Fecha: 2016-2018

• CD5 y CD6 como dianas de inmunomodulación en modelos experimentales de autoinmunidad e infección

Entidad Financiadora: Ministerio de Economía y Competitividad (SAF2013-46151-R)
Investigador Principal: Dr. Francisco Lozano
Importe: 235.000 €
Fecha: 2014-2017 (Julio)

• Soluble scavenger-like lymphocyte as novel immunomodulatory agents in cancer

Entidad Financiadora: Fundació La Marató TV3 (Ref. 201319-30-31-32)
Investigador Principal: Dr. Francisco Lozano
Importe: 350.000 €
Fecha: 2014-2017 (Diciembre)

Para más información sobre las publicaciones del IP del grupo pueden visitar el siguiente enlace:
ORCID: https://orcid.org/0000-0003-1119-4368

 

Aragón-Serrano L, Carrillo-Serradell L, Planells-Romeo V, Isamat M, Velasco-de Andrés M, Lozano F. CD6 and its interacting partners: newcomers to the block of cancer immunotherapies? Int J Mol Sci 2023 Dec 15;24(24): 17510. doi: 10.3390/ ijms242417510. PMID: 38139340

Ratia C, Ballén V, Gabasa Y, Soengas RG, Velasco-de Andrés M, Iglesias MJ, Cheng Q, Lozano F, Arnér E, López-Ortiz F, Soto SM. Novel gold(III)-dithiocarbamate complex targeting bacterial thioredoxin reductase: antimicrobial activity, synergy, toxicity and mechanistic insights. Front Microbiol 2023 Jun 2:14: 1198473. doi: 10.3389/ fmicb.2023. 1198473. eCollection 2023, PMID: 37333656

Velasco-de Andrés M, Muñoz-Sánchez G, Carrillo-Serradell L, Gutiérrez-Hernández M, Català C, Isamat M, Lozano F.  Chimeric antigen receptor-based therapies beyond cancer. Eur J Immunol 2023; Jan 17; e2250184. doi: 10.1002/ eji.202250184. PMID: 36678687

Bonelli J, Velasco-de Andrés M, Isidro N, Bayó C, Chumillas S, Carrillo-Serradell L, Casadó-Llombart S, Mok C, Benítez-Ribas D, Lozano F, Rocas J, Marchán V. Novel Tumor-Targeted Self-Nanostructured and Compartmentalized Water-in-Oil-in-Water Polyurethane-Polyurea Nanocapsules for Cancer Theragnosis. Pharmaceutics 2022 Dec 24;15(1): 58. Dec 24; 15(1):58. doi: 10.3390/ pharmaceutics15010058. PMID: 36678687

Casadó-Llombart S, Ajami T, Consuegra-Fernández M, Carreras E, Aranda F, Armiger N, Alcaraz A, Mengual L, Lozano F. Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution. Prostate 2022 Oct ;82(14): 1331-1337. doi: 10.1002/ pros.24407. Epub 2022 Jun 29. PMID: 35767366

Casadó-Llombart S, Ajami T, Consuegra-Fernández M, Carreras E, Aranda F, Armiger N, Alcaraz A, Mengual L, Lozano F. Gene variation impact on prostate cancer progression: Lymphocyte modulator, activation, and cell adhesion gene variant contribution. Prostate 2022 Oct ;82(14): 1331-1337. doi: 10.1002/ pros.24407. Epub 2022 Jun 29. PMID: 35767366

Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Suarez B, Armiger N, Carreras E, Esteller M, Ricart E, Ordás I, Gisbert JP, Chaparro M, Esteve M, Márquez L, Busquets D, Iglesias E, García-Planella E, Martín-Arranz MD, Lohmann J, Ayata K, Niess JH, Panés J, Salas A, Domènech E, Lozano F. Experimental and genetic evidence for the impact of CD5 and CD6 expression and variation in inflammatory bowel disease. Front Immunol 2022 Sep 21; 13:966184. doi: 10.3389/ fimmu.2022.966184. eCollection 2022. PMID: 36211446

