Biophysics and Bioengineering Unit

Multi-Step Extracellular Matrix Remodelling and Stiffening in the Development of Idiopathic Pulmonary Fibrosis. Júnior C.; Ulldemolins A.; Narciso M.; Almendros I.; Farré R.; Navajas D.; López J.; Eroles M.; Rico F.; Gavara N. 2023, International Journal of Molecular Sciences, 24, 1708. Doi: 10.3390/ijms24021708

Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin. Narciso M.; Martínez Á.; Júnior C.; Díaz-Valdivia N.; Ulldemolins A.; Berardi M.; Neal K.; Navajas D.; Farré R.; Alcaraz J.; Almendros I.; Gavara N. 2023, Cancers, 15, 8, 2404. Doi: 10.3390/cancers15082404

Fast cycling of intermittent hypoxia in a physiomimetic 3D environment: A novel tool for the study of the parenchymal effects of sleep apnea. Jurado A.; Ulldemolins A.; Lluís H.; Gasull X.; Gavara N.; Sunyer R.; Otero J.; Gozal D.; Almendros I.; Farré R. 2023, Frontiers in Pharmacology,13, 1081345. Doi: 10.3389/fphar.2022.1081345

Development of a physiomimetic model of acute respiratory distress syndrome by using ECM hydrogels and organ-on-a-chip devices. Marhuenda E., Villarino A., Narciso M., Elowsson L., Almendros I., Westergren-Thorsson G., Farré R., Gavara N., Otero J. Frontiers in Pharmacology. 13, 945134, 2022.

Lung Extracellular Matrix Hydrogels Enhance Preservation of Type II Phenotype in Primary Alveolar Epithelial Cells. Marhuenda E., Villarino A., Narciso M.L., Camprubí-Rimblas M., Farré R., Gavara N., Artigas A., Almendros I., Otero J. International Journal of Molecular Sciences, 23, 9, 4888, 2022

Novel Decellularization Method for Tissue Slices. Narciso M., Ulldemolins A., Júnior C., Otero J., Navajas D., Farré R., Gavara N., Almendros I. Frontiers in Bioengineering and Biotechnology, 10, 832178, 2022

Involvement of Mechanical Cues in the Migration of Cajal-Retzius Cells in the Marginal Zone During Neocortical Development. López-Mengual A., Segura-Feliu M., Sunyer R., Sanz-Fraile H., Otero J., Mesquida-Veny F., Gil V., Hervera A., Ferrer I., Soriano J., Trepat X., Farré R., Navajas D., del Río J.A. Frontiers in Cell and Developmental Biology, 10, 886110, 2022

The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening. Andreu I., Falcones B., Hurst S., Chahare N., Quiroga X., Le Roux A.-L., Kechagia Z., Beedle A.E.M., Elosegui-Artola A., Trepat X., Farré R., Betz T., Almendros I., Roca-Cusachs P. Nature Communications. 2021, 12, 1

Mechanical compartmentalization of the intestinal organoid enables crypt folding and collective cell migration. Ceada G., Greco F., Matejčić M., Gómez-González M., Castro N., Menendez A., Kale S., Krndija D., Clark A.G., Gannavarapu V.R., Álvarez-Varela A., Roca-Cusachs P., Batlle E., Vignjevic D.M., Arroyo M., Trepat X. Nature Cell Biology. 2021, 23, 3

Low-cost, easy-to-build noninvasive pressure support ventilator for under-resourced regions: Open source hardware description, performance and feasibility testing. Garmendia O., Rodríguez-Lazaro M.A., Otero J., Phan P., Stoyanova A., Dinh-Xuan A.T., Gozal D., Navajas D., Montserrat J.M., Farré R. European Respiratory Journal. 2020, 55(6)

The conventional isoproterenol-induced heart failure model does not consistently mimic the diaphragmatic dysfunction observed in patients. Cabrera-Aguilera I., Falcones B., Calvo-Fernández A., Benito B., Barreiro E., Gea J., Farré R., Almendros I., Farré N. PLoS ONE. 2020, 15(7)