A collaborative work between Nanoscience and Bio-Inorganic Chemistry (nanoBIC) and the Universidade Federal Fluminense (Brazil) describes how two structurally similar metal complexes, [Cu(CPYA)Cl2] (1) and [Pd(CPYA)Cl2], display a distinct behavior against DNA. Their findings highlight the key role of the metal center of potential DNA-targeted metallodrugs.
DNA-interacting properties of two analogous square-planar cis-chlorido complexes: copper versus palladium.
Palmeira-Mello M.V., Caballero A.B., Lopez-Espinar A., Guedes G.P., Caubet A., de Souza A.M.T., Lanznaster M., Gamez P. Journal of Biological Inorganic Chemistry. volume 26, pages727–740 (2021)