Published a new article from the group of Prof. Alberto Muñoz describing the role of vitamin D in the differentiation of the human colon epithelium
![Nuevo artículo en el que participa el doctor Alberto Muñoz](https://www.ub.edu/nurcamein/wp-content/uploads/2024/05/nuevo-articulo-doctor-munoz.webp)
Prof. Alberto Muñoz’s group, in collaboration with researchers from the National Cancer Research Center (CNIO), the University of Cantabria and the La Paz University Hospital, has published a new article in the journal “Cell Death & Disease” titled: Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids.
For the first time, the effect of vitamin D on the differentiation capacity of colonic epithelial cells towards their two main lineages: enterocytic and mucosecretory cells is defined. This work has been carried out on organoids, which are three-dimensional structures generated from stem cells of the colonic epithelium obtained from biopsies of patients with colon cancer, being, therefore, a cellular model that accurately reproduces the characteristics of the tissue. Through transcriptomic and ultrastructural analyses, the authors demonstrate that vitamin D inhibits differentiation regulated by the Notch and BMP pathways in colonic epithelial cells.
You can read the full article by accessing the following link.