Biochemistry and Molecular Biology
The unit of Biochemistry and Molecular Biology do teaching in the degrees of Medicine, Biomedical Engineering, Nursing-Clinic and Biomedical Sciences. The subjects of Basic Biochemistry, Molecular Biology, Biochemistry of Systems at the Degree of Medicine, Chemistry and Biochemistry at the degree of Biomedical Engineering, Biochemistry at the Nursing-Clinical Degree and Cell Biology of Pathology an Clinical and Analytical Biochemistry at the Biomedical Sciences degree. The unit also participates in University of Barcelona coordinated and interuniversity master's degrees (Neurosciences, Translational Medicine, Advanced Immunology ...).
Regarding research the unit has different groups with interests in the fields of neuroscience (Neurochemistry, Neuroinflammation, Molecular mechanisms in neurological/neurodegenerative diseases and identification of novel therapeutic targets), Immunology and Hepatic Pathology (Translational Research in New Strategies for Diagnosis and Treatment of Hepatic Disease).
| Auge Fradera, Josep Maria | Assistant medical professor 3P | jmauge@clinic.cat |
| Bedini Chesa, Josep Lluis | Assistant medical professor | jlbedini@clinic.cat |
| Cadefau Surroca, Joan Aureli | Assistant professor 3P | jcadefau@ub.edu |
| De Sousa Valente, Juan Tony | Assistant professor 3P | valentedesousa@ub.edu |
| Jiménez Povedano, Wladimiro | Full professor | wjimenez@ub.edu |
| López Galera, Rosa Maria | Assistant medical professor 1P | rmlopez@clinic.cat |
| Malagelada Grau, Cristina | Associate professor | cristina.malagelada@ub.edu |
| Martí Puig, Eulàlia (Head Unit, ph. 934020586) | Associate professor | eulalia.marti@ub.edu |
| Martín Andorrà, Margarita | Associate professor | martin_andorra@ub.edu |
| Melgar Lesmes, Pedro | Ramon y Cajal researcher | pmelgar@ub.edu |
| Mira Vallet, Aurea | Assistant medical professor 1P | AMIRA@clinic.cat |
| Morales Ruiz, Manuel | Assistant medical professor 3P | morales@clinic.cat |
| Ollé Boix, Laia | Assistant professor 3P | lolle@clinic.cat |
| Peluffo Zavala, Hugo Ernesto | Lecturer professor | hugo.peluffo@ub.edu |
| Pugliese, Marco | Assistant professor 3P | marcopugliese@ub.edu |
| Rodríguez Allue, Manuel José | Associate professor | marodriguez@ub.edu |
| Saura Martí, Josep | Associate professor | josepsaura@ub.edu |
Nous mecanismes moleculars i noves estratègies terapèutiques per a la conservació de la funció hepàtica en la malaltia del Fetge i la lesió hepàtica aguda
By: Bernat Cordoba Jover
Qualification: Unanimously excellent
Director: Manuel Morales Ruiz
Facultat de Medicina i Ciencies de la Salut
Universitat de Barcelona
29-01-2024
DHX15: A master regulator of liver physiology endothelial cell function and cancer
By: Irene Portóles Plaza
Qualification: Unanimously excellent
Director: Manuel Morales Ruiz
Facultat de Medicina i Ciencies de la Salut
Universitat de Barcelona
16-12-2022
Novel nanoscale therapeutic approaches to treat liver diseases
By: Meritxell Perramón Corominas
Director/s: Wladimiro Jiménez Povedano and Pedro Melgar Lesmes
Facultat de Medicina i Ciencies de la Salut
Universitat de Barcelona
2022
Role of RTP801 in synaptic transmission and neuroinflammation in neurodegenerative diseases
By: Letícia Pérez-Sisqués
Director/s: Cristina Malagelada Grau
Facultat de Medicina i Ciències de la Salut
Universitat de Barcelona
2021
Nuevas estrategias Terapeúticas contra la enfermedad del hígado graso no alcohólico y la fibrosis hepática experimental: Nanoparticulas de óxido de cerio y bloqueo de PTTG1 mediante ARNip
By: Sílvia Carvajal Restoy
Director/s: Wladimiro Jiménez Povedano and Guillermo Fernández Varo
Doctorate in Translational Medicine
Universitat de Barcelona
2020
Envolvimento do inflamassoma nlrp3 e do imunorreceptor cd300f no transtorno depressivo maior.