Bodro M, Cervera C, Linares L, Suárez B, Llopis J, Sanclemente G, Casadó-Llombart S, Fernández-Ruiz M, Fariñas MC, Cantisan S, Montejo M, Cordero E, Oriol I, Marcos MA, Lozano F*, Moreno A* and GESITRA-SEIMC-REIPI Investigators. Polygenic innate immunity score to predict the risk of cytomegalovirus infection in CMV D+/R- transplant recipients. A Prospective Multicenter cohort study. Front Immunol 2022 Aug 9;13: 897912. doi: 10.3389/ fimmu.2022.897912. eCollection 2022. PMID: 36016941

Català C, Velasco-de Andrés M, Leyton-Pereira A, Casadó-Llombart S, Sáez-Moya M, Gutiérrez-Cózar R, García-Luna J, Consuegra-Fernández M, Isamat M, Aranda F, Martínez-Florensa M, Engel P, Mourglia-Ettlin G, Lozano F. CD6 deficiency impairs early immune response to bacterial sepsis. iScience 2022 Sep 5; 25(10): 105078. doi: 10.1016/ j.isci.2022.105078. eCollection 2022. PMID: 36157587

Gartrell RD, Blake Z, Rizk EM, Perez-Lorenzo R, Weisberg S, Simoes I, Esancy C, Fu Y, Davari DR, Barker L, Finkel G, Mondal M, Minns HE, Wang SW, Fullerton BT, Lozano F, Chiuzan C, Horst B, Saenger YM. Combination immunotherapy including OncoVEXmGMCSF creates a favorable tumor immune micro environment in transgenic BRAF murine melanoma. Cancer Immunol Immunother 2022 Aug;71(8): 1837-1849.
doi: 10.1007/ s00262-021-03088-y. Epub 2022 Jan 9. PMID: 34999916

Kousathanas A, Pairo-Castineira E, Rawlik K, Stuckey A, Odhams CA, Walker S, Russell CD, Malinauskas T, Wu Y, Millar J, Shen X, Elliott KS, Griffiths F, Oosthuyzen W, Morrice K, Keating S, Wang B, Rhodes D, Klaric L, Zechner M, Parkinson N, Siddiq A, Goddard P, Donovan S, Maslove D, Nichol A, Semple MG, Zainy T, Maleady-Crowe F, Todd L, Salehi S, Knight J, Elgar G, Chan G, Arumugam P, Patch C, Rendon A, Bentley D, Kingsley C, Kosmicki JA, Horowitz JE, Baras A, Abecasis GR, Ferreira MAR, Justice A, Mirshahi T, Oetjens M, Rader DJ, Ritchie MD, Verma A, Fowler TA, Shankar-Hari M, Summers C, Hinds C, Horby P, Ling L, McAuley D, Montgomery H, Openshaw PJM, Elliott P, Walsh T, Tenesa A; GenOMICC investigators; 23andMe investigators; COVID-19 Human Genetics Initiative; Fawkes A, Murphy L, Rowan K, Ponting CP, Vitart V, Wilson JF, Yang J, Bretherick AD, Scott RH, Hendry SC, Moutsianas L, Law A, Caulfield MJ, Baillie JK. Whole-genome sequencing reveals host factors underlying critical COVID-19. Nature 2022 Jul; 607(7917):97-103. doi: 10.1038/ s41586-022-04576-6. Epub 2022 Mar 7. PMID: 35255492

Català C, Velasco-de Andrés M, Casadó-Llombart S, Leyton-Pereira A, Carrillo-Serradell L, Isamat M, Lozano F*. Innate immune response to peritoneal bacterial infection. Int Rev Cell Mol Biol 2022;371: 43-61. doi: 10.1016/ bs.ircmb.2022. 04.014. Epub 2022 Jul 12. PMID: 35965000

Fazekas B, Alagesan S, Watson L, Ng O, Conroy CM, Català C, Velascode Andres M, Negi N, Gerlach JQ, Hynes SO, Lozano F, Elliman SJ, Griffin MD. Comparison of single and repeated dosing of anti-inflammatory human umbilical cord mesenchymal stromal cells in a mouse model of polymicrobial sepsis. Stem Cell Rev Rep 2022 Apr;18(4): 1444-1460. doi: 10.1007/ s12015-021-10323-7. Epub 2022 Jan 10. PMID: 35013938

