Doctorat Medicina

The basic objective of research of the group is to increase knowledge and understanding of the human genetic variability and its toxicological, medical and forensic consequences.

Projects financed:

SUSCEPTIBILIDAD GENÉTICA A LOS EFECTOS TÓXICOS DEL PLOMO. INFLUENCIA DEL GENOTIPO DEL ENZIMA DELTA-AMINOLEVULÍNICO ÁCIDO DESHIDRATASA EN LA TOXICINÉTICA DEL PLOMO. FISS . REF. PI020023

The aim of the group is to promote research in the most prevalent chronic arthritis, rheumatoid arthritis and spondylarthritis. The main lines of research are: - Prognostic factors in recent onset arthritis.- Antibodies against citrulline-containing peptides in rheumatoid arthritis: diagnostic and prognostic value. - Angiogenesis in recent onset arthritis Prognostic value of angiogenesis; effect of biological therapies on synovial angiogenesis. - Synovial neolymphogenesis in rheumatoid arthritis and psoriatic arthritis. - Intermittent arthritis. Clinical and immunogenetic characterisation. - Efficiency and safety of biological therapies (TNF antagonists) in rheumatoid arthritis and spondyloarthropathies.

Projects financed:

Systemic autoimmune diseases group promotes basic and clinical research on systemic autoimmune diseases from a multidisciplinary point of view, with the participation of members of Autoimmune Diseases, Nephrology, Immunology, Haemotherapy, Hepatology and Dermatology Coordination Services. However, these activities are carried out in collaboration with various international work groups promoted by the European Union: European Working Party on Systemic Lupus Erythematosus (EWPSLE), European Forum on Antiphospholipid Antibodies (EFAPL), and the Systemic Lupus International Centres(SLICC). The CAPS Registry, coordinated by our group, has also been started. It is devoted to the study of the catastrophic antiphospholipid antibody syndrome. New lines of research concern the experimental model in mice, autoimmune manifestations induced by HCV, pathogenic mechanisms of systemic lupus erythematosus, Sjögren's syndrome and assessment of the cardiovascular risk factors of these diseases.

Projects financed:

ALTERACIONES GENÉTICAS EN EL FUNCIONALISMO PLAQUETARIO, LA FIBRINOLISIS Y EL SISTEMA INMUNITARIO INNATO COMO FACTORES PREDISPONENTES DE ARTERIOSCLEROSIS PRECOZ EN PACIENTES CON LUPUS ERITEMATOSO SISTÉMICO. FONDO DE INVESTIGACIONES SANITARIAS DE LA SEGURIDAD SOCIAL . REF. PI030280
MARCADORES BIOLOGICOS EL FRACASO MULTIORGANICO EN EL SHOCK SEPTICO INSTITUTO DE SALUD CARLOS III. FIS . REF. PI050164
HETEROGENEIDAD GENÓMICA VIRAL Y ALTERACIONES DE LA INMUNIDAD INNATA COMO FACTORES ETIOPATOGÉNICOS DE ENFERMEDAD AUTOINMUNE EN PACIENTES CON INFECCIÓN CRÓNICA POR EL VIRUS DE LA HEPATITIS C F.I.S . REF. PI04/0701

Lines of research in the field of AIDS: - Immunotherapy of the disease, natural and acquired defence mechanisms, including the development of therapeutic vaccines. - Efficiency, mechanisms of resistance and tolerance of new antiretroviral drugs. - Immunopathogenicity, response to treatment and resistance mechanisms of some OI¿s including tuberculosis, PCP and toxoplasmosis. Lines of research in the field of general infections: - Prophylaxis and support to treatment of endocarditis caused by multiresistant germs, including experimental models. - Infections in solid organ transplant recipients. - Interactions between nosocomial infections and the use of antibiotics. - Pathogenicity and diagnostic markers of recurrent urinary tract infection. - Diagnosis of respiratory viruses in hospital-acquired and community-acquired pneumonia. Members of the Infectious Diseases and Microbiology Unit of Hospital Clínic de Barcelona, belong to these lines of research. Their research activity is primarily focused in AIDS and includes most of the research activity concerning infectious diseases and microbiology.

Projects financed:

ESTUDIO EN FASE I DE IMMUNOGENICIDAD DE UNA VACUNA PREVENTIVA PARA EL VIH BASADA EN UN VECTOR POXVIRUS QUE EXPRESSA PROTEINAS ENV, GAG, POL Y NEF DEL VIH-1 SUBTIPO B EN INDIVIDUOS NO INFECTADOS POR EL VIH FIS . REF. PI050058
ESTUDIO DE LA RESPUESTA INMUNITARIA ¿IN VITRO?A UNA VACUNA TERAPÉUTICA CONTRA EL VIH-1 PREPARADA CON CÉLULAS DENDRÍTICAS MIELOIDES AUTOLOGAS PULSADAS CON DIFERENTES INMUNOGENO. FUNDACIÓ PRIVADA CLÍNIC PER LA RESERCA BIOMÈDICA. . REF. SAF 2005-05566
INVESTIGAR LA RELACIÓN ENTRE LA RESISTENCIA A QUINOLONAS Y VIRULENCIA EN ASISLAMIENTOS CLÍNICOS DE ESCHERICHIA COLI SALMONELLA SPP Y YERSINIA ENTEROCOLÍTICA FIS . REF. PI050097
DIAGNOSTICO DE LA NEUMONÍA POR VIRUS RESPIRATORIOS, CLAMYDOPHILA PNEUMONIAE Y MYCOPLASMA PNEUMONIAE EN EL PACIENTE INMUNODEPRIMIDO MEDIANTE PCR A TIEMPO REAL FIS . REF. PI 060270
COMPARACIÓN DE DOS ESTRATEGIAS DE USO DE ANTIBIÓTICOS CON ACTIVIDAD ANTI-P. AERUGINOSA (ROTACIÓN FRENTE A MEZCLA) EN LA ADQUISICIÓN DE BACILOS GRAM NEGATIVOS RESISTENTES EN PACIENTES INGRESADOS EN UNA UNIDAD DE CUIDADOS INTENSIVOS. FIS . REF. PI050167
ESTUDIO PILOTO DEL TRATAMIENTO INMUNOMEDIADO DE LA INFECCIÓN AGUDA DEL VIH CON EL FIN DE INDUCIR UNA FUERTE RESPUESTA INMUNOESPECÍFICA FRENTE AL VIH QUE PERMITA EL CONTROL DE LA REPLICACIÓN VIRAL SIN TRATAMIENTO ANTIRETROVIRAL (TRAV) FIS-ISCIII . REF. PI 040363
CARACTERIZACION EX VIVO DE LA RESPUESTA INMUNITARIA CELULAR FRENTE AL VIH-1 MEDIANTE VECTORES VIRALES FONDO DE INVESTIGACIONES SANITARIAS (FIS) . REF. FIS PI070291

Our group has unified the former Research Group on Epidemiology and International Health and Research Group on Public Health and Nosocomial Infections. The new group has the aim to conduct research involving public health, epidemiology, prevention and control of transmittable diseases. One of the main pillars of our activity is the fight against the main causes of morbidity and mortality affecting children under 5 years and pregnant women in Sub-Saharan Africa. Most of the research lines are devoted to diseases defined as related to poorness, but there is also a line devoted to diseases imported to Spain and their epidemiological surveillance.