By: Fernanda Neutzling Kaufmann
Director/s: Hugo Peluffo and Manuella Kaster
Facultat de Medicina
Universidad Federal de Santa Catarina
2019
New insights in mast cell function triggered by FcεRI, KIT and MRGPRX2 receptors
By: Arnau Navinés Ferrer
Director/s: Margarita Martín Andorrà
Universitat de Barcelona
11/2019
Brain Immune Response as therapeutic target ni the treatment of Parkinson’s disease
By: Neus Rabaneda Lombarte
Directors: Josep Saura Martí (co-directed by Carme Solà Subirana, CSIC)
Universitat de Barcelona
07/2019
Caracterización de la función del receptor CD300f en el mantenimiento de la homeostasis del SNC y su papel durante la neuroinflamación post-traumática
By: Luciana Negro
Director/s: Hugo Peluffo and Joan Sayós
Facultat de Medicina
PEDECIBA-Universidad de la República
2018
Study of the mTOR pathway in neurodegenerative diseases: from synapses to genes
By: Núria Martín Flores
Director/s: Cristina Malagelada Grau
Facultat de Medicina i Ciències de la Salut
Universitat de Barcelona
2018
A comprehensive multiomics approach towards understanding obsessive-compulsive disorder
By: Laura Domenech Salgado
Director/s: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra (2018)
Prenatal and Postnatal exposure to tobacco smoking and molecular signatures in children
By: Marta Vives Usano
Director/s: Eulàlia Martí Puig and Mariona Bustamante
Center for Genomic Regulation
Universitat Pompeu Fabra
2018
Evaluation of noncoding RNAs in Parkinson’s disease Center
By: Joan Pallares Albanell
Director/s: Eulàlia Martí Puig
Center for Genomic Regulation
Universitat Pompeu Fabra
2017
Cerca i identificació de nous biomarcadors de fibrosi hepàtica per mitjà de tècniques proteòmiques
By: Santiago Marfà Bruix
Director/s: Wladimiro Jimenez Povedano
Universitat de Barcelona
02/2017
Deleció condicional de C/EBPβ en cél·lules de la micròglia. Nova eina per a l’estudi i la modulació de l’activació glial en models de neurodegeneració
By: Marta Pulido Salgado
Director/s: Josep Saura and Carme Solà
Universitat de Barcelona
2016
Nuevos tratamientos contra la hipertensión portal en la cirrosis hepàtica experimental en la cirrosis experimental: 1/ Nanoparticulas de oxido de cerio y 2/ Agonismo parcial del receptor V1a de la vasopresina
By: Denise Oró Bozzini
Director/s: Wladimiro Jimenez Povedano
Universitat de Barcelona
10/2016
La proteïna adaptadora 3BP2 com a regulador de l'activitat cel·lular a través dels receptors de membrana Fcepsilon RI i KIT
By: Erola Ainsua Enrich
Director/s: Margarita Martín Andorrà
Note: Excellent
Universitat de Barcelona
2014
Activació dels canals KATP com estratègia neuroprotectora pel tractament de malalties autoimmunes desmielinitzants
By: Noemí Virgili Treserres
Director/s: Marco Pugliese and Juan F. Espinosa Parrilla
Note: Excellent Cum Laude
Universitat de Barcelona
26.06.2014
Vps13a distribution in the brain of a Huntington’s disease mouse model
By: Maria Carreras Caballé
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2021)
Via NF-kB com a diana terapèutica en els dèficits cognitius de la Malaltia de Huntington associats a astrocitosi reactiva
By: Maria Oliveró Viña
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2021)
Localización tisular y distribución neuronal de la coreína en el cerebro de ratón
By: Nerea Chaparro Cabanillas
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2020)
Targeting microglial TREM2 as an Alzheimer’s disease therapy
By: Júlia Ollé Grau
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (2020)
New targets to control KIT-dependent cell signals
By: Óscar Laguía Candelaria
Director: Margarita Martín Andorrà
Universitat de Barcelona (2019)
Glial activation and its mechanism of control in Parkinson's disease
By: Neus Rabaneda Lombarte