Casadó-Llombart S, Gheytasi H, Ariño S, Consuegra-Fernández M, Armiger-Borrás N, Kostov B, Ramos-Casals M, Brito-Zerón P*, Lozano F*. Gene variation at immunomodulatory and cell adhesion molecules loci impacts primary Sjögren’s syndrome. Front Med 2022 Mar 18;9:822290. doi: 10.3389/ fmed.2022. 822290. eCollection 2022. PMID: 35372412

Ratia C, Cepas V, Soengas R, Navarro Y, Velasco-de Andrés M, Iglesias MJ, Lozano F, López-Ortiz F, Soto SM. A C∧S-Cyclometallated Gold(III) Complex as a Novel Antibacterial Candidate Against Drug-Resistant Bacteria. Front Microbiol 2022 Mar 3;13:815622. doi: 10.3389/ fmicb.2022. 815622. eCollection 2022. PMID: 35308343

Pose E, Coll M, Zeng Z, Surewaard BGJ, Fuster D, Pavía J, Graupera, Muñoz É, Català C, Velasco-De Andrés M, Lozano JJ, Lozano F, Sancho-Bru P, Kubes P, Ginès P. PD-L1 is overexpressed in liver macrophages in chronic liver diseases and its blockade improves the antibacterial activity against infections. Hepatology 2021 2020 Nov 20, doi: 10.1002/ hep.31644. Online ahead of print. (*) Senior co-authorship. PMID: 33219516

Casadó-Llombart S, Velasco-de Andrés M, Català C, Leyton-Pereira A, Lozano F*, Bosch E*. Contribution of evolutionary selected immune gene polymorphism to immune-related disorders: the case of lymphocyte scavenger receptors CD5 and CD6. In J Mol Sci 2021 May 18;22(10): 5315, doi: 10.3390/ ijms22105315. (*) Senior co-authorship. PMID: 34070159

Velasco-de Andrés M, Català C, Casadó-Llombart S, Simões I, Zaragoza O, Carreras E, Lozano F. The lymphocyte scavenger receptor CD5 plays a non-redundant role in fungal infection. Cell Mol Immunol  2021 Feb;18(2):498-500, doi: 10.1038/ s41423-020-0434-7. Ep. PMID: 32332900

Velasco-de-Andrés M, Català C, Casadó-Llombart S, Martínez-Florensa M, Simões I, Mourglia-Ettlin G, Zaragoza O, Carreras E, Lozano F. The lymphocytic scavenger receptor CD5 shows therapeutic potential in mouse models of fungal infection. Antimicrob Agents Chemother 2020 Dec 16;65(1): e01103-20, doi: 10.1128/ AAC.01103-20. Print 2020 Dec 16. PMID: 33046489

Velasco-de Andrés M, Casadó-Llombart S, Català C, Leyton-Pereira A, Lozano F*, Aranda F*. Soluble CD5 and CD6: Lymphocytic class I scavenger receptors as immunotherapeutic agents. Cells 2020 Dec 3; 9(12): 2589.  doi: 10.3390/ cells9122589. (*) Senior co-authorship. PMID: 33287301

Bosch M, Sánchez-Alvarez M, Fajardo A, Kapetanovic R, Steiner B, Dutra F, Moreira L, López JA, Campo R, Marí M, Morales-Paytuví F, Tort O, Gubern A, Templin RM, Curson JEB, Martel N, Català C, Lozano F, Tebar F, Enrich C, Vázquez J, Del Pozo MA, Sweet MJ, Bozza PT, Gross SP, Parton RG, Pol A. Mammalian lipid droplets are innate immune hubs integrating cell metabolism and host defence. Science 2020 Oct 16; 370(6514): eaay8085, doi: 10.1126/ science. aay8085. PMID: 33060333

