El grup de Sistemes Supramoleculars en Nanobiomedicina està interessat en el disseny i avaluació de nanopartícules d’or amb diferents conjugats per al tractament del càncer i malalties inflamatòries de la pell. Les principals línies de recerca són:
– Química supramolecular
– Síntesi de plantilles i autoensamblatge en síntesi orgànica
– Hidrogels supramoleculars per al lliurament de medicaments
– Funcionalització de micro / nanopartícules per marcar i actuar en cèl·lules vives
– Nanobiosensors
– Nanopartícules per al lliurament de fàrmacs
– Nanomaterials per a teràpia fotodinàmica
– Interruptors i màquines moleculars
M. Lluïsa Pérez Garcia (Catedràtica) mlperez(at)ub.edu
Bagherpour Saman (Investigador Postdoctoral)
Naga Venkata Lakshmi Kavya Anguluri (Investigadora Predoctoral)
Hina Younis (Investigadora Predoctoral)
Daniela Dupkalová (Investigadora Predoctoral)
Aysha Fasna (Investigadora Predoctoral)
Ruxin Li (Investigadora Predoctoral)
David Limon Magaña (Col·laborador)
Wireless electrical–molecular quantum signalling for cancer cell apoptosis. Jain A.; Gosling J.; Liu S.; Wang H.; Stone E.M.; Chakraborty S.; Jayaraman P.-S.; Smith S.; Amabilino D.B.; Fromhold M.; Long Y.-T.; Pérez-García L.; Turyanska L.; Rahman R.; Rawson F.J. 2023. Nature Nanotechnology. 19, 1. Doi: 10.1038/s41565-023-01496-y
Intrinsic Permeation and Anti-Inflammatory Evaluation of Curcumin, Bisdemethoxycurcumin and Bisdemethylcurcumin by a Validated HPLC-UV Method. Alvarado H.-L.; Limón D.; Calpena-Campmany A.-C.; Mallandrich M.; Rodríguez-Cid L.; Aliaga-Alcalde N.; González-Campo A.; Pérez-García L. 2023, International Journal of Molecular Sciences, 24, 7, 6640. Doi: 10.3390/ijms24076640
Permeation Protection by Waterproofing Mucosal Membranes. Coderch L.; Alonso C.; Calpena A.C.; Pérez-García M.L.; Clares-Naveros B.; Ramos A.; Martí M. 2023, Pharmaceutics, 15, 12, 2698 Doi: 10.3390/pharmaceutics15122698
Supramolecular Hydrogels Consisting of Nanofibers Increase the Bioavailability of Curcuminoids in Inflammatory Skin Diseases. Limón D., Gil-Lianes P., Rodríguez-Cid L., Alvarado H.L., Díaz-Garrido N., Mallandrich M., Baldomà L., Calpena A.C., Domingo C., Aliaga-Alcalde N., González-Campo A., Pérez-García L. ACS Applied Nano Materials, 2022
Gemini Surfactant Mediated Catansomes for Enhanced Singlet Oxygen Generation of Rose Bengal and Their Phototoxicity against Cancer Cells. Sharma B., Samperi M., Jain A., Chaudhary G.R., Kaur G., Pérez-García L. ACS Biomaterials Science and Engineering, 2022
Polysilicon Microchips Functionalized with Bipyridinium-Based Cyclophanes for a Highly Efficient Cytotoxicity in Cancerous Cells. Limón D., Hornick J.E., Cai K., Beldjoudi Y., Duch M., Plaza J.A., Pérez-García L., Stoddart J.F. ACS Nano, 2022
Intracellular Mechanical Drugs Induce Cell-Cycle Altering and Cell Death. Arjona M.I., Duch M., Hernández-Pinto A., Vázquez P., Agusil J.P., Gómez-Martínez R., Redondo-Horcajo M., Amirthalingam E., Pérez-García L., Suárez T., Plaza J.A. Advanced Materials, 2022
An imidazolium-based supramolecular gelator enhancing interlayer adhesion in 3D printed dual network hydrogels. Zhou Z., Samperi M., Santu L., Dizon G., Aboarkaba S., Limón D., Tuck C., Pérez-García L., Irvine D.J., Amabilino D.B., Wildman R. Materials & Design. Volume 206, August 2021, 109792.
Light-controlled micron-scale molecular motion. Samperi M., Bdiri B., Sleet C.D., Markus R., Mallia A.R., Pérez-García L., Amabilino D.B. Nature Chemistry. 2021, 13, 12
Synthesis and validation of DOPY: A new gemini dioleylbispyridinium based amphiphile for nucleic acid transfection. Aubets E., Griera R., Felix A.J., Rigol G., Sikorski C., Limón D., Mastrorosa C., Busquets M.A., Pérez-García L., Noé V., Ciudad C.J. European Journal of Pharmaceutics and Biopharmaceutics. 2021, 165
Enhancing singlet oxygen generation by self-assembly of a porphyrin entrapped in supramolecular fibers. Samperi, M.; Limón, D.; Amabilino, D. B.; Pérez-García, L. Cell Reports Physical Science, 2020, 1, 100030 (1-16)
Lanthanide Luminescence to Mimic Molecular Logic and Computing through Physical Inputs. Hernández-Rodríguez M.A., Brites C.D.S., Antorrena G., Piñol R., Cases R., Pérez-García L., Rodrigues M., Plaza J.A., Torras N., Díez I., Millán A., Carlos L.D. Advanced Optical Materials, 2020
π-Donor/π-Acceptor interactions for the encapsulation of neurotransmitters on functionalized polysilicon-based microparticles. Giraldo S., Alea-Reyes M.E., Limón D., González A., Duch M., Plaza J.A., Ramos-López D., de Lapuente J., González-Campo A., Pérez-García L. Pharmaceutics. 2020, 12(8)
Bio-funcionalización de chips en suspensión innovadores para estudios químicos, bioelectrónicos y mecánicos en células vivas. PID2020-115663GB-C32. IPs: Perez Garcia, M. Luisa and Gomez Valentín, Elvira. Ministerio de Ciencia, Innovación y Universidades. 2021-2024.
(Bio)funcionalización de Suspensiones de Micro- y Nanoherramientas Avanzadas para Aplicaciones Intra- y Extracelulares. TEC2017-85059-C3-2-R. IPs: Perez Garcia, M. Luisa and and Gomez Valentín, Elvira. Ministerio de Economia y Competitividad. 2018-2020.
Collaborating at Wireless communication with cells towards bioelectronic treatments of the future. EP/R004072/1
EPSRC Healthcare Technologies Challenge Awards
Engineering and Physical Sciences Research Council (EPSRC). 2018-2022
– Prof. Fraser Stoddart
Northwestern University, Chicago (US)
– Prof. David Russell/Dra. Ma J. Marin
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich (UK)
– Dr. Frankie Rawson
School of Pharmacy, University of Nottingham (UK)
– Dr. David Scurr
School of Pharmacy, University of Nottingham (UK)
– Prof. Rasmita Raval
School of Chemistry, University of Liverpool (UK)