Projects financed:

AGE EXPOSURE AND IMMUNITY TO MALARIA IN INFANTS 6È PROGRAMA MARC DE LA UNIÓ EUROPEA . REF. LSHP-CT-2005
ANÁLISIS DE LA VARIABILIDAD ESPACIAL Y TEMPORAL DEL PRODUCTO DE LA ATENCIÓN PRIMARIA EN CATALUÑA. FIS . REF. IP 061581
EVALUACIÓN DE 4 COMBINACIONES DE ARTEMISINA PARA EL TRATAMIENTO DE LA MALARIA NO COMPLICADA EN NIÑOS DE AFRICA INSTITUTO DE SALUD CARLOS III . REF.
ESTUDI DE LA INFECCIÓ PER TRIPANOSOMA CRUZI EN LA POBLACIÓ IMMIGRANT D?AMÈRICA CENTRAL I DEL SUD. AATRM (AGÈNCIA D'AVALUACIÓ TECNOLÓGICA I DE RECERCA MÈDICA) . REF. 024/013/2004
EVALUACIÓN DE LAS PAUTAS ACTUALES Y DE NUEVOS ANTIBIÓTICOS EN EL TRATAMIENTO DE LA ENDOCARDITIS EXPERIMENTAL EN CONEJOS POR STAPHYLOCOCCUS EPIDERMIS RESISTENTES A LA METICILINA (SERM) O CON SENSIBILIDAD DISMINUIDA A LOS GLUCOPÉPTIDOS (GISE) FIS . REF. 05/170
CARACTERIZACIÓN DEL LIGANDO DE P.FALCIPARUM IMPLICADO EN ADHESIÓN A LA PLACENTA Y DE SU PAPEL EN EL DESARROLLO DE LA INMUNIDAD FRENTE A LA MALARIA DURANTE EL EMBARAZO INSTITUTO DE LA SALUD CARLOS III . REF. PI060016
EVALUACIÓN DE 4 COMBINACIONES DE ARTEMISINA PARA EL TRATAMIENTO DE LA MALARIA NO COMPLICADA EN NIÑOS DE AFRICA INSTITUTO DE SALUD CARLOS III . REF.
EXPOSICIONES AL VIRUS DE LA VARIZELA-ZOSTER O CONTACTOS SOCIALES CON NIÑOS Y OCURRENCIA DE HERPES-ZOSTER EN ADULTOS. ESTUDIO DE CASOS Y CONTROLES FIS . REF. PI061045
CARACTERIZACIÓN, INDUCCIÓN E INHIBICIÓN DE SISTEMAS DE EXPULSIÓN ACTIVA EN ESCHERICHIA COLI Y SU RELACIÓN CON LA PRODUCCIÓN DE BIOFILM FIS . REF. CP05/00140
PLANES DE ACTUACIÓN FRENTE A UNA PANDEMIA DE GRIPE: ANÁLISIS SISTEMÁTICO DE LOS ACTUALMENTE VIGENTES EN ESPAÑA Y DESARROLLO DE UN EJERCICIO DE SIMULACIÓN PARA EVALUAR LOCALMENTE SU FACTIBILIDAD. FIS . REF. PI070184
CARACTERIZACIÓN, INDUCCIÓN E INHIBICIÓN DE SISTEMAS DE EXPULSIÓN ACTIVA EN ESCHERICHIA COLI Y ACINETOBACTER BAUMANNII FIS . REF. 05/0068

The strategic objective is the study of the inflammatory response in general. The main lines of research are: - Oxidative stress and its relation with diet. - Mechanisms involved in the development of systemic inflammatory processes. - Study of idiopathic pulmonary fibrosis. - Cellular, renal and intestinal hypoxia. - Mechanisms of the protective effect of ischemic preconditioning.

Projects financed:

PAPEL DEL RAS EN EL TRASPLANTE EXPERIMENTAL DE HÍGADO CON INJERTO DE TAMAÑO REDUCIDO CICYT . REF. SAF-0385

Projects financed:

ESTUDIO DE LAS PROPIEDADES INMUNOMODULADORAS DE MIEMBROS LINFOIDES Y NO LINFOIDES DEL GRUPO B DE LA SUPERFAMILIA SRCR (SCAVENGER RECEPTOR CYSTEINE-RICH) MEC . REF. SAF2007-62197
IDENTIFICACIÓN Y CARACTERIZACIÓN DE RECEPTORES LEUCOCITARIOS Y LIGANDOS INTRACELULARES QUE REGULAN LA FUNCIÓN DE LA MOLÉCULA ADAPTADORA 3BP2 EN CÉLULAS HEMATOPOYÉTICAS MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2006-00574

The main objectives o research of the team are: - Physiopathology and prognostic of patients with acute coronary syndrome. - Stratification of the risk of patients with thoracic pain, with negative troponin test and without changes in electrocardiogramme. - Physiopathology of cardiac insufficiency. Study of its molecular and cellular basis. - Mechanisms of control of intimae hyperplasia post vascular injury and regulation of vascular tone in animal models.

Projects financed:

TRATAMIENTO Y EVOLUCIÓN A CORTO PLAZO DE LOS ANCIANOS CON INFARTO AGUDO DE MIOCARDIO INGRESADOS EN HOSPITALES CON DISPONIBILIDAD DE ANGIOPLASTIA PRIMARIA. EL REGISTRO TRIANA (TRATAMIENTO DEL INFARTO AGUDO DE MIOCARDIO EN ANCIANOS). INSTITUTO DE SALUD CARLOS III . REF. PI04/42297
GRADO DE INFLAMACIÓN VASCULAR Y TROMBOGENICIDAD EN PACIENTES NO DIABÉTICOS CON SÍNDROME CORONARIO AGUDO SIN ELEVACIÓN DEL SEGMENTO ST Y ALTERACIÓN EN EL METABOLISMO DE LA GLUCOSA AYUDA DEL FONDO DE INVESTIGACIONES SANITARIAS DE LA SEGURIDAD SOCIAL . REF. FIS 2006/PI050120
FACTORES DE RIESGO, EVOLUCIÓN Y TRATAMIENTO DE LAS ENFERMEDADES CARDIOVASCULARES Y SUS MECANISMOS MOLECULARES Y CELULARES? FONDO INVESTIGACIÓ SANITARIA . REF. 05/0134
CORRECCIÓN DE ENZIMOPATÍAS MEDIANTE LA INTRODUCCIÓN DE PROTEÍNAS LIGADAS A PTD. INSTITUTO DE SALUD CARLOS III. . REF. PI050783
REGENERACIÓN MIOCARDICA MEDIANTE CÉLULAS MADRE MESENQUIMALES EN UN MODEL PORCINO DE INFARTO DE MIOCARDIO: COMPARACIÓN ENTRE LAS VÍAS DE ADMINISTRACIÓN INTRACORONARIA E INTRA MIOCÁRDICA DIRIGIDA POR SISTEMA CARTO. FIS . REF. PI060110
CANALES IÓNICOS Y PROLIFERACIÓN DE LA ÍNTIMA: CARACTERIZACIÓN DEL PAPEL FUNCIONAL DE LOS CANALES IÓNICOS EN EL PROCESO DE MODULACIÓN FENOTÍPICA DE LAS CÉLULAS MUSCULARES LISAS DE LA PARED ARTERIAL?. INSTITUTO DE SALUD CARLOS III. . REF. PI 041139
ANÁLISIS DE LA METODOLOGÍA Y DE LA UTILIDAD CLÍNICA DE LA OPTIMIZACIÓN DE LOS DISPOSITIVOS DE RESINCRONIZACIÓN CARDIACA EN LOS PACIENTES CON INSUFICIENCIA CARDIACA FONDO DE INVESTIGACIONES SANITARIAS, INSTITUTO DE SALUD CARLOS III . REF. PI 05/0118

The team are interested in three research objectives: - Firstly, to continue to develop research projects connected to prevalent pathologies, with a special interest in new therapies in the field of arrhythmia and cardiac stimulation. - Secondly, to develop the study line on channelopathies, expanding research in Brugadas Syndrome to other channelopathies such as long QT Syndrome. - Lastly, we want to initiate a basic research line with animal experimentation to create animal models in order to answer clinical challenges.