Miles S, Velasco-de-Andrés M, Lozano F*, Mourglia-Ettlin G*. Interactome analysis of CD5 and CD6 ectodomains with tegumental antigens from the helminth parasite Echinococcus granulosus sensu lato. Int J Biol Macromol 2020 Dec 1;164: 3718-3728. doi: 10.1016/ j.ijbiomac. 2020.08.219. Epub 2020 Sep 4. (*) Senior co-authorship. PMID: 32891642

Moreno-Manuel A, Jantus-Lewintre E, Simões I, Aranda F, Calabuig-Fariñas S, Carreras E, Zúñiga S, Saenger Y, Rosell R, Camps C, Lozano F*, Sirera R*. CD5 and CD6 as immunoregulatory biomarkers in Non-Small Cell Lung Cancer. Transl Lung Cancer Res 2020 Aug; 9(4): 1074-1083, doi: 10.21037/ tlcr-19-445. (*) Senior co-authorship. PMID: 32953486

Simões I, Aranda F, Casadó-Llombart S, Velasco-de Andrés M, Català C, Álvarez P, Consuegra-Fernández M, Orta-Mascaró M, Merino R, Merino J, Alberola-Ila J, González-Aseguinoloza G, Carreras E, Martinez VG, Lozano F. Multifaceted effects of soluble CD6 in experimental cancer models. J Immunother Cancer 2020 Mar ;8(1): e000172, doi: 10.1136 /jitc-2019-000172. PMID: 32217757

Ojeda R, Arias M, Gomez M, Vera M, Fontseré N, Rodas LM, Filella X, Reverter JC, Lozano F, Villamor N, Maduell F. Study of Biocompatibility of membranes in online hemodiafiltration. Blood Purif. 2020; 49(4): 400-408, doi: 10.1159/000504954. Epub 2019 Dec 19. PMID: 31865336

Martín-Antonio B, Suñe G, Najjar A, Pérez-Amill L, Antoñana-Vildosola A, Castella M, León S, Velasco-de Andrés M, Lozano F, Lozano E, Bueno C, Estanyol JM, Muñoz-Pinedo C, Robinson SN, Urbano-Ispizua A. Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor. J ImmunoTher Cancer 7(1):259, 2019, doi: 10.1186/s40425-019-0739-1. PMID: 31619273

Vasquez M, Consuegra-Fernández M, Aranda F, Jimenez A, Tenesaca S, Fernández M, Gomar C, Ardaiz N, Casares N, Lasarte JJ, Lozano F, Berraondo P. Treatment of experimental autoimmune encephalomyelitis by sustained delivery of low-dose interferon alpha. J. Immunol. 2019 Aug 1; 203(3): 696-704 doi: 10.4049 /jimmunol. 1801462. Epub 2019 Jun 17. PMID: 31209101

Carreras E, Velasco de Andrés M, Orta-Mascaró M, Simões IT, Català C, Zaragoza O, Lozano F. Discordant susceptibility of inbred C57BL/6 versus outbred CD1 mice to experimental fungal sepsis. Cell Microbiol. 2019 May;21(5): e12995. doi: 10.1111/ cmi.12995. Epub 2019 Jan 9. PMID: 30577088

Mourglia-Ettlin G, Miles S, Velasco-De-Andrés M, Armiger-Borràs N, Cucher M, Dematteis S, Lozano F. The ectodomains of the lymphocyte scavenger receptors CD5 and CD6 interact with tegumental antigens from Echinococcus granulosus sensu lato and protect mice against secondary cystic echinococcosis. PLoS Negl Trop Dis. 2018 Nov 30;12(11): e0006891. doi: 10.1371/ journal.pntd.0006891.  eCollection 2018 Nov. PMID: 30500820

Martínez-Florensa M, Català C, Velasco-de Andrés M, Cañadas O, Fraile-Ágreda V, Casadó-Llombart S, Armiger-Borràs N, Consuegra-Fernández M, Casals C, Lozano F. Conserved Bacterial-Binding Peptides of the Scavenger-Like Human Lymphocyte Receptor CD6 Protect From Mouse Experimental Sepsis. Front Immunol. 2018 Apr 12; 9:627. doi: 10.3389/ fimmu.2018.00627. eCollection 2018. PMID: 29706953

