Accessit 2

El continuum de la enfermedad de Alzheimer (EA) comprende diferentes etapas desde una larga fase preclínica hasta el desarrollo de demencia. Los procesos fisiopatológicos que rigen su progresión pueden ser estudiados con biomarcadores.

El soporte de tela de los cuadros se compone mayoritariamente de celulosa. Una de las vias de degradación de la celulosa es la hidrólisis ácida, que implica que en un ambiente ácido (bajo pH), la degradación se produce a una velocidad mayor. La principal consecuencia de esta acidez es la ruptura de las cadenas del polímero de celulosa que se mide a través del grado de polimerización (DP).

The present dissertation, which can be framed in the fields of behavioural and psychiatric genetics, was aimed to study how early environmental factors such as parental negativity and childhood adversity, directly or in interaction with genetic factors account for psychopathological variation (subclinical and clinical psychiatric symptoms) in general populatiol including childhood behavioural p

This PhD has pursued three different and interconnected objectives, each corresponding to one of the three parts of the PhD. In Part I, a historical reconstruction is provided in order to present the background against which some political paradoxes in the present have to be understood in relation to globalization.

Parkinson's disease (PD) is a neurodegenerative disorder characterized by movement impairment, or parkinsonism, for which there is still no cure. The manifest clinical signs result from neuronal loss of more than 60% in the substantia nigra pars compacta. Cognitive disorders and dementia in PD usually occur, thus leading to Parkinson disease with dementia (PDD).