Projects financed:

EUROPEAN LIVING DONATION AND PUBLIC HEALTH (EULID) PUBLIC HEALTH EXECUTIVE AGENCY (PHEA) . REF. Agreement Number 2006211
RELACIÓN ENTRE LA FIBRILACIÓN AURICULAR AISLADA Y LA PRÁCTICA DEPORTIVA CRÓNICA. ESTUDIO DE LAS REPERCUSIONES ESTRUCTURALES EN LA AURÍCULA DERIVADAS DEL EJERCICIO CRÓNICO MEDIANTE EL DESARROLLO DE UN MODELO EXPERIMENTAL CON RATAS. FONDO DE INVESTIGACIÓN SANITARIA. MINISTERIO DE SANIDAD Y CONSUMO. . REF. FIS PI050210
"BENEFICIO DE LA RESINCRONIZACIÓN EN PACIENTES CON QRS ESTRECHO Y PAPEL PRONÓSTICO DE LAS METALOPROTEASAS Y DEL PROCOLÁGENO TIPO I (PIP) EN LA RESINCRONIZACIÓN CARDIACA" FONDO DE INVESTIGACIÓN SANITARIA . REF. PI050105

To get a better understanding of the physiopathology and treatment of kidney, urinary apparatus and masculine reproductive apparatus diseases and of medical complications stemming from the substitutive kidney treatment with dialysis of transplant. Our main aims are the study of immunosupression in pharmacokinetics and pharmacodynamic aspects. Furthermore, with the incorporation of a group specialised in transplant immunology, our objectives are also to achieve a better tolerance to allograft and xenograft, and to reduce the need for immunodepressants. Another
challenge is to go deeper into the knowledge related to the achieved degree of immunodepression in patients with respect to their needs: pharmacokinetics/ pharmacodynamics rate.

Projects financed:

DETERMINACIÓN DE LA DISEMINACIÓN LINFÁTICA DEL CARCINOMA UROTELIAL DE VEJIGA MEDIANTE MARCADORES MOLECULARES Y UTILIZACIÓN DE ESTOS PARA PRONOSTICAR LA EVOLUCIÓN CLÍNICA DE LA ENFERMEDAD FIS . REF. PI070040
ESTUDI DE LA DISFUNCION ENDOTELIAL EN EL TRASPLANTE RENAL. PAPEL DEL TRATAMIENTO INMUNOSUPRESOR MINISTERIO DE SANIDAD Y CONSUMO . REF. 01/1513
ENFERMEDAD CARDIOVASCULAR EN LA UREMIA: ANALISIS DE LA PREVALENCIA Y RELEVANCIA DE LOS FACTORES DE RIESGO CARDIOVASCULAR FISS . REF. 03/0791
ESTUDIO DEL POLIMORFISMO DE MOLECULAS RELACIONADAS CON GENES DE CLASE I DEL MHC(MIC) INDUCIBLES POR ESTRES EN EL ENDOTELIO Y SU PARTICIPACIÓN EN EL RECHAZO DE ALOINJERTOS FONDOS DE INVESTIGACIONES SANITARIAS . REF. 03/0385
ANÁLISIS PROTEÓMICO DE LA ORINA EN LA AFECCIÓN RENAL ASOCIADA A DIABETES TIPO II. EFECTO DEL BLOQUEO DEL SISTEMA RENINA ANGIOTENSINA. ISCIII . REF. FIS P05/0015

The main objective is to increase knowledge and understanding of epidemiology, pathogenesis, diagnosis, treatment and prevention of dyslipidemia. Our current research lines are: - Characterisation of genetic dyslipidemia. - Detection of pre-clinical atherosclerosis. - Mechanisms and consequences of silent lesion of target organs in hypertension. - Interaction of environmental determinants in the cardiovascular disease such as salt consumption and the phenomenon of salt sensitivity. - Candidate genes in hypertension and their complications. - Study of cardiovascular functionality of food. - Study of intestinal cholesterol absorption, and assessment of mild cognitive impairment in dyslipidemia.

Projects financed:

INTEGRATED GENOMICS, CLINICAL RESEARCH AND CARE IN HYERTENSION (INGENIOUS HYPERCARE): SUBPROJECT B1 GENETIC AND GENOMICS OF HYPERTENSION AND STROKE UE . REF. JRP-B1
MECANISMOS FISIOPATOLÓGICOS ASOCIADOS A LA DISFUNCIÓN ENDOTELIAL EN LA HTA ESENCIAL EN RELACIÓN A LA SENSIBILIDAD A LA SAL FONDO DE INVESTIGACIÓN SANITARIA . REF. FIS 00/0435

The general objectives of this group are the study of key biophysical mechanisms of the respiratory function and development of biomedical image and signal processing models and methods. This group is part of the recently created Catalan Bioengineering Reference Centre. The work is based in a multidisciplinary approach and the integration of basic and clinical research. In parallel to the scientific objectives, our group promotes the transference of technologic advances stemming from research to industry.

Projects financed:

RECONSTRUCCIÓN TRIDIMENSIONAL DE ALTA RESOLUCIÓN EN CÁMARAS PET DE ANIMALES PEQUEÑOS. FIS . REF. PI047017

The objectives of research of this group are: - Study of aetiopathogenesis, diagnosis, treatment and prevention of community and hospital respiratory infections in humans and experimental bodies in immunodepression and in pulmonary tuberculosis. - Study of epidemiology and treatments of severe respiratory insufficiency, particularly the acute respiratory distress syndrome (ARDS) and its relation to respiratory infections and sepsis. - Study of invasive and non-invasive mechanic ventilation in humans and in animal model. Physiopathological aspects, clinical aspects, cost-effectiveness. - Study of the Chronic Obstructive Pulmonary Disease (COPD) in exacerbation. Involvement of pulmonary infections. - Study of pharmacokinetics and pharmacodynamics of antibiotics and other drugs in respiratory patients and in porcine animal model. - Study of the respiratory infection in Mozambique in collaboration with the Assessment, Support and Prevention Unit in IDIBAPS-Hospital Clínic. - Study of microorganism resistances to antituberculosis drugs and antibiotics. - Study of tuberculosis transmission.

Projects financed:

EFICACIA DE LOS GLUCOCORTICOIDES EN LA NEUMONÍA ASOCIADA A LA VENTILACIÓN MECÁNICA. ESTUDIO CLÍNICO ALEATORIZADO FIS . REF. EC07/90390
MODELO MURINO CRÓNICO DE APNEA DURANTE EL SUEÑO. REPERCUSIONES BIOLÓGICAS E HISTOLÓGICAS ESPECÍFICAMENTE SOBRE SISTEMA CARDIOVASCULAR. APLICACIÓN MARCADORES BIOLÓGICOS EN HUMANOS CON APNEAS I+D . REF. SAF2004-00684
EFICACIA DEL TRATAMIENTO CON LINEZOLID COMPARADO CON VANCOMICINA EN LA NEUMONÍA ASOCIADA A LA VENTILACIÓN MECÁNICA POR STAPHYLOCOCCUS AUREUS METICILIN-RESISTENTE. ESTUDIO EN UN MODELO PORCINO. FONDO INVESTIGACIÓN SANITARIA . REF. fondo Investigación Sanitaria
MODELO ANIMAL DE NEUMONÍA ASOCIADA A LA VENTILACIÓN MECÁNICA (NAVM). ESTUDIO DE LA RESPUESTA INFLAMATORIA ASOCIADA Y SU MODULACIÓN POR GLUCOCORTICOIDES ISCIII . REF. PI050136

The objectives of the group are: - Study of the molecular and cellular basis of the chronic respiratory diseases, with special emphasis in the disorders of pulmonary circulation and in extrapulmonary manifestations. - Study of the physiopathological and pathogenic mechanisms related to acute and chronic respiratory insufficiency and to respiratory sleep disorders, and hepatic and pulmonary disorders. - Development of models of artificial and bioartificial lung for intra- and extrahospital support for patients with respiratory insufficiency. - Study of determinant factors of clinical evolution and utilisation of health resources in chronic respiratory diseases.

