OBJECTIVES

1. • To investigate new alternative cancer therapies using the developments in Biochemistry and Molecular Biology. 
   

2. • To improve our technology of Polypurine Reverse Hoogsteen hairpins (PPRHs) for gene silencing, gene repair, gene editing and as biosensors for diagnostics
   

3. • To explore new delivery systems for oligonucleotide transfection in vitro and in vivo
   

 

RESEARCH INTERESTS

1. •   Design and usage of polypurine hairpins against gene expression: Studies in vitro and in vivo
   

2. •    Developing new liposomes, transfection agents and AAV particles to deliver the PPRHs.
   

3. •    To repair DNA mutations at the endogenous locus using Polypurine Hairpins.
   

4. •    To investigate the role of alternative splicing on the expression of proteins.
   

5. •    To develop PPRHs against non-druggable targets such as k-Ras and c-Myc
   

6. •    To develop PPRHs against PCSK9 to decrease cholesterol levels
   

7. •    Genomic studies related to Methotrexate resistance, including LncRNAs
   

8. •     Networking of differentially expressed genes in methotrexate resistant cells.

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