El grup es dedica a l’aplicació de la nanotecnologia i els biomaterials per al desenvolupament de nous sistemes, protocols i dispositius biomèdics amb l’objectiu de crear noves plataformes de diagnòstic, models i microambients biològics i teràpies regeneratives. Les principals activitats de recerca del grup inclouen l’enginyeria bioquímica, les tècniques de litografia en soft i la microfabricació, la funcionalització de biomaterials integrats amb sistemes microfluídics i la plataforma tridimensional de biomaterials biodegradables i bioactius.
Josep Samitier Martí (Catedràtic) jsamitier(at)ub.edu
Oscar Castaño Linares (Agregat) oscar.castano(at)ub.edu
Jordi Colomer Farrarons (Agregat) jcolomerf(at)ub.edu
Romén Rodríguez Trujillo (Agregat)
Mònica Mir Llorente (Associada)
Adrià Noguera (Investigador Predoctoral)
Ximenes-Carballo C.; Rey-Viñolas S.; Blanco-Fernandez B.; Pérez-Amodio S.; Engel E.; Castano O. Combining three-dimensionality and CaP glass-PLA composites: Towards an efficient vascularization in bone tissue healing. Biomaterials Advances. Volume 164, November 2024, 213985. 10.1016/j.bioadv.2024.213985.
Prat-Trunas J.; Arias-Alpizar K.; Álvarez-Carulla A.; Orio-Tejada J.; Molina I.; Sánchez-Montalvá A.; Colomer-Farrarons J.; del Campo F.J.; Miribel-Català P.L.; Baldrich E. Paper-based microfluidic electro-analytical device (PMED) for magneto-assay automation: Towards generic point-of-care diagnostic devices. 2024, Biosensors and Bioelectronics, 246, 115875. 10.1016/j.bios.2023.115875.
BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease. Palma-Florez S.; López-Canosa A.; Moralez-Zavala F.; Castaño O.; Kogan M.J.; Samitier J.; Lagunas A.; Mir M. 2023, Journal of Nanobiotechnology, 21, 1, 115. Doi: 10.1186/s12951-023-01798-2
Cooperativity and oscillations: Regulatory mechanisms of K-Ras nanoclusters. Jurado M.; Zorzano A.; Castaño O. 2023, Computers in Biology and Medicine, 166, 107455. Doi: 10.1016/j.compbiomed.2023.107455
Microfluidic-Assisted Interfacial Complexation of Extracellular Matrix Components to Mimic the Properties of Neural Tissues. Costa R.R.; Caballero D.; Soares da Costa D.; Rodriguez-Trujillo R.; Kundu S.C.; Reis R.L.; Pashkuleva I. 2023, Advanced Materials Technologies, 8, 19, 2300983. Doi: 10.1002/admt.202300983
Microfluidic 3D platform to evaluate endothelial progenitor cell recruitment by bioactive materials. López-Canosa A., Pérez-Amodio S., Engel E., Castaño O. Acta Biomaterialia, 2022
Development of a Custom-Made 3D Printing Protocol with Commercial Resins for Manufacturing Microfluidic Devices. Subirada F., Paoli R., Sierra-Agudelo J., Lagunas A., Rodriguez-Trujillo R., Samitier J. Polymers, 14, 14, 2955, 2022
Trackability of distal access catheters: An in vitro quantitative evaluation of navigation strategies. Li J., Tomasello A., Requena M., Canals P., Tiberi R., Galve I., Engel E., Kallmes D.F., Castaño O., Ribo M. Journal of NeuroInterventional Surgery, 2022
A microphysiological system combining electrospun fibers and electrical stimulation for the maturation of highly anisotropic cardiac tissue. López-Canosa A., Perez-Amodio S., Yanac-Huertas E., Ordoño J., Rodriguez-Trujillo R., Samitier J., Castaño O., Engel E. Biofabrication, 2021, 13, 3
Stochastic modulation evidences a transitory EGF-Ras-ERK MAPK activity induced by PRMT5. Jurado M., Castaño Ó., Zorzano A. Computers in Biology and Medicine. 2021, 133
Chemotactic TEG3 Cells’ Guiding Platforms Based on PLA Fibers Functionalized With the SDF-1α/CXCL12 Chemokine for Neural Regeneration Therapy. Castaño O., López-Mengual A., Reginensi D., Matamoros-Angles A., Engel E., del Rio J.A. Frontiers in Bioengineering and Biotechnology. 2021, 9
Micro-needle implantable electrochemical oxygen sensor: ex-vivo and in-vivo studies. Rivas L., Dulay S., Miserere S., Pla L., Marin S.B., Parra J., Eixarch E., Gratacós E., Illa M., Mir M., Samitier J. Biosensors and Bioelectronics, 2020. 153, 112028
Sensor-integrated microfluidic approaches for liquid biopsies applications in early detection of cancer. Sierra J., Marrugo-Ramírez J., Rodriguez-Trujillo R., Mir M., Samitier J. Sensors. 2020, 20(5)
Engineering Cell-Derived Matrices: From 3D Models to Advanced Personalized Therapies. Rubi-Sans G., Castaño O., Cano I., Mateos-Timoneda M.A., Perez-Amodio S., Engel E. Advanced Functional Materials. 2020, 30(44)
Layer-by-layer modification effects on a nanopore’s inner surface of polycarbonate track-etched membranes. Paoli R., Bulwan M., Castaño O., Engel E., Rodriguez-Cabello J.C., Homs-Corbera A., Samitier J. RSC Advances. 2020, 10(59)
Plataforma microfluídica integrada como modelo de miocardio electrofisiológicamente relevante. PID2021-124575OB-I00. IP: Oscar Castaño Linares. Convocatoria 2021 de ayudas a «Proyectos de Generación de Conocimiento». Modalidad Proyectos de «Investigación Orientada». Ministerio de Ciencia e Innovación (MICINN). (2022-2025)
Red de organoides neuronales humanos para el descubrimiento de fármacos (ACE053/22/000086). ACE053/22/000086. IP: Oscar Castaño Linares. ACCIÓ. Agència de Suport a l’Empresa Catalana (2022-2025)
Plataformas microfisiológicas in vitro para la mimetización de las barreras del sitema nervioso central: aplicaiones en cerebro y médula espina. RTI2018-097038-B-C22. Ministerio de Ciencia, Innovación y Universidades. PI1: Oscar Castaño/ PI2: Romen Rodriguez. 2019-2021
Nanofabrication and nanomanipulation
• 3D Printing system for microfluidic devices
• Soft lithography en microfabrication techniques
• Graphtech
• Electrospinning device
• Spin-coater
• Combustion furnace
• High temperature furnace
• Ball mill
• Inert atmosphere facilities
• Sol-gel facilities
Characterization
• Potentiostates
• Optical Waveguide Lightmode Spectroscope (OWLS)
• Atomic Force Microscope (AFM)
• Optical Microscopes (white light/epifluorescence)
• Electrical Impedance spectroscopy (EIS)
• Multi-frequency Lock-in Amplifier
• Sub-femtoamp Remote SourceMeter Instrument
• Surface characterization equipment (contact angle, Z potential)
• Differential Scanning Calorimetry (DSC)
• Soft tissue mechanical testing machine
• Peptide synthesizer
• Vibrational viscosimeter
Molecular/cell biology
• Cell culture facilities
• Molecular Biology equipment: protein and DNA electrophoresis
• Thermocycler (PCR)
• Biological safety cabinet (class II)
• Microwell plate readers
• Protein and DNA electrophoresis systems
• Microincubator Okolab
• Nanodrop spectrophotometer
• CO2 incubator for cells
• Cell culture cabin
Microfluidics
• High precision syringe pumps
• Peristaltic pumps
Dr. Adrian Carretero, Institut d’Electronique et des Systèmes, Montpellier, France
Dr. Graham Johnson, Uniscan Instruments Ltd, Buxton, UK
Dr. Izabella Rajzer Institute of Textile Engineering and Polymer Materials, University of Bielsko-Biala, Poland
Dr. Nicole Jaffrezic, Université Claude Bernard Lyon 1, France
Prof. Albert Folch, Dpt. of Bioengineering, University of Washington, USA
Prof. Albert van den Berg, University of Twente, The Netherlands
Prof. Andre Bernard, Institut für Mikro- und Nanotechnologie (MNT-NTB), Buchs, Switzerland
Prof. E. Faszewski, Wheelock College, Boston, USA
Prof. G. Fuhr, FhG Biomedicine, St. Ingbert, Germany
Prof. H. Börner Max, Planck Institute of Colloids and Interfaces, Golm, Germany
Prof. Jean-Louis Marty, U. de Perpignan Via Domitia, France
Prof. Juan C. Izpisúa, Salk Institute for Biological Studies, La Jolla, California
Prof. Kevin Healy Biomaterials & Tissue Engineering Laboratory, University of California at Berkeley, USA
Prof. Matthew Dalby, University of Glasgow, UK
Prof. Paolo Dario, Scuola Superiore Sant’Anna (SSSA), Pontedera, Italy
Prof. Roger D. Kamm, Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, USA