Consuegra-Fernández M, Lin F, Fox DA, Lozano F. Clinical and experimental evidence for targeting CD6 in immune-based disorders. Autoimmun Rev. 2018 May;17(5): 493-503. doi: 10.1016 /j.autrev.2017.12.004. Epub 2018 Mar 9. Review. PMID: 29526637

Simões IT, Aranda F, Carreras E, Andrés MV, Casadó-Llombart S, Martinez VG, Lozano F. Immunomodulatory effects of soluble CD5 on experimental tumor models. Oncotarget. 2017 Nov 20; 8(64): 108156-108169. doi: 10.18632/ oncotarget.22564. eCollection 2017 Dec 8. PMID: 29296231

Oncotarget. 2017 Nov 20;8(64): 108156- 108169. doi: 10.18632/oncotarget. 22564. Lozano F, Martínez-Florensa M. eCollection 2017 Dec 8. PMID: 29296231
Corrigendum: Commentary: The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain. Front Immunol. 2017 Nov 29;8:1660. doi: 10.3389/ fimmu.2017. 01660. eCollection 2017. PMID: 29234322

Consuegra-Fernández M, Julià M, Martínez-Florensa M, Aranda F, Català C, Armiger-Borràs N, Arias MT, Santiago F, Guilabert A, Esteve A, Muñoz C, Ferrándiz C, Carrascosa JM, Pedrosa E, Romaní J, Alsina M, Mascaró-Galy JM, Lozano F. Genetic and experimental evidence for the involvement of the CD6 lymphocyte receptor in psoriasis. Cell Mol Immunol. 2018 Oct;15(10): 898-906. doi: 10.1038/ cmi.2017.119. Epub 2017 Dec 11. PMID: 29225340

Retamozo S, Flores-Chavez A, Consuegra-Fernández M, Lozano F, Ramos-Casals M, Brito-Zerón P. Cytokines as therapeutic targets in primary Sjögren syndrome. Pharmacol Ther. 2018 Apr;184:81-97. doi: 10.1016/ j.pharmthera.2017. 10.019. Epub 2017 Oct 29. Review. PMID: 29092775

Martínez-Florensa M, Consuegra-Fernández M, Aranda F, Armiger-Borràs N, Di Scala M, Carrasco E, Pachón J, Vila J, González-Aseguinolaza G, Lozano F. Erratum for Martínez-Florensa et al., "Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis". Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01997-17. doi: 10.1128/ AAC. 01997-17. Print 2017 Nov. No abstract available.  PMID: 29066456

Aljutaily T, Consuegra-Fernández M, Aranda F, Lozano F, Huarte E. Gut microbiota metabolites for sweetening type I diabetes. Cell Mol Immunol. 2017 Jul 31. doi: 10.1038/ cmi.2017.65. [Epub ahead of print]. PMID: 28757611

Lombardo-Quezada J, Sanclemente G, Colmenero J, Español-Rego M, Arias MT, Ruiz P, Mauro E, Sastre L, Crespo G, Rimola A, Moreno A, Lozano F, Navasa M.  Mannose-Binding Lectin-Deficient Donors Increase the Risk of Bacterial Infection and Bacterial Infection-Related Mortality After Liver Transplantation. Am J Transplant. 2017 Jun 26. doi: 10.1111/ ajt.14408. [Epub ahead of print]. PMID: 28649744

Carrasco E, Escoda-Ferran C, Climent N, Miró-Julià C, Simões IT, Martínez-Florensa M, Sarukhan A, Carreras E, Lozano F. Human CD6 Down-Modulation following T-Cell Activation Compromises Lymphocyte Survival and Proliferative Responses. Front Immunol. 2017 Jun 30; 8:769. PMID: 28713387

Consuegra-Fernández M, Isamat M, Lozano F. Commentary: CD6 As a Potential Target for Treating Multiple Sclerosis. Front Immunol. 2017 Sep 29; 8:1217. PMID:29033937