Projects financed:

PULMONARY HIPERTENSIÓN: FUNCTIONAL GENOMICS AND THERAPY OF LUNG VASCULAR REMODELLING (PULMOTENSION) UNIÓ EUROPEA (6TH FWP) . REF. SLMM-CT-2005-018725
GENERATION OF TISSUEENGINEERED TRACHEA MINISTERIO DE SANIDAD (FIS) . REF. PI050987
BIOBRIDGE COMISIÓN EUROPEA . REF. LSHG-CT-2006-037939
INTERCAMBIO PULMONAR GASEOSO, EJERCICIO FÍSICO, MANITOL Y ANTICOLINÉRGICOS EN PACIENTES CON ASMA Y EPOC. ISCIII . REF. PI05208
CARE-MAN UE . REF. 2006-017333

The main goal of the team is to conduct research on mechanisms regulating inflammatory response and remodelling in bronchial asthma, rhinosinusitis and interstitial pulmonary diseases. The lines of research are: - Molecular and cellular basis of the inflammatory response in asthma, rhinosinusitis and pulmonary interstitial diseases. - Role of metabolites of the arachidonic acid (prostaglandins and leukotrienes) in the aetiopathogenesis of asthma, chronic rhinosinusitis and pulmonary interstitial diseases. - Study of mechanisms regulating the response to treatment with glucocorticoids in respiratory inflammatory diseases. - Study of mechanisms involved in severe asthma. - New therapeutic modalities (endothelin, proteasome and COX-2 inhibitors, E2 prostaglandin 3 receptor agonists) in asthma, rhinosinusitis and interstitial pulmonary diseases, using animal models of asthma and pulmonary fibrosis.

Projects financed:

ESTUDIO DE LOS MECANISMOS DE LA REGULACIÓN IN VIVO E IN VITRO DE LA EXPRESIÓN DE MUCINAS EN LA POLIPOSIS NASOSINUSAL SIN O CON ASMA. PAPEL DE LES CINASAS MAP Y DEL NFKB Y SU REGULACIÓN POR CORTICOIDES FONDO DE INVESTIGACIÓN SANITARIA (FIS), INSTITUTO DE SALUD CARLOS III. . REF. PI050069
ESTUDIO DE AL RELACIÓN ENTRE LA INTOLERANCIA A LOS ANTIINFLAMATORIOS NO ESTEROIDEOS Y LA PRODUCCIÓN DE PROSTAGLANDINA E2 CON AL GRAVEDAD DEL ASMA. FONDO DE INVESTIGADORES SANITARIAS . REF. PI050108

The research objectives of the team are: - To get a better understanding on the causes and mechanisms involved in sterility or in gestational loss. - To implement treatment forms adapted to new discoveries and to analyse success and failure factors in the use of assisted fecundation techniques applied to patients with reproductive problems. - To get better knowledge of climaterium and to assess the efficiency of several therapeutic forms in the most frequent pathologies in postmenopausal women.

Projects financed:

INVESTIGACIÓN DEL POTENCIAL FIBRINOLÍTICO GLOBAL DEL PLASMA COMO MECANISMO PATOGÉNICO EN LA PATOLOGÍA GESTACIONAL PRECOZ AVANZADA. RELACIÓN CON LOS ANTICUERPOS ANTIFOSFOLIPÍDICOS FIS . REF. PI050026
INVESTIGACIÓN DE NUEVOS MECANISMOS PROTROMBÓTICOS EN LA PATOGENIA DEL SÍNDROME ANTIFOSFOLIPÍDICO (SAF) OBSTÉTRICO MINISTERIO DE SANIDAD Y CONSUMO . REF. FIS-PI-041114
INVESTIGACIÓN DEL POTENCIAL FIBRINOLÍTICO GLOBAL DEL PLASMA COMO MECANISMO PATOGÉNICO EN LA PATOLOGÍA GESTACIONAL PRECOZ AVANZADA. RELACIÓN CON LOS ANTICUERPOS ANTIFOSFOLIPÍDICOS FIS . REF. 05/0026
INVESTIGACIÓN DE NUEVOS MECANISMOS PROTROMBÓTICOS EN LA PATOGENIA DEL SÍNDROME ANTIFOSFOLIPÍDICO (SAF) OBSTÉTRICO MINISTERIO DE SANIDAD Y CONSUMO . REF. PI-041114
MORTALIDAD MATERNA EN EL ÁFRICA SUBSAHARIANA: CONTRIBUCIÓN DE LA INFECCIÓN POR EL VIRUS DE LA INMUNODEFICIENCIA HUMANA Y LA MALARIA FIS . REF. PI060207
INVESTIGACIÓN DEL POTENCIAL FIBRINOLÍTICO GLOBAL DEL PLASMA Y SU REGULACIÓN COMO MECANISMO PATOGÉNICO EN LA PATOLOGIA GESTACIONAL PRECOZ Y AVANZADA. RELACIÓN CON LOS ANTICUERPOS ANTIFOSFOLIPÍDICOS. MINISTERIO DE SANIDAD Y CONSUMO . REF. FIS-PI-050026

Our main strategic objective, and most of our resources, are devoted to the development of infrastructure and stable multidiscipline research lines for the prediction and prevention of neurological damage caused by foetal hypoxia and/or inflammation. These research lines have the collaboration of Foetal Medicine, Neonatology, Neuroimaging, Neuropaediatry and Molecular Biology groups. Other objectives of our group are the development and consolidation of lines existing in other fields such as perinatal infections, with an especial interest in HIV and neonatal infection, therapy and foetal surgery, screening strategies and prediction of foetal and mother pathologies in large populations, and prematureness.

Projects financed:

CRIBADO PRENATAL DEL SÍNDROME DE DOWN MEDIANTE TEST DE CONTINGENCIA EN EL PRIMER TRIMESTRE. ESTUDIO MULTICÉNTRICO DE APLICACIÓN DEL TEST COMBINADO SEGUIDO DEL ESTUDIO SELECTIVO DE MARCADORES ECOGRÁFICOS SECUNDARIOS INSTITUTO DE SALUD CARLOS III. SUBDIRECCIÓN GENERAL DE EVALUACIÓN Y FOMENTO DE LA INVESTIGACIÓN. MIN . REF. 06/0151
BASES CEREBRALES ESTRUCTURALES Y FUNCIONALES DE LOS DÉFICIT NEUROPSICOLÓGICOS ASOCIADOS A LA PREMATURIDAD AYUDA DE INVESTIGACIÓN I+D (MINISTERIO DE CIENCIA Y TECNOLOGÍA . REF. SAF05_007340
VALORACIÓN DEL IMPACTO DE UN PROGRAMA DE INTERVENCIÓN PRECOZ BASADO EN LA AUTOIDENTIFICACIÓN DE LA VAGINOSIS BACTERIANA POR LA PROPIA GESTANTE POR MEDIO DE LA MEDICIÓN SEMANAL DEL PH VAGINAL FIS . REF. PI060559
MODOS DE VENTILACIÓN ASISTIDA CON VOLUMEN GARANTIZADO ¿PUEDEN REDUCIR LA INCIDENCIA DE DISPLASIA BRONCOPULMONAR EN EL PREMATURO EXTREMO? FIS . REF. TI030209
ÓXIDO NÍTRICO EXHALADO TOTAL Y NITRITOS-NITRATOS E IL-8 ENDOTRAQUEALES EN EL RECIÉN NACIDO PREMATURO VENTILADO. RELACIÓN CON LA CORIOAMNIONITIS Y LA DISPLASIA BRONCOPULMONAR. FISS . REF. PI060052
A MULTIDISCIPLINARY RESEARCH TRAINING PROGRAMME IN FETAL MEDICINE AND HEALTH EUROPEAN COMMISSION VI FRAMEWORK PROGRAMME . REF. FETAL-MED 19707
CONTRIBUCIÓN DE LA VALORACIÓN HEMODINÁMICA DEL DUCTUS VENOSO EN LA DETECCIÓN PRENATAL DEL SÍNDROME DE DOWN Y OTROS DEFECTOS CONGÉNITOS EN POBLACIÓN GENERAL DE GESTANTES MINISTERIO DE SANIDAD Y CONSUMO . REF. FIS 02/0627
PROGESTERONA VAGINAL COMO TRATAMIENTO DE MANTENIMIENTO EN GESTANTES CON AMENAZA DE PARTO PREMATURO (PROMESA)? INSTITUTO DE SALUD CARLOS III . REF. EC07/90023

Projects financed:

OPTIMIZACIÓN DE ENTRENAMIENTOS AERÓBICOS Y ANAERÓBICOS. ANÁLISIS PROTEÓMICO, TRANSCRIPCIONAL Y DEL METABOLISMO ENERGÉTICO DEL MÚSCULO DIRECCIÓN GENERAL DE INVESTIGACIÓN CIENTÍFICA Y TÉCNICA . MEC . REF. BFU2005-08506-C02-01/BFI

Our main aim is to conduct first-line research on metabolic bone pathology, with a particular emphasis on clinical research, biochemical markers of bone sparing, mediators of osteoclastogenesis and cultures of bone cells.

