Conformational Diseases Group

Discovery of novel multifunctional ligands targeting GABA transporters, butyrylcholinesterase, β-secretase, and amyloid β aggregation as potential treatment of Alzheimer’s disease. Zaręba P.; Łątka K.; Mazur G.; Gryzło B.; Pasieka A.; Godyń J.; Panek D.; Skrzypczak-Wiercioch A.; Höfner G.C.; Latacz G.; Maj M.; Espargaró A.; Sabaté R.; Jóźwiak K.; Wanner K.T.; Sałat K.; Malawska B.; Kulig K.; Bajda M. 2023, European Journal of Medicinal Chemistry, 261, 115832. Doi: 10.1016/j.ejmech.2023.115832

Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer’s disease. Tonelli M.; Catto M.; Sabaté R.; Francesconi V.; Laurini E.; Pricl S.; Pisani L.; Miniero D.V.; Liuzzi G.M.; Gatta E.; Relini A.; Gavín R.; Del Rio J.A.; Sparatore F.; Carotti A. 2023 European Journal of Medicinal Chemistry, 250, 115169. Doi: 10.1016/j.ejmech.2023.115169

Coumarin derivatives against amyloid-beta 40 – 42 peptide and tau protein. Kowalczyk J., Skalicka-Wozniak K., Budzynska B., El Sayed N., Espargaró A., Sabate R. Current Issues in Pharmacy and Medical Sciences. 35, 2, 67, 2022

Design, Synthesis, and In Vitro, In Silico and In Cellulo Evaluation of New Pyrimidine and Pyridine Amide and Carbamate Derivatives as Multi-Functional Cholinesterase Inhibitors. Bortolami M., Pandolfi F., Tudino V., Messore A., Madia V.N., De Vita D., Di Santo R., Costi R., Romeo I., Alcaro S., Colone M., Stringaro A., Espargaró A., Sabatè R., Scipione L. Pharmaceuticals, 15, 6, 673, 2022

Characterisation of the enzymes involved in the diol synthase metabolic pathway in Pseudomonas aeruginosa. Shoja-Chaghervand S., Castells M., Rabanal F., Cajal Y., Manresa A., Estupiñán M., Busquets M. Process Biochemistry, 120, 301, 312, 2022

Dual Effect of Prussian Blue Nanoparticles on Aβ40 Aggregation: β-Sheet Fibril Reduction and Copper Dyshomeostasis Regulation. Kowalczyk J., Grapsi E., Espargaró A., Caballero A.B., Juárez-Jiménez J., Busquets M.A., Gamez P., Sabate R., Estelrich J. Biomacromolecules. 2021, 22, 2

Azobioisosteres of Curcumin with Pronounced Activity against Amyloid Aggregation, Intracellular Oxidative Stress, and Neuroinflammation. Hofmann J., Ginex T., Espargaró A., Scheiner M., Gunesch S., Aragó M., Stigloher C., Sabaté R., Luque F.J., Decker M. Chemistry – A European Journal. 2021, 27, 19

Air Curtains Equipped With Hydroalcoholic Aerosol Sprayers for Massive COVID-19 Disinfection. Raventós J., Sabate R. Frontiers in Public Health. 2021, 8, 582782

On the Binding of Congo Red to Amyloid Fibrils. Espargaró A., Llabrés S., Saupe S.J., Curutchet C., Luque F.J., Sabaté R. Angewandte Chemie – International Edition. 2020, 59(21)

1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer’s disease. Wichur T., Więckowska A., Więckowski K., Godyń J., Jończyk J., Valdivieso ÁD.R., Panek D., Pasieka A., Sabaté R., Knez D., Gobec S., Malawska B. European journal of medicinal chemistry. 2020, 187