Consuegra-Fernández M, Martínez-Florensa M, Aranda F, de Salort J, Armiger-Borràs N, Lozano T, Casares N, Lasarte JJ, Engel P, Lozano F. Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance. Front Immunol. 2017 May 30;8:594. PMID: 28611770

Bautista-Rodriguez C, Launes C, Jordan I, Andres M, Arias MT, Lozano F, Garcia-Garcia JJ, Muñoz-Almagro C. Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants. PLoS One. 2017 May 31;12(5): e0178377. PMID: 28562692

Vasquez M, Simões I, Consuegra-Fernández M, Aranda F, Lozano F, Berraondo P. Exploiting scavenger receptors in cancer immunotherapy: Lessons from CD5 and SR-B1. Eur J Immunol. 2017 Jul;47(7): 1108-1118. PMID: 28504304

Lozano F, Martínez-Florensa M. Commentary: The Scavenger Receptor SSc5D Physically Interacts with Bacteria through the SRCR-Containing N-Terminal Domain. Front Immunol. 2017 Mar 28;8:366. PMID: 28396672

Martínez-Florensa M, Consuegra-Fernández M, Aranda F, Armiger-Borràs N, Di Scala M, Carrasco E, Pachón J, Vila J, González-Aseguinolaza G, Lozano F. Protective Effects of Human and Mouse Soluble Scavenger-Like CD6 Lymphocyte Receptor in a Lethal Model of Polymicrobial Sepsis. Antimicrob Agents Chemother. 2016 Dec 27;61(1). pii: e01391-16. PMID: 27895015

Perelló M, González-Foruria I, Castillo P, Martínez-Florensa M, Lozano F, Balasch J, Carmona F. Oral Administration of Pentoxifylline Reduces Endometriosis-Like Lesions in a Nude Mouse Model. Reprod Sci. 2017 Jun;24(6): 911-918. PMID: 27738175

Orta-Mascaró M, Consuegra-Fernández M, Carreras E, Roncagalli R, Carreras-Sureda A, Alvarez P, Girard L, Simões I, Martínez-Florensa M, Aranda F, Merino R, Martínez VG, Vicente R, Merino J, Sarukhan A, Malissen M, Malissen B, Lozano F. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016 Jul 25;213(8):1387-97. PMID: 27377588

Potrony M, Carreras E, Aranda F, Zimmer L, Puig-Butille JA, Tell-Martí G, Armiger N, Sucker A, Giménez-Xavier P, Martínez-Florensa M, Carrera C, Malvehy J, Schadendorf D, Puig S, Lozano F. Inherited functional variants of the lymphocyte receptor CD5 influence melanoma survival. Int J Cancer. 2016 Sep 15;139(6):1297-302. PMID: 27169428

Delgado J, Bielig T, Bonet L, Carnero-Montoro E, Puente XS, Colomer D, Bosch E, Campo E,Lozano F. Impact of the functional CD5 polymorphism A471V on the response of chronic lymphocytic leukaemia to conventional chemotherapy regimens. Br J Haematol. 2017 Apr;177(1):147-150. PMID: 26991857

Mier-Aguilar CA, Vega-Baray B, Burgueño-Bucio E, Lozano F, García-Zepeda EA, Raman C, Soldevila G. Functional requirement of tyrosine residue 429 within CD5 cytoplasmic domain for regulation of T cell activation and survival. Biochem Biophys Res Commun. 2015 Oct 23;466(3):381-7. PMID: 26363459

Consuegra-Fernández M, Aranda F, Simões I, Orta M, Sarukhan A, Lozano F. CD5 as a Target for Immune-Based Therapies. Crit Rev Immunol. 2015;35(2):85-115. PMID: 26351145

Aibar J, Martínez-Florensa M, Castro P, Carrasco E, Escoda-Ferran C, Fernández S, Butjosa M, Hernández C, Rinaudo M, Lozano F, Nicolás JM. Pattern of soluble CD5 and CD6 lymphocyte receptors in critically ill patients with septic syndromes. J Crit Care. 2015 Oct;30(5): 914-9. PMID: 26031813

