Monitoring and modulation of brain circuits in brain disorders. PI: Mercè Masana Nadal

Mercè Masana Nadal
Associate professor
mmasana@ub.edu

 

Anna Castañé Forn
Collaborating researcher
anna.castane@ub.edu

 

Maryam Givehchi
Pre-doctoral researcher
maryam.givehchi@ub.edu

 

Melike Kucukerden
Post-doctoral researcher
kucukerden@ub.edu

 

Laia Sitjà Roqueta
Pre-doctoral researcher
laiasitja@ub.edu

 

PAST MEMBERS:

 

Sara Conde Berriozábal
Pre-doctoral researcher
saraconde@ub.edu

 

Esther García-García
Pre-doctoral researcher
egarcia92@ub.edu

• Next Generation Glioma Treatments using Direct Light Therapy

• Next Generation Glioma Treatments using Direct Light Therapy (GlioLighT)

Project reference: HORIZON-EIC-2023-PATHFINDEROPEN-01-01 (101129705)
Principal Investigator: Mercè Masana Nadal
Affiliation entity: Universitat de Barcelona
Funding entity: European Innovation Council
Amount: 611.572,50 €
Period: 2023 -

• Can visual perception integration in the superior colliculus shape resilience to motor symptoms in neurodegenerative disorders?

Project reference: PID2021-124896OA-I00
Principal Investigator: Mercè Masana Nadal
Affiliation entity: Universitat de Barcelona
Funding entity: Ministerio de Ciéncia e Innovación
Amount: €
Period: 2022 - 2024

• Non-invasive dynamic neural control by laser-based technology (NEUROPA)

Project reference: 863214
Principal Investigator: Mercè Masana Nadal
Affiliation entity: Universitat de Barcelona
Funding entity: EUUN - European union
Amount: 451.070,00 €
Period: 2020 - 2022

• Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

Project reference: 21613
Principal Investigators: Jordi Alberch Vié, Manuel José Rodriguez Allué and Mercè Masana Nadal
Affiliation entity: Universitat de Barcelona
Funding entity: Fundació ChAC
Amount: 50.000,00 €
Period: 2018 - 2021

• Validation of two pharmaceutical compounds provided by Esteve Pharmaceuticals, S.A. in models of Huntington's disease (HD)

Project reference: Contract
Principal Investigators: Jordi Alberch Vié and Mercè Masana Nadal
Affiliation entity: Universitat de Barcelona
Funding entity: Esteve Pharmaceuticals, S.A
Amount: 58.850,00 €
Period: 2019 - 2020

For more information for PI publications click in the link:

ORCID: 0000-0003-1392-4774
Research ID: K-5302-2014

 

García-García, E., Ramón-Lainez, A., Conde-Berriozabal, S., del Toro, D., Escaramis, G., Giralt, A., Masana, M., Alberch, J., Rodríguez, M.J., 2023. VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis. Neurobiol. Dis. 187, 106292.

Xu, Q., Vogt, A., Frechen, F., Yi, C., Küçükerden, M., Ngum, N., Sitjà-Roqueta, L., Greiner, A., Parri, R., Masana, M., Wenger, N., Wachten, D., Möglich, A., 2023. Engineering Bacteriophytochrome-coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic cAMP Modulation. J. Mol. Biol. 168257.

Solana‐Balaguer, J., Campoy‐Campos, G., Martín‐Flores, N., Pérez‐Sisqués, L., Sitjà‐Roqueta, L., Kucukerden, M., Gámez‐Valero, A., Coll‐Manzano, A., Martí, E., Pérez‐Navarro, E., Alberch, J., Soriano, J., Masana, M., Malagelada, C., 2023. Neuron-derived extracellular vesicles contain synaptic proteins, promote spine formation, activate TrkB-mediated signalling and preserve neuronal complexity. J. Extracell. Vesicles 12, e12355–e12355.