Projects financed:

ESTUDIO DEL EFECTO BIFASICO DE LA HORMONA PARATIROIDEA PTH SOBRE OSTEOBLASTOS HUMANOS PRIMARIOS EN CULTIVO. ACCIÓN SOBRE EL SISTEMA OPG/RANKL Y LOS MARCADORES DE DIFERENCIACIÓN OSTEOBLÁSTICA RUNX2/CBFA1, OSTEOCALCINA Y PROCOLAGENO TIPO I FIS . REF. PI050044

The objectives of the research team is the investigation on the epidemiological, pathogenic,diagnostic and therapeutic aspects of infections by hepatitis virus in immunocompetent and liver-transplanted patients. The main lines of research are: - Diagnostic and therapeutic aspects in chronic hepatitis C. - Natural history of hepatitis C recurrency and prevention of relapse in liver-transplanted patients. - Genetic evolution of hepatitis C virus. - Study on the compartmenting of hepatitis C virus: virus replication in extrahepatic compartments. - Natural history of chronic hepatitis B: influence of viral genotypes.

Projects financed:

ESTUDIO DE LA PREVALENCIA, LA CLÍNICA Y LOS FACTORES EPIDEMIOLÓGICOS ASOCIADOS A LA INFECCIÓN POR METAPNEUMOVIRUS HUMANO EN POBLACIÓN INFANTIL Y ADULTA FIS . REF. PI050063
ESTUDIO DE LA COMPARTIMENTALIZACIÓN DEL VIRUS DE LA HEPATITIS C (VHC) Y SU RELACIÓN CON LA RECIDIVA DE LA INFECCIÓN TRAS EL TRATAMIENTO ANTIVIRAL Y EL TRASPLANTE HEPÁTICO.. INSITUTO DE SALUD CARLOS III . REF. FIS 05-0258
HEPATITIS CRÓNICA B CON ANTI-HBE POSITIVO: ANÁLISIS DE LA RELACIÓN ENTRE LA HETEROGENEIDAD DEL VIRUS B Y LA EVOLUCIÓN DE LA ENFERMEDAD FIS . REF. 02/0678

The objectives and main lines of researhc are: - Molecular determinants of liver inflammation. Role of Kupffer cells. - Eicosanoids and renal function in cirrhosis. - Physiopathology and treatment of hepatorenal syndrome and renal insufficiency associated to bacterial infections. - Assessment of cirrhotic myocardiopathy. - Relationship between hepatic encephalopathy and changes of renal function in cirrhosis. - Pathogenicity, clinical consequences and treatment of hyponatraemia. - Assessment of several methods of brain magnetic resonance in cirrhotic patients. Relationship with hepatic encephalopathy. - Role of endogenous cannabinoids in the physiopathology of arterial vasodilation. - Application of Genomics and gene therapy in liver dysfunction treatment. - Angiogenesis, oedema and vascular remodelling in hepatic cirrhosis. - Pathogenesis of hepatic fibrosis: cellular basis and identification of new therapeutic strategies. - Physiopathology and treatment of arterial vasodilation. - Physiopathology and treatment of ascites.

Projects financed:

FIBROSIS HEPÁTICA SECUNDARIA A ESTEATOHEPATITIS NO ALCOHÓLICA: DIAGNÓSTICO NO INVASIVO. BASES PATOGÉNICAS Y NUEVAS ESTRATEGIAS TERAPÉUTICAS FONDO DE INVESTIGACIÓN SANITARIA . REF. FIS PI050567
INVESTIGACION DE LOS MECANISMOS CELULARES Y MOLECULARES RESPONSABLES DE LA FIBROSIS QUISTICA HEPATICA INDUCIDA POR EL VIRUS DE LA HEPATITIS C PLAN NACIONAL I+D . REF. SAF2005/06245
PARTICIPACIÓN DE LOS MEDIADORES LIPÍDICOS DERIVADOS DEL ÁCIDO ARAQUIDÓNICO EN EL DESARROLLO Y PROGRESIÓN DE LA INFLAMACIÓN Y ESTEATOSIS HEPÁTICA. EFECTO DE LOS ACIDOS GRASOS POLIINSATURADOS OMEGA-3 MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF 06/03191
COMPLICACIONES DE LA CIRROSIS EN PACIENTES EN CANDIDATOS A TRASPLANTE HEPÁTICO. DISEÑO DE NUEVAS ESTRATEGIAS PARA LA REDUCCIÓN DE LA MORTALIDAD EN LISTA DE ESPERA DE TRASPLANTE HEPÁTICO FONDO DE INVESTIGACIÓN SANITARIA . REF. PI050246
EFICACIA DE LA ADMINISTRACIÓN DE ALBÚMINA ENDOVENOSA SOBRE LA SUPERVIVENCIA Y PREVENCIÓN DEL DESARROLLO DE LA INSUFICIENCIA RENAL EN PACIENTES CON CIRROSIS Y SEPSIS. ESTUDIO ALEATORIZADO Y CONTROLADO FIS . REF. 05/02/73
FIBROSIS, DISFUNCIÓN HEMODINÁMICA Y RENAL Y PREVENCIÓN DEL RECHAZO EN LA ENFERMEDAD HEPÁTICA. EVALUACIÓN DE NUEVAS ESTRATEGIAS TERAPEUTICAS EN MODELOS EXPERIMENTALES DE CIRROSIS Y TRANSPLANTE DE HÍGADO DIRECCIÓN GENERAL DE INVESTIGACIÓN CIENTÍFICA . REF. SAF2006-07053

The aim of the group is to study the clinical and therapeutic aspects of hepatic cancer and other basic aspects. Our research activity is always concerned in the mechanisms regulating the progression of this disease. At a clinical level, work is carried out in the definition of optimal criteria for prescribing radical treatment (surgical resection, transplant from dead donor or living donor, percutaneous approach with alcohol injection or thermal ablation) to achieve the maximal efficiency in terms of both survival and associated morbidity.