Miro JM, Manzardo C, Ferrer E, Loncà M, Guardo AC, Podzamczer D, Domingo P, Curran A, Clotet B, Cruceta A, Lozano F, Pérez I, Plana M, Gatell JM; Advanz-3 Study Group. Immune Reconstitution in Severely Immunosuppressed Antiretroviral-Naive HIV-1-Infected Patients Starting Efavirenz, Lopinavir-Ritonavir, or Atazanavir-Ritonavir Plus Tenofovir/Emtricitabine: Final 48-Week Results (The Advanz-3 Trial). J Acquir Immune Defic Syndr. 2015 Jun 1;69(2):206-15. PMID: 25831464

Sarukhan A, Martinez-Florensa M, Escoda-Ferran C, Carrasco E, Carreras E, Lozano F. Pattern Recognition by CD6: A Scavenger-Like Lymphocyte Receptor. Curr Drug Targets. 2016;17(6): 640-50. PMID: 25777272

Romaní J, Julià M, Lozano F, Muñoz-Santos C, Guilabert A, Carrascosa JM, Rigla M, Luelmo J. Toll-like receptor 9 promoter polymorphism as a predictive factor of narrow-band UVB phototherapy response in patients with psoriasis. Photodermatol Photoimmunol Photomed. 2015 Mar;31(2): 98-103. PMID: 25561051

Cenit MC, Martínez-Florensa M, Consuegra M, Bonet L, Carnero-Montoro E, Armiger N, Caballero-Baños M, Arias MT, Benitez D, Ortego-Centeno N, de Ramón E, Sabio JM, García-Hernández FJ, Tolosa C, Suárez A, González-Gay MA, Bosch E, Martín J, Lozano F. Analysis of ancestral and functionally relevant CD5 variants in systemic lupus erythematosus patients. PLoS One. 2014 Nov 17;9(11):e113090. PMID: 25402503

Soto-Cárdenas MJ, Gandía M, Brito-Zerón P, Arias MT, Armiger N, Bové A, Bosch X, Retamozo S, Akasbi M, Pérez-De-Lis M, Gueitasi H, Kostov B, Pérez-Alvarez R, Siso-Almirall A, Lozano F, Ramos-Casals M. Etiopathogenic role of surfactant protein d in the clinical and immunological expression of primary Sjögren syndrome. J Rheumatol. 2015 Jan;42(1):111-8. PMID: 25362659

Sanclemente G, Moreno A, Navasa M, Lozano F, Cervera C. Genetic variants of innate immune receptors and infections after liver transplantation. World J Gastroenterol. 2014 Aug 28;20(32):11116-30. PMID: 25170199

Escoda-Ferran C, Carrasco E, Caballero-Baños M, Miró-Julià C, Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Liu FT, Lozano F. Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014 Aug 25;588(17):2805-13. PMID: 24945728

Gracia M, Sisó C, Martínez-Zamora MÀ, Sarmiento L, Lozano F, Arias MT, Beltrán J, Balasch J, Carmona F. Immune and stress mediators in response to bilateral adnexectomy: comparison of single-port access and conventional laparoscopy in a porcine model. J Minim Invasive Gynecol. 2014 Sep-Oct;21(5):837-43. PMID: 24681233

Miró-Julià C, Escoda-Ferran C, Carrasco E, Moeller JB, Vadekaer DF, Gao X, Paragas N, Oliver J, Holmskov U, Al-Awqati Q, Lozano F. Expression of the innate defense receptor S5D-SRCRB in the urogenital tract. Tissue Antigens. 2014 Apr;83(4):273-85. PMID: 24641504

 Muñoz-Almagro C, Bautista C, Arias MT, Boixeda R, Del Amo E, Borrás C, Armiger N, Garcia L, Sauca G, Selva L, de Sevilla MF, Ciruela P, Yebenes JC, Pallares R, Lozano F. High prevalence of genetically-determined mannose binding lectin deficiency in young children with invasive pneumococcal disease. Clin Microbiol Infect. 2014 Oct;20(10):O745-52. PMID: 24602163