Conde-Berriozabal, S., García-Gilabert, L., García-García, E., Sitjà-Roqueta, L., López-Gil, J., Muñoz-Moreno, E., Boudjadja, M.B., Soria, G., Rodríguez, M.J., Alberch, J., Masana, M. M2 Cortex Circuitry and Sensory-Induced Behavioral Alterations in Huntington's Disease: Role of Superior Colliculus. J Neurosci. 2023 May 3; 43(18): 3379-3390. doi: 10.1523/ JNEUROSCI.1172-22.2023. Epub 2023 Mar 31. PMID: 37001992

López-Terrones, E., Paz, V., Campa, L., Conde-Berriozabal, S., Masana, M., Artigas, F., Riga, M.S. Differential Modulation of Dorsal Raphe Serotonergic Activity in Rat Brain by the Infralimbic and Prelimbic Cortices. Int. J. Mol. Sci. Mar 3;24(5): 4891. doi: 10.3390/ ijms24054891. pmid: 36902322

Veronica Brito; Enrica Montalban; Anna Sancho-Balsells, Anika Pupak; Francesca Flotta, Mercè Masana; Silvia Ginés; Jordi Alberch; Claire Martin; Jean-Antoine Girault; Albert Giralt. Hippocampal Egr1-dependent neuronal ensembles negatively regulate motor learning. J. Neurosci  2022 Jul 6;42(27):5346-5360. doi: 10.1523/ JNEUROSCI. 2258-21.2022. Epub 2022 May 24. PMID: 35610044

Pérez-Sisqués, L., Solana-Balaguer, J., Campoy-Campos, G., Martín-Flores, N., Sancho-Balsells, A., Vives-Isern, M., Soler-Palazón, F., Garcia-Forn, M., Masana, M., Alberch, J., Pérez-Navarro, E., Giralt, A., Malagelada, C., 2021. RTP801/REDD1 Is Involved in Neuroinflammation and Modulates Cognitive Dysfunction in Huntington’s Disease. Biomolecules 2021, Dec 27;12(1):34. doi: 10.3390/ biom12010034. https://doi.org/10.3390/biom12010034. PMID: 35053183

Esther García-García , Nerea Chaparro-Cabanillas, Albert Coll-Manzano, María Carreras-Caballé, Albert Giralt, Daniel Del Toro, Jordi Alberch, Mercè Masana* and Manuel J Rodríguez*. Unravelling the spatiotemporal distribution of VPS13A in the mouse brain. Int. J. Mol. Sci. Dec. 2021, 22(23), 13018; IF: 5.923.

Pérez-Sisqués, L., Martín-Flores, N., Masana, M., Solana-Balaguer, J., Llobet, A., Romaní-Aumedes, J., Canal, M., Campoy-Campos, G., García-García, E., Sánchez-Fernández, N., Fernández-García, S., Gilbert, J.P., Rodríguez, M.J., Man, H.Y., Feinstein, E., Williamson, D.L., Soto, D., Gasull, X., Alberch, J., Malagelada, C., 2021. RTP801 regulates motor cortex synaptic transmission and learning. Exp. Neurol. 342. Aug. 2021.113755. IF: 5.33 –Q2–Neuroscience.

Masana, M., Rodríguez, M.J., Alberch, J., 2021. Proceedings of the Tenth International Meeting on Neuroacanthocytosis Syndromes. Tremor and Other Hyperkinetic Movements May 2021; 11(1):19.  IF: N/A. 

Creus-Muncunill, J., Guisado-Corcoll, A., Venturi, V., Pantano, L., Escaramís, G., García de Herreros, M., Solaguren-Beascoa, M., Gámez-Valero, A., Navarrete, C., Masana, M., Llorens, F., Diaz-Lucena, D., Pérez-Navarro, E., Martí, E., Feb. 2021. Huntington’s disease brain-derived small RNAs recapitulate associated neuropathology in mice. Acta Neuropathol. 141, 565–584. IF: 17.088 –D1–Neuroscience.

Sara Fernández-García, Sara Conde-Berriozábal, Esther García-García, Clara Gort-Paniello , David Bernal-Casas, Gerardo García-Díaz Barriga, Javier López-Gil, Emma Muñoz-Moreno, Guadalupe Sòria, Leticia Campa, Francesc Artigas, Manuel José Rodríguez, Jordi Alberch and Mercè Masana (2020). M2 Cortex-Dorsolateral striatum stimulation reverses motor symptoms and synaptic deficits in Huntington's Disease. eLife 2020;9:e57017. DOI: org/10.7554/ eLife. 57017. IF: 8.140 –D1–Biology. PMID: 33016873.