Projects financed:

UTILIDAD DE LA RESONANCIA MAGNÉTICA DE 3T CON ESPECTROSCOPIA EN EL DIAGNÓSTICO Y CARACTERIZACIÓN DEL CARCINOMA HEPATOCELULAR? FONDO DE INVESTIGACIÓN SANITARIO . REF. 92/5515
PERFIL DE EXPRESIÓN GÉNICA EN LESIONES PRENEOPLÁSICAS Y EN EL CARCINOMA HEPATOCELULAR INICIAL, EN LA CIRROSIS POR EL VIRUS DE LA HEPATITIS C. APLICACIÓN EN LA DETECCIÓN PRECOZ Y EN EL DIAGNÓSTICO INSTITUTO DE SALUD CARLOS III . REF. PI050150
ESTUDIO DE FLUJO Y CONSUMO DE OXIGENO INTRAHEPATICOS COMO MARCADORES DE LESION ISQUEMICA HEPATICA DURANTE LA HEPATECTOMIA EN EL DONANTE VIO FUNDACIO LA MARATO . REF.
INTEGRATIVE GENOMIC ANALYSIS IN HEPATOCELLULAR CARCINOMA NATIONAL INSTITUTE OF HEALTH-USA (NIDDK). . REF. IR01DK076986-01

The objective of research of this groups is to increase knowledge and understanding of mechanisms responsible for portal hypertension, the main complication arising from the hepatic disease, and to develop new treatments for this syndrome. The main lines of research are: - Factors regulating hepatic microcirculation in normal conditions and in cirrhosis, through studies of perfusion in isolated liver. - Intrahepatic endothelial dysfunction in cirrhosis: role of oxidative stress: Role of Kupffer cells. - Posttranscriptional regulation of endothelial nitric oxide synthase (eNOS) activity by statins. Relevance in treatment of portal hypertension. - Regulation of development of collateral circulation and hyperdynamic circulation by angiogenic factors in portal hypertension models. - Bacterial DNA, endotoxemia and haemodynamic disorders in cirrhosis. - Non-invasive study of the hepatic circulation through reperfusion Doppler echography. - Clinical studies of randomised distribution of new treatments for portal hypertension. - New diagnostic and therapeutic methods for the hepatic vascular disease.

Projects financed:

DISFUNCIÓN ENDOTELIAL Y ACTIVIDAD ENOS EN LA CIRROSIS. MECANISMO, SIGNIFICACIÓN Y NUEVAS APLICACIONES TERAPÉUTICAS ISCIII . REF. PI06/0623
HISTORIA NATURAL Y FACTORES PREDICTIVOS DEL FRACASO HEPÁTICO AGUDO SOBRE HEPATOPATIA CRÓNICA (ACUTE-ON-CHRONIC). IMPLICACIONES PARA EL DESARROLLO DE ALTERNATIVAS TERAPÉUTICAS Y VALORACIÓN DE UNA ESTRATEGIA DE PREVENCIÓN EN PACIENTES DE ALTO RIESGO FONDO DE INVESTIGACIONES SANITARIAS DE LA SEGURIDAD SOCIAL . REF. PI 04/1031
MECANISMOS MOLECULARES DE LA DISFUNCIÓN ENDOTELIAL INTRAHEPATICA EN LA CIRROSIS. NUEVAS DIANAS TERAPÉUTICAS DE LA HIPERTENSIÓN PORTAL ISCIII . REF. SAF2007-61298

The main objective of the team research is to increase knowledge and understanding of molecular basis of intestinal inflammation in order to identify new therapeutic targets for the intestinal inflammatory disease and to identify the mechanisms involved in the development and progression of pre-malignant and malignant lesions of digestive origin. The lines of investigation in the area of inflammation include: - Identification of the genetic factors determining the susceptibility or the phenotype of inflammatory bowel disease. - Evaluation of the implication of the NOD2 and TLR mutations associated with Crohn's disease in relation to the response of dendritic cells. - The study of the mechanisms of fibrogeneisis in human Crohn's disease and evaluation of the efficacy of different treatment strategies in experimental models. - Development and evaluation of new drugs with adhesion molecule inhibitory capacity (peptides and peptidominetics). - Clinical and molecular characterisation of the forms of hereditary and familial colorectal cancer and strategies for their identification. - Characterisation of the molecular mechanisms involved in the development and progression of colorectal cancer. - Development and evaluation of screening and surveillance strategies for colorectal cancer. - Evaluation of the new therapeutic approaches in pancreas and gastric cancer in experimental and human models. - Evaluation of new endoscopic strategies to identify premalignant lesions and initial forms of cancer. - Technological innovation and development in digestive endoscopy.

Projects financed:

POLIMORFISMOS EN GENES CANDIDATOS INVOLUCRADOS EN CÁNCER COLORRECTAL FAMILIAR: CARACTERIZACIÓN DE COMPONENTES GENÉTICOS COMUNES Y DE BAJA PENETRANCIA DE SUSCEPTIBILIDAD PARA EL DESARROLLO Y PREDICCIÓN DE LA RESPUESTA AL TRATAMIENTO DEL CÁNCER COLORRECTAL. FONDO DE INVESTIGACIÓN SANITARIA . REF. FIS05/0071
ANÁLISIS DE EXPRESIÓN GÉNICA DELA ENFERMEDAD INFLAMATORIA: RELACÓN CON EL FENOTIPO, PROGRESIÓN DE LA ENFERMEDAD Y RESPUESTA AL TRATAMIENTO. FIS . REF. SAF2006-03074
ANALISIS DE EXPRESION GENICA EN LA ENFERMEDAD INFLAMATORIA INTESTINAL: RELACION CON EL FENOTIPO, PROGRESION DE LA ENFERMEDAD Y RESPUESTA AL TRATAMIENTO. MINISTERIO DE EDUCACIÓN Y CIENCIA. PROGRAMA I+D . REF. SAF 2006-03074
PAPEL DE LAS INTEGRINAS ALFA4 EN LA GÉNESIS DE LA ENFERMEDAD INFLAMATORIA INTESTINAL Y VALOR TERAPÉUTICO DE SU BLOQUEO MEDIANTE PEQUEÑAS MOLÉCULAS. MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2005-03755
DEVELOPEMENT OF A NEW DNA ARRAY-BASED DIAGNOSTIC SYSTEM (IBDCHIP) TO PREDICT CLINICAL COURSE, DEVELOPEMENT OF COMPLICATIONS, AND RESPONSE TO THERAPY IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE. EUROPEAN COMMISSION - 6FT . REF. LSHB-CH-2006-037319

The objective is to increase knowledge in several aspects of clinical hepatology. Main lines of research: bacterial infection; cholestasis, severe acute hepatic insufficiency; autoimmune chronic hepatitis; and porphyrins.

Projects financed:

TRATAMIENTO DEL PRURITO REFRACTARIO DE LA COLESTASIS MEDIANTE DIÁLISIS CON ALBÚMINA: ESTUDIOS MOLECULARES MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2005-03649
EVOLUCIÓN DE LA RECIDIVA DE LA INFECCIÓN POR VIRUS DE LA HEPATITIS C EN EL TRASPLANTE HEPÁTICO DE DONANTE VIVO. COMPARACIÓN CON EL TRASPLANTE CONVENCIONAL. PAPEL DE LAS LIPOPROTEÍNAS EN LA CINÉTICA Y EN LA INFECTIVIDAD DEL VIRUS DE LA HEPATITIS C. PI05023 INSTITUTO DE SALUD CARLOS III (FISS) . REF. PI050230
TRATAMIENTO DEL PRURITO REFRACTARIO DE LA COLESTASIS MEDIANTE DIÁLISIS CON ALBÚMINA: ESTUDIOS MOLECULARES MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2005-03649

The objective of research of the group is the determination of intracellular signalling and role of mitochondrion in the cellular susceptibility in processes of inflammation, hypoxia, stress, and the regulating role of cholesterol and sphingolipids, as well as to study the role of mitochondrial GSH in the regulation of NF-kB and HIF-1a through the modulation of respiratory chain free radicals generation. The main lines of research are: Regulation of cellular death by oxidative stress and sphingolipids. - Gene expression and activation of NF-kB and HIF-1a in hypoxia. - Hepatocellular susceptibility in TNF, Fas and hypoxia. - Cholesterol homeostasis regulation in non-alcoholic steatohepatitis. - Chemosensitivity and mitochondrial cholesterol. - Regulation of the mitochondrial transit of cholesterol. - Cholesterol and sphingolipids in the Niemann Pick C disease.