Director: Josep Saura Martí
Bachelor's: Medicina, Universitat de Barcelona (2019)
Molecular basis of Huntington's Disease: Susceptibility of Medium Spiny Neurons
By: Anna Pelach Pueyo
Director: Manuel J Rodríguez Allué
Facultat de Farmàcia, Universitat de Barcelona (2019)
MRGPRX2: a new explanation for anaphylactoid reactions to perioperative drugs
By: Sergio Aguilar López
Director: Margarita Martín Andorrà
Universitat de Barcelona (2018)
Experimental Neurotoxic and genetic models of Parkinson’s
By: Josep Garré Cristau
Director: Josep Saura Martí
Bachelor's: Medicina, Universitat de Barcelona (2018)
Estudi de la resposta glial induïda per micropartícules de sílice nanoporoses (II)
By: Paula Carreras Domínguez
Director: Josep Saura Martí
Bachelor's: Biotecnologia, Universitat de Barcelona (2018)
Caracterització de cultius de cèl·lules microglia-like a partir de monòcits humans adults
By: Clara Alba Rey
Director: Josep Saura Martí
Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2018)
Natural targets to combat weakness in neuromuscular disease
By: Anna Sanchez Àvila
Director: Josep Saura Martí
Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2018)
T cells: the key to recovery after stroke? A critical Review
By: Míriam Mayor Echave-Sustaeta
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2018)
La esclerosis lateral amiotrófica y sus mecanismos patológicos de agregación proteica
By: Miguel Pérez Nieto
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2018)
Dysregulation of Gene expression deregulation in heart and skeletal muscle of Huntington’s disease induced mice
By: Clara Farrés Álvarez
Director: Eulàlia Martí Puig
Bachelor's de Biologia Humana, Universitat Pompeu Fabra (2018)
New mirnas involved ingastrointestinal stromal tumor cells viability
By: Cindy Gabriela Mancía
Director: Margarita Martín Andorrà
Universitat de Barcelona (2017)
Estudi de la resposta glial induïda per micropartícules de sílice nanoporoses
By: Júlia Sala Jarque
Director: Josep Saura Martí
Bachelor's: Biotecnologia, Universitat de Barcelona (2017)
Mechanisms of neuroinflammation in amyotrophic lateral sclerosis (ALS)
By: Nil Albiol Zamora
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2017)
New molecules involved in the signaling of oncogenic receptors KIT and pdgfrα
By: Cristina Belda Marín
Director: Margarita Martín Andorrà
Universitat de Barcelona (2016)
Role of ATP-dependent potassium channels in reactive microglia in amyotrophic lateral sclerosis (ALS)
By: Carolina Roqueta Bachelor's
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2016)
Unravelling non-coding RNA mechanisms in neurodegenerative conditions
By: Clara Domingo Sabugo
Director: Eulàlia Martí Puig
Bachelor's: Ciències Biomèdiques, Universitat de Barcelona (2016)
Novel neuroprotective therapies for multiple sclerosis: an updated review
By: Albert Cortés Bullich
Director: Marco Pugliese
Qualification: 8,9
Universitat de Barcelona (2015-2016)
OMALIZUMAB: Where do we come from? Where are we going?
By: Ignacio Molina Molina
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)
Obtaining a 3BP2 proline rich domain deleted mutant. Implications in ligands binding.
By: Oriol Careta Borrás
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)
ATP-sensitive potassium channel (KATP) and L-type voltage-gated calcium channel (L-VGCC) coupling in BV-2 microglial cells
By: Carla Barona
Director: Manuel J Rodríguez Allué
Facultat de Medicina, Universitat de Barcelona (2014)
3BP2 adaptor molecule role in Kit oncogènic downregulation in gastrointestinal stromal tumor (GIST) cells. Implications in therapy
By: Ignacio Bon Romero
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)
La interacció entre Myo1f i 3BP2 en Mastòcits Humans.