Núria Martín-Flores, Leticia Pérez-Sisqués, Jordi Creus-Muncunill, Mercè Masana, Silvia Gines, Jordi Alberch, Esther Perez-Navarro and Cristina Malagelada  (2020). Synaptic RTP801 contributes to motor learning dysfunction in huntington’s disease. Cell Death & Disease. IF: 8.469 -Q1-Cell Biology. doi.org/10.1101/2020.04.07.030080.

Fernández-García, J. G. Orlandi, A. García-Díaz Barriga, M. J. Rodríguez, M. Masana, J. Soriano, J. Alberch (2020). Deficits in coordinated neuronal activity and network topology are striatal hallmarks in Huntington’s Disease. BMC Biology (18) 58. IF:7.431 –Q1–Biology. doi.org/10.1186/ s12915-020- 00794-4.

Anya Kim, Esther García-García, Marco Straccia, Andrea Comella-Bolla, Andrés Miguez, Mercè Masana, Jordi Alberch, Josep M. Canals, Manuel J Rodríguez (2020). Reduced Fractalkine Levels Lead To Striatal Synaptic Plasticity Deficits In Huntington’s Disease. Accepted in Frontiers in Cellular Neuroscience. IF: 5.505 –Q1–Neuroscience. doi.org/ 10.3389/fncel.2020.00163.

Jordi Creus-Muncunill, Raquel Badillos-Rodríguez, Marta Garcia-Forn, Mercè Masana, Gerardo Garcia-Díaz Barriga, Anna Guisado-Corcoll, Jordi Alberch, Cristina Malagelada, José M. Delgado-García, Agnès Gruart, Esther Pérez-Navarro (2019). Increased translation as a novel pathogenic mechanism in Huntington’s disease. Brain Oct 1;142(10): 3158-3175. doi: 10.1093/ brain/awz230. IF: 11.814 –D1–Neuroscience. PMID: 31365052.

Brito V, Giralt A, Masana M, Royes A, Espina M, Sieiro E, Alberch J, Castañé A, Girault JA, Ginés S (2019). Cyclin-Dependent Kinase 5 Dysfunction Contributes to Depressive-like Behaviors in Huntington's Disease by Altering the DARPP-32 Phosphorylation Status in the Nucleus Accumbens. Biol Psychiatry. 2019 Mar 13. pii: S0006-3223(19) 30151-9. doi: 10.1016 /j.biopsych. 2019.03.001. IF: 11.501 –D1–Neuroscience. PMID: 31060804.

Glòria Blázquez; Anna Castañé; Ana Saavedra; Mercè Masana; Jordi Alberch; Francesc Artigas; Esther Pérez-Navarro (2019). Social memory and social patterns alterations in the absence of STriatal-Enriched protein tyrosine. Phosphatase. Frontiers In Behavioral Neuroscience. https://doi.org/ 10.3389/fnbeh. 2018.00317. IF: 2.622 –Q2–Frontiers in Behavioral Neuroscience. PMID: 30760987.

Kretzschmar A, Schülke JP, Masana M, Dürre K, Müller MB, Bausch AR, Rein T (2018). The Stress-Inducible Protein DRR1 Exerts Distinct Effects on Actin Dynamics. Int J Mol Sci. 19(12). pii: E3993. doi: 10.3390/ ijms19123993. IF: 4.183 –Q2–Biochemistry ¬molecular biologyology. PMID: 30545002.

M. Masana, S. Westerholz, A. Kretzschmar, G. Treccani, C. Liebl, S. Santarelli, C. Dournes, M. Popoli, M.V. Schmidt, T. Rein, M.B. Müller (2018). Expression and glucocorticoid-dependent regulation of the stress-inducible protein DRR1 in the mouse adult brain. Brain Structure and Function. doi: 10.1007/s00429-018-1737-7. (Autor de correspondència) IF: 4.2-D1-Anatomy and morphology. PMID: 30121783.