Martinez VG, Escoda-Ferran C, Tadeu Simões I, Arai S, Orta Mascaró M, Carreras E, Martínez-Florensa M, Yelamos J, Miyazaki T, Lozano F. The macrophage soluble receptor AIM/Api6/CD5L displays a broad pathogen recognition spectrum and is involved in early response to microbial aggression. Cell Mol Immunol. 2014 Jul;11(4): 343-54. PMID: 24583716

Fenutría R, Martinez VG, Simões I, Postigo J, Gil V, Martínez-Florensa M, Sintes J, Naves R, Cashman KS, Alberola-Ila J, Ramos-Casals M, Soldevila G, Raman C, Merino J, Merino R, Engel P,Lozano F. Transgenic expression of soluble human CD5 enhances experimentally-induced autoimmune and anti-tumoral immune responses. PLoS One. 2014 Jan 15;9(1):e84895. PMID: 24454761

Martínez-Florensa M, Consuegra-Fernández M, Martínez VG, Cañadas O, Armiger-Borràs N, Bonet-Roselló L, Farrán A, Vila J, Casals C, Lozano F. Targeting of key pathogenic factors from gram-positive bacteria by the soluble ectodomain of the scavenger-like lymphocyte receptor CD6. J Infect Dis. 2014 Apr 1;209(7):1077-86. PMID: 24265437

Julià M, Guilabert A, Lozano F, Suarez-Casasús B, Moreno N, Carrascosa JM, Ferrándiz C, Pedrosa E, Alsina-Gibert M, Mascaró JM Jr. The role of Fcγ receptor polymorphisms in the response to anti–tumor necrosis factor therapy in psoriasis A pharmacogenetic study. JAMA Dermatol. 2013 Sep;149(9): 1033-9. PMID: 24048425

Bonet L, Farnós M, Martínez-Florensa M, Martínez VG, Lozano F. Identification of functionally relevant phoshorylatable serine clusters in the cytoplasmic region of the human CD6 lymphocyte surface receptor. FEBS Lett. 2013 Jul 11;587(14):2205-13. PMID: 23711376

Roa NS, Ordoñez-Rueda D, Chávez-Rios JR, Raman C, García-Zepeda EA, Lozano F, Soldevila G. The carboxy-terminal region of CD5 is required for c-CBL mediated TCR signaling downmodulation in thymocytes. Biochem Biophys Res Commun. 2013 Mar 1;432(1):52-9. PMID: 23376399

Carmona F, Chapron C, Martínez-Zamora MÁ, Santulli P, Rabanal A, Martínez-Florensa M, Lozano F, Balasch J. Ovarian endometrioma but not deep infiltrating endometriosis is associated with increased serum levels of interleukin-8 and interleukin-6. J Reprod Immunol. 2012 Sep;95(1-2):80-6. PMID: 22819248

Ramírez J, Fernández-Sueiro JL, López-Mejías R, Montilla C, Arias M, Moll C, Alsina M, Sanmarti R,Lozano F, Cañete JD. FCGR2A/CD32A and FCGR3A/CD16A variants and EULAR response to tumor necrosis factor-α blockers in psoriatic arthritis: a longitudinal study with 6 months of followup. J Rheumatol. 2012 May;39(5):1035-41. PMID: 22467926

Sala-Valdés M, Gordón-Alonso M, Tejera E, Ibáñez A, Cabrero JR, Ursa A, Mittelbrunn M, Lozano F, Sánchez-Madrid F, Yáñez-Mó M. Association of syntenin-1 with M-RIP polarizes Rac-1 activation during chemotaxis and immune interactions. J Cell Sci. 2012 Mar 1;125(Pt 5):1235-46. PMID: 22349701

Carnero-Montoro E, Bonet L, Engelken J, Bielig T, Martínez-Florensa M, Lozano F, Evolutionary and functional evidence for positive selection at the human CD5 immune receptor gene. Bosch E. Mol Biol Evol. 2012 Feb;29(2):811-23. PMID: 21998275

• Ofertas de la Universidad de Barcelona:

Feina UB

• Ofertas del grupo de investigación:

Por el momento, no hay ofertas de trabajo de este grupo de investigación