By: Cristina Luque Bailén
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)
Evaluation of the hepatic metabolic effects of ceria and gold nanozymes in an experimental model of metabolic dysfunction-associated steatohepatitis
By: Xingyu Yang (ongoing)
Directors: Gregori Casals Mercadal and Guillermo Fernández Varo
Masteren Nanofarmacèutica i nanomedicina
Facultat de Medicina i Ciències de la Salut (2024)
Matrix-embedded endothelial cells: a novel immunomodulatory engineered therapeutic strategy for liver diseases
By: Maria Blanca Simón Codina
Director: Pedro Melgar Lesmes
Qualification: 9.9 (Honors)
Master in Biomedicine
Facultat de Medicina i Ciències de la Salut (07/2023)
PPAR-γ Agonist GW1929 Targeted to Macrophages with Dendrimer–Graphene Nanostars Reduces Liver Fibrosis and Inflammation
By: Montserrat Barber González
Director: Pedro Melgar Lesmes
Qualification: 9.4
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (07/2023)
In vitro and in vivo deciphering of macrophage heterogeneity and zonation phenomena in hepatocellular carcinoma
By: Arnau Masó Carretero
Director: Pedro Melgar Lesmes
Qualification: 9.5 (Honors)
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (09/2022)
Effect of mesoporous silica-coated inorganic nanoparticles in an experimental model of steatohepatitis
By: Elena Lecue Costas
Directors: Gregori Casals Mercadal, Guillermo Fernández Varo and Manuel Morales Ruiz
Master: Nanopharmaceutics and Nanomedicine
Facultad de Física i Química de la UB (15/07/2022,12h)
Gene expression profile and phenotype characterization of macrophages transformed by liver cancer cells: an approach for modelling tumor-associated macrophages
By: Alejandro Martínez Navarro
Director: Pedro Melgar Lesmes
Qualification: 9.0
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (07/2021)
Approaching the role of chorein in neurons and establishing a cellular model of chorea-acanthocytosis disease
By: Nerea Chaparro Cabanillas
Director: Manuel J Rodríguez Allué
Facultat de Medicina i Ciències de la Salut (2021)
Cerium Oxide Nanoparticles as a Potential Experimental Treatment for Bleomicyn-Induced Acute Respiratory Distress Syndrome in Rats
By: Alejandro Vidal.
Qualification: 8,40/10
Director: Wladimiro Jiménez
Facultat de Medicina i Ciències de la Salut (2020-2021)
Modulation of macrophages using matrix-embedded endothelial cells to reduce liver fibrosis
By: Laura Piñeiro Alonso
Director: Pedro Melgar Lesmes
Qualification: 8,2
Master in Advanced Immunology
Facultat de Medicina i Ciències de la Salut (09/2020)
Characterization of human microglia-like cells and studies on C/EBP transcription factors
By: Elia Micoli
Directors: Josep Saura and Enrico Tongiorgi
Master in Neurosciences, University of Trieste (2020)
LNA-CTG administration as a therapeutic approach in Huntington’s disease
By: Maria Solaguren Beascoa
Director: Eulàlia Martí Puig
Universitat de Barcelona (2019)
KARS, a new target in anaphylaxis
By: Pau Ribó Molina
Director: Margarita Martín Andorrà
Universitat de Barcelona (2019)
By: Andrea Llaves López
Director: Josep Saura Martí
Master of Translational Medicine. Universidad de Barcelona (2019)
Potential effect of Cerium Oxide Nanoparticles in an experimental model of NAFLD
By: Shayan Shahbazi Dastjerdeh. Qualification: 8,30/10
Directors: Guillermo Fernández Varo, Gregori Casals and Wladimiro Jiménez
IX Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2018-2019)
MiR-1246 and miR-5100 target MITF and decrease GIST cell viability
By: Cindy Gabriela Mancía
Director: Margarita Martín Andorrà
Universitat de Barcelona (2018)
Targeted matrix metalloproteinase 9 overexpression in macrophages promotes a phenotype switch boosting fibrosis resolution
By: Aureli Luquero Gómez
Directors: Pedro Melgar Lesmes and Wladimiro Jiménez
Qualificació: 8,7 (Matrícula d'honor)
Master of Advanced Immunology, Univ. de Barcelona/Univ.Autònoma de Barcelona (2018)
Distribución de la coreína en el cerebro de ratón
By: Álvaro Llorens Rastrollo
Director: Manuel J Rodríguez Allué
Facultat de Biologia, Universitat de Barcelona (2018)
Selection and validation of novel drugs based on system biology target discovery to ameliorate symptoms in Huntington's disease
By: Esther García García
Director: Manuel J Rodríguez Allué
Facultat de Farmàcia, Universitat de Barcelona (2018)
By: Anna Guisado Corcoll
Director: Eulàlia Martí Puig (co-supervisad amb Dr. Esther Perez-Navarro)
Master in Neurosciences, Univeristat de Barcelona (2018)
New tools for single-cell diagnostic of liver càncer
By: Adriana Mora Barrabés
Directors: Pedro Melgar Lesmes and Wladimiro Jiménez
Qualificació: 7,2
VIII Master of Translational Medicine
MSc-CELLEX, Universitat de Barcelona (2018)
Stimulation of functional liver regeneration in cirrhotic livers through intrahepatic vascular normalization and modulation of Akt targets
By: Raúl del Rey Vergara
Director: Manuel Morales Ruiz
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2018)
Analysis of molecules involved in KIT regulation in a new cellular model for mastocytosis
By: Alexis Eduardo Pérez Paredes
Director: Margarita Martín Andorrà
Universitat de Barcelona (2017)
Microglia-like cells as a neuroinflammation model for Parkinson’s Disease
By: Gerard Aguilar Pérez
Director: Josep Saura Martí
Master of Translational Medicine, Universitat de Barcelona (2017)
Long non-coding RNA in Parkinson’s Disease
By: Manisha Arumalla
Director: Eulàlia Martí Puig
Master in Genetics and Genomics, Universitat de Barcelona (2017)
RNA toxicity in Huntington’s disease
By: Cristina Navarrete Hernandez
Director: Eulàlia Martí Puig
Master in Genetics and Genomics, Universitat de Barcelona (2017)
Evaluation of antioxidant and anti-steatotic effects of cerium oxide nanoparticles as promising therapeutic agent in the non-alcoholic fatty liver
By: Marina Parra Robert
Directors: Gregori Casals and Wladimiro Jiménez
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2017)
Effect of cerium oxide nanoparticles on oxidative stress and cellular oxysterols production
By: Núria Massana Martinell
Director: Gregori Casals and Wladimiro Jiménez
Master in Laboratory of Clinical Analysis, Universitat Pompeu Fabra (2017)
Functional Characterization of DDX15 gene deficiency
By: Irene Portolés Plaza
Director: Manuel Morales Ruiz
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2017)
Human microglia-like cells as a neuroinflammation model for Parkinson’s Disease. Characterization of alpha-synuclein effects in human microglia-like cells
By: Carla Belmonte Mateos
Director: Josep Saura Martí
Master of Neurosciences. Universitat de Barcelona (2016)
Effects of nanoporous silica particles on glial cells
By: Elisa García Lara
Director: Josep Saura Martí
Master of Translational Medicine. Universitat de Barcelona (2016)
Analysis of casein kinase II expression in hepatic stellate cells and its possible role in hepatic inflammation and fibrosis
By: Meritxell Perramón Corominas
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
VIII Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2016)
Study of the role of the adaptor protein 3BP2 in k562 cells. A chronic myelogenous leukaemia cellular model
By: Ignacio Bon Romero
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)
Estudio in vitro del Omalizumab (anti-IgE) en Urticaria Crónica
By: Elizabeth Proaño
Director: Margarita Martín Andorrà
Universitat de Barcelona (2015)
Preparation of microglia-like cell cultures from human peripheral blood monocytes. Preliminary study of C/EBPβ and C/EBPδ expression
By: Anaïs Marsal Cots
Director: Josep Saura Martí
Master of Neurosciences. Universitat de Barcelona (2015)
Analysis of gene expression perturbations in Huntington’s disease models after administration of LNA-oligonucleotides complementary to the CAG repeat.
By: Zeus Aranda Remon
Director: Eulàlia Martí Puig
Master in Biomedical Research, Universitat Pompeu Fabra (2015)
3BP2, KIT and Myo1f in Mast cell migration and activation
By: Arnau Navinés Ferrer
Director: Margarita Martín Andorrà
Universitat de Barcelona (2014)
Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition
By: Blai Morales Romero
Director: Manuel Morales Ruiz
IV Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2014)
Expression and regulation of AVPR2 and AQP-2 genes in Hepatic Stellate Cells (HSCs)
By: Berta Serra Navarro
Directors: Guillermo Fernández Varo and Wladimiro Jiménez
IV Master of Translational Medicine, MSc-CELLEX, Universitat de Barcelona (2014)
Gene expression deregulation induced by locked nucleic acids targeting small CAG-repeated RNAs (LNA-asCAG) in R6/2 mouse model for huntington’s disease
By: Gartze Mentxaca Miranda
Director: Eulàlia Martí Puig
Master in Biomedical Research, Universitat Pompeu Fabra (2014)