N. Cabezas-Llobet, L. Vidal-Sancho, M. Masana, A. Fournier, J. Alberch, D. Vaudry, X.Xifró (2018). Pituitary adenylate cyclase-activating polypeptide (PACAP) enhances hippocampal synaptic plasticity in Huntington’s disease by up-regulation of PAC1 receptor expression. Molecular Neurobiology doi: 10.1007/ s12035-018-0972-5. PMID: 29526016.

S. Santarelli, C. A. Zimmermann, G. Kalideris, S. L. Lesuis, J. Arloth, A. Uribe, C. Dournes, G. Balsevich, J. Hartmann, M. Masana, E. Binder, D. Spengler, M. Schmidt (2017). An adverse early life environment can enhance stress resilience in adulthood. Psychoneuroendocrinology 78:213-221. IF: 5.135 Q1–Neuroscience. doi: 10.1016 /j.psyneuen. 2017.01.021. Epub 2017 Feb 7. PMID: 28219813.

A. Uribe-Mariño, N. C. Gassen, M. F. Wiesbeck, G. Balsevich1, S. Santarelli, B. Solfrank, C. Dournes, G. R. Fries, M. Masana, C. Labermeier, X-D. Wang, K. Hafner, B. Schmid, T. Rein, A. Chen, J.M. Deussing, M. V. Schmidt (2016). Prefrontal cortex corticotropin-releasing hormone receptor 1 conveys acute stress induced executive dysfunction. Biological psychiatry 80(10):743-753. IF: 9.472 –Q1–Neuroscience. doi: 10.1016 /j.biopsych. 2016.03.2106. Epub 2016 Apr 8. PMID: 27318500.

M.A. van der Kooij*, M. Masana*, M. Rust, M.B. Müller (2016). The stressed cytoskeleton: how neuronal actin dynamics can shape stress-related consequences on synaptic plasticity and complex behaviour. Neuroscience & Biobehavioral Reviews 62:69-75. IF: 8.802 –Q1–Neuroscience *Co-primera autora. doi: 10.1016 / j.neubiorev.  2015.12.001. Epub 2015 Dec 12. PMID: 26691726.

S. Santarelli, K. V. Wagner, C. Labermaier, A. Uribe, C. Dournes, G. Balsevich, J. Hartmann, M. Masana, F. Holsboer, A. Chen, M. B. Müller, M. V. Schmidt (2016). SLC6A15, a novel stress vulnerability candidate, modulates anxiety and depressive-like behavior: involvement of the glutamatergic system. Stress 19(1):83-90. IF:2.715 –Q2–Behavioral Sciences. doi: 10.3109/ 10253890. 2015.1105211. Epub 2015 Nov 20. PMID: 26585320.

M. Masana, M. M. Jukic, A. Kretzschmar, K.V. Wagner, S. Westerholz, M.V. Schmidt, T. Rein, C. Brodski, M.B. Müller (2015). Deciphering the spatio-temporal expression and stress regulation of Fam107B, the paralog of the resilience-promoting protein DRR1 in the mouse brain. Neuroscience 290:147–158. (Autor de correspondència) IF:3.327 –Q2–Neuroscience. doi: 10.1016 /j.neuroscience. 2015.01.026. Epub 2015 Jan 28. PMID: 25637808.

S. Filser, S.V. Ovsepian, M. Masana, L. Blazquez-Llorca, A.B. Elvang, C. Volbracht, M.B. Müller, CKE. Jung, J. Herms (2015). Pharmacological Inhibition of BACE1 Can Impair Synaptic Plasticity and Cognitive Functions. Biological psychiatry 77(8):729–739. IF: 9.472 –Q1–Neuroscience. doi: 10.1016 /j.biopsych. 2014.10.013. Epub 2014 Oct 29. PMID: 25599931.

M. Masana*, Y-A. Su*, C. Liebl, X-D. Wang, L. Jansen, S. Westerholz, K.V. Wagner, C. Labermaier, S.H. Scharf,  S. Santarelli, J. Hartmann, M.V. Schmidt, T. Rein, M.B. Müller (2014). The stress-inducible actin-interacting protein DRR1 shapes social behaviour. Psychoneuroendocrinology 48:98-110. *Co-primera autora i autora de correspondència. IF: 5.135 –Q1–Neuroscience.  doi: 10.1016 /j.psyneuen. 2014.06.009. Epub 2014 Jun 19. PMID: 24998413.

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