Projects financed:

HOMEOSTASIS DEL COLESTEROL LIBRE HEPÁTICO EN LA ESTEATOHEPATITIS ALCOHÓLICA. IMPLICACIONES FISIOPATOLÓGICAS Y TERAPÉUTICAS DE SU REGULACIÓN. INSTITUTO DE SALUD CARLOS III (FIS) . REF. PI060085
MECANISMOS MOLECULARES DE LA DISFUNCIÓN ENDOTELIAL INTRAHEPÁTICA EN LA CIRROSIS. NUEVAS DIANAS TERAPEUTICAS DE LA HIPERTENSION PORTAL. MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. U-PN-61298
ESFINGOLÍPIDOS EN CÁNCER HEPÁTICO Y COLORECTAL: REGULACIÓN E IMPLICACIONES TERAPÉUTICAS. MINISTERIO DE SANIDAD Y CONSUMO / INSTITUTO DE SALUD CARLOS III . REF. FIS 06/0395

The objective of the group is to conduct research on clinical, physiopathological and therapeutic aspects of hepatic transplantation. The lines research of the group are: - Hepatic lesion of preservation, with special emphasis in the ischemia-reperfusion lesion. - Immunosupression, with special emphasis in pharmacokinetics and pharmacodynamics of immunosuppressive products, and tolerance.

Projects financed:

EUROPEAN QUALITY SYSTEM FOR TISSUE BANKING COMISSIÓ EUROPEA; SANCO . REF. Proposal 2003209
MONITORIZACIÓN INMUNOLÓGICA EN EL TRASPLANTE HEPÁTICO. MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. LSHG-CT-2006-037939

The main objective of research is to develop projects permitting to improve the diary clinical assistance in patients with pancreatic diseases, digestive haemorrhage and disorders of the intestinal motility.

Projects financed:

ANALISIS DE EXPRESION GENICA EN LA ENFERMEDAD INFLAMATORIA INTESTINAL: RELACION CON EL FENOTIPO, PROGRESION DE LA ENFERMEDAD Y RESPUESTA AL TRATAMIENTO. MINISTERIO DE EDUCACIÓN Y CIENCIA. PROGRAMA I+D . REF. SAF2006-03074
PRIMOVAX. ESTUDIO COMPARATIVO EN FASE III ENTRE LA COMBINACIÓN SECUENCIAL DE GV 1001 I GEMCITABINA Y LA MONOTERAPIA DE GEMCITABINA EN CÁNCER DE PÁNCREAS NO RESECABLE AVANZADO ORION CLINICAL SERVICES LTD . REF. 38-001/LSW
SOBREXPRESIÓN D HTERT Y TERT, HIPERACTIVIDAD TELOMERASA Y ACORTAMIENTO DE TELOMEROS COMO FACTOR DE RIESGO DE TRANSFORMACIÓN NEOPLÁSICA EN PACIENTES CON ENFERMEDAD INFLAMATORIA INTESTINAL MINISTERIO DE CIENCIA Y TECNOLOGIA. PLAN NACIONAL I+D+I . REF. SAF 2004-07190
ULTRASONOGRAFÍA ENDOSCÓPICA CON O SIN PUNCIÓN ASPIRATIVA, TOMOGRAFÍA COMPUTARIZADA MULTIDETECTOR Y RESONANCIA MAGNÉTICA EN EL DIAGNÓSTICO DE EXTENSIÓN LOCORREGIONAL DEL CÁNCER DE RECTO. ESTUDIO PROSPECTIVO Y COMPARATIVO INSTITUTO DE SALUD CARLOS III (EVALUACIÓN DE TECNOLOGÍAS SANITARIAS) . REF. PI 06/90464

The main research objectives of the team are: - To investigate the molecular determinants of the beta cell potentially involved in aetiopathogenesis of diabetes. - To investigate signals regulating cellular plasticity in diabetes and obesity.

Projects financed:

DIANAS MOLECULARES INDUCIDAS POR TUNGSTATO EN LA OBESIDAD MINISTERIO DE EDUCACION Y CIENCIA . REF. SAF2006-07382
EFECTOS DEL BY-PASS GASTRICO SOBRE LA PRESION ARERIAL Y LA DISFUNCION ENDOTELIAL EN PERSONAS CON OBESIDAD GRAVE FIS . REF. PI070124

The main research objectives of the team are: - Smoking as a contributory factor to the development of diabetic nephropathy. - Application of computerised techniques and continuous measuring over time for the study of the involvement of early alterations in the vegetative system and blood pressure in the development of diabetic nephropathy. - Study of bone metabolism and alterations in articular mobility in Type 1 diabetes. - Prognostic factors in thyroid cancer. - Study of thyroid volume in different situations, mainly controls and Graves-Basedow disease. - Study of insulin resistance, leptin and tumour necrosis factor in different diseases, mainly in morbid obesity before and after bariatric surgery and in short bowel syndrome. - Study of vascular dysfunction in Type 2 diabetes mellitus and their family members.- Study of vascular dysfunction in growth hormone deficiency.

Projects financed:

DETERMINANTES MOLECULARES DEL METABOLISMO Y LA NUTRICIÓN. BIOCOMUNICACIÓN HORMONAL. NUEVAS ESTRATEGIAS TERAPÉUTICAS FIS DEL INSTITUTO CARLOS III . REF. Red de Centros (CO3/08)
NEOGENESIS DE ISLOTES DE LANGERHANS A PARTIR DE CÉLULAS TRONCALES DEL PÁNCREAS ADULTO INSTITUTO DE SALUD CARLOS III . REF. 06/0891
DETERMINANTES MOLECULARES DEL METABOLISMO Y LA NUTRICION. BIOCOMUNICACION HORMONAL. NUEVAS ESTRATEGIAS TERAPEUTICAS. FIS . REF. CO3/08

The aim of the group is to study cerebral ischemic pathology from both clinical and basic research points of view, with a special emphasis on inflammation and neuroprotection, as well as to identify histopathological, biochemical and molecular correlates of changes detected by neuroimaging. The lines of research: - Disorders of the immune system related to stroke and risk of infection. - Beneficial effect of antioxidative agent in ischemic stroke. - Inflammation and neurological impairment in the ischemic cerebral vascular accident (CVA). - Genetics of ischemic stroke and haemorrhagic stroke Prevention of infection in stroke patients. CVA polymorphisms and subtypes. IL-6 polymorphisms. - Design of phase III studies in generic drugs with antiinflammation or antioxidant properties.

Projects financed:

MUERTE CELULAR PROGRAMADA EN LA ISQUEMIA CEREBRAL: IMPLICACIÓN DEL ESTRÉS DEL RETÍCULO ENDOPLASMICO . MINISTERIO DE SANIDAD . REF. FISss PI050271
PAPEL DE LA HEXOQUINASA EN LA REGULACIÓN DE LA VÍA MITOCONDRIAL DE MUERTE CELULAR PROGRAMADA EN NEURONAS SOMETIDAS A ISQUEMIA. . PLAN NACIONAL DE BIOMEDICINA (CICYT) . REF. SAF2005-05793-C02-02

To have a better understanding of physiopathological mechanisms of psychiatric and neurological diseases, as well as neurotoxicity and ageing processes in the CNS. Our aim is to identify new cellular and functional targets and to propose new therapies. The main lines of research are: - Study on the glial transcription factors as possible therapeutic targets in the treatment of the neurodegenerative disease. - Role of glia in neuroprotection and in neuronal death. Study of how the induction of the glial activation can modify neuronal survival and how glial cells are activated according to the induced neuronal death pattern. - Study on cytotoxicity, oxidative stress, synaptic functions and proteomics to determinate altered targets in toxicity and ageing processes of CNS. Strategies of neuroprotection. - Control of neuronal proliferation. - Study on the neuronal circuitry responsible for the physiopathology and treatment of depression and schizophrenia; focusing in prefrontal cortex. - Study on neurotransmission and its anatomic, cellular, and molecular basis involved in neurodegenerative and psychiatric diseases, in order to identify and to characterize new sites of therapeutic action.

Projects financed:

ALTERACIONES DE LAS CONEXIONES DE LA CORTEZA PREFRONTAL EN EL MODELO DE ESQUIZOFRENIA DE ANTAGONISMO NMDA. SITIO DE ACCIÓN Y MECANISMO DE LOS FÁRMACOS ANTIPSICÓTICOS. FIS/ISCIII . REF. PI07111
PAPEL DE LA CORTEZA PREFRONTAL EN LA FISIOPATOLOGÍA DE LA ESQUIZOFRENIA Y ACCIÓN TERAPÉUTICA DE LOS FÁRMACOS ANTIPSICÓTICOS MEC . REF. SAF2004-05525
PAPEL DE LA CORTEZA PREFRONTAL EN LA FISIOPATOLOGIA DE LA ESQUIZOFRENIA Y ACCION TERAPEUTICADE LOS FARMACOS ANTIPSICOTICOS MEC . REF. SAF2004-05525
MODULACIÓN DE LOS CIRCUITOS CORTICO-MESENCEFÁLICOS POR RECEPTORES 5-HT1A. RELEVANCIA EN LA ACCIÓN TERAPÉUTICA DE LOS FÁRMACOS ANTIPSICÓTICOS. FONDO DE INVESTIGACIÓN SANITARIA . REF. PI060264
AMPC Y NEUROINFLAMACIÓN: IDENTIFICACIÓN DE MOLÉCULAS IMPLICADAS EN LA REGULACIÓN DE LOS NIVELES DE AMPC EN LA ESCLEROSIS MÚLTIPLE Y EN LA ENCEFALOMIELITIS EXPERIMENTAL MEC . REF. SAF2006-10243
DIAGNOSTIC MOLECULAR IMAGING (DIMI) UE . REF. LSHB-CT-2005-512146
AMPC Y NEUROINFLAMACIÓN: IDENTIFICACIÓN DE MOLÉCULAS IMPLICADAS EN LA REGULACIÓN DE LOS NIVELES DE AMPC EN LA ESCLEROSIS MÚLTIPLE Y EN LA ENCEFALOMIELITIS ALÉRGICA EXPERIMENTAL MINISTERIO EDUCACIÓN Y CIENCIA . REF. SAF2006-10243
BASES MOLECULARES DE LA INTERACCIÓN ENTRE "SONIC HEDGEHOG" Y LAS "BONE MORPHOGENETIC PROTEINS" EN EL CONTROL DE LA PROLIFERACIÓN NEURAL MEC . REF. MEC BFU2005 01599

The objective of the group is to develop research projects with results that can be applied in the short term to the improvement of diagnosis and treatment of degenerative and autoimmune neurological diseases. Thus, most of our research is linked to clinical research protocols of the Neurology Unit of Hospital Clínic. The main lines of research include: - Study on experimental models of the physiopathological mechanisms involved in the Parkinson's disease, as well as other movement disorders. - Study on autoimmune mechanisms of neurological diseases related to cancer. - Genetic and expression studies of Parkinson¿s disease, Alzheimer's disease and other neurodegenerative diseases. - Analysis of biological and neuroimaging markers in the diagnosis of neurodegenerative diseases and multiple sclerosis. - Experimental therapies applied to movement disorders, dementias and multiple sclerosis.

Projects financed:

IDENTIFICACIÓN DE NUEVOS ANTÍGENOS EN ENFERMEDADES NEUROLÓGICAS AUTOINMUNES MEDIANTE CRIBAJE DE LIBRERIAS DE CDNA DE SISTEMA NERVIOSO. FIS . REF. PI030028
PAPEL DE LAS PROYECCIONES DOPAMINÉRGICAS EXTRAESTRIATALES Y DE LOS MECANISMOS TALÁMICOS EN EL DESARROLLO DE LAS COMPLICACIONES MOTORAS INDUCIDAS POR LEVODOPA EN EL PARKINSONISMO EXPERIMENTAL. FIS . REF. FIS 05/0094
ANÁLISIS DE ANTICUERPOS CONTRA ANTÍGENOS DE MEMBRANA, Y SU EFECTO PATOGÉNICO, EN ENFERMEDADES DESMIELINIZANTES: ESCLEROSIS MÚLTIPLE Y NEUROMIELITIS ÓPTICA FONDO DE INVESTIGACIONES SANITARIAS . REF. PI060070
. REF. 061130/31

To extend the scientific knowledge of functional aspects of nervous system, integrating both clinical and basic aspects. Our study is focused in both basic and clinical neurophysiology. On theclinical area, our main aims are the characterization of neurophysiological aspects of motor control and pain, the physiopathological aspects of diseases which are co morbid with sleep disorders, epileptic crises and others. On the basic research area, our main aims are the characterization of the physiological cellular mechanisms, both in the ocular physiology and in the mechanisms taking part in the neuronal hyperexcitability in the neuropathic pain. Furthermore, we also work in modulation mechanisms of synaptic transmission.

Projects financed:

DESARROLLO Y VALIDACION DE UNA NUEVA ESCALA DE SOMNOLENCIA FIS . REF. PI 070318
ESTUDIO DE LOS POTENCIALES EVOCADOS Y DE LAS REACCIONES DEL SISTEMA NERVIOSO AUTÓNOMO A LA ESTIMULACIÓN DE LOS RECEPTORES DEL DOLOR EN EL SER HUMANO FIS . REF. PI040970

The research is focused in muscle disease and organic lesions caused by ethanol. The main lines of research are: - Study of the pathogenic mechanisms of alcohol on the organic cells and pathology originated both at neurological and cardiocirculatory levels. - Importance of alcohol in transportation of intracytosolic calcium. - Effects of alcohol on the development of atherosclerosis.- Prognosis of alcoholic myocardiopathy and its best treatment. - Study of muscle and myocardic apoptosis in chronic alcohol consumption. - Study of the physiopathology of muscle diseases, especially muscle immunohistochemical changes, immunogenic changes and angiogenic changes (prognostic factors) of the inflammatory myopathies. - Study of metabolic myopathies, particularly glycogenosis and myoadenylate deaminase deficit. - Study of the myocardic regeneration in the alcoholic myocardiopathy. - Clinical and functional repercussion of chronic fatigue syndrome. - Study of the effects of moderate consumption of wine and the Mediterranean diet in the prevention of cardiovascular diseases.

Projects financed:

INTOXICACIÓN POR MONÓXIDO DE CARBONO: TRATAMIENTO CON OXÍGENO NORMOBÁRICO O HIPERBÁRICO Y SU CORRELACIÓN CAN LA ACTIVIDAD DEL COMPLEJO IV MITOCONDRIAL Y EL GRADO DE PEROXIDACIÓN LIPÍDICA DE LINFOCITOS DE SANGRE PERIFÉRICA FIS . REF. FIS-PI041239
FACTORES RERLACIONADOS CON EL MANTENIMIENTO DE LA INFLAMACIÓN Y LA OCLUSIÓN VASCULAR. IMPLICACIONES EN LA EVOLUCIÓN CLÍNICA DE LOS PACIENTES CON ARTERITIS DE CÉLULAS GIGANTES SAF . REF. SAF 05/06250
EFECTOS DE LA DIETA MEDITERRANEA EN LA PREVENCION PRIMARIA DE LA ENFERMEDAD CARDIOVASCULAR. ESTUDIO PREDIMED INSTITUTO DE SALUD CARLOS III . REF. Red G03/104
IDENTIFICATION AND VALIDATION OF ALCOHOL BIOMARKER SIGNATURAS BY PROTEOMICS. NATIONAL INSTITUTES OF HEALTH ( NIH, BETHESDA, USA) . REF. RFA-AA:06-002
ANGIOGÉNESIS Y CITOCINAS COMO FACTORES PRONÓSTICOS EN LA DERMATOMIOSITIS. CARACTERIZACIÓN DEL SÍNDROME ANTISINTETASA. FIS . REF. FIS PI040464
SARCOPENIA Y DISCAPACIDAD EN EL ANCIANO. FACTORES PREDICTIVOS Y EVOLUTIVOS FIS INSTITUTO CARLOS III . REF. PI050098
COMPARACIÓN DE DOS METODOLOGÍAS DIFERENTES PARA LA DISