Details

Position

Post Doc

First Name

Sergi

Last Name

Ruiz Carmona

Title

5 : PhD

Project

I am interested in the combination of computational and experimental techniques in Drug Discovery processes.
In particular, my PhD project involved different methodologies such as:

• Molecular Docking.
• High Throughput Virtual Screening.
• Experimental techniques:
  • Surface Plasmon Resonance.
  • Differential Scanning Fluorimetry.
  • in vivo assays.
• Molecular Dynamics.
• Chemoinformatic tools.

My main project was focused in finding small-molecules capables of binding in Protein-Protein Interfaces which increase their affinity.
Thus, as a proof of concept, we worked in a system formed by two E.Coli proteins, CheA and CheY. This system was selected applying cavity detection algorithms and druggability prediction methodologies developed in our group. 
 
I have also participated in collaborative projects with pharmaceutical companies, applying computational techniques in real R&D campaigns for drug discovery.

History

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Member for

13 years 40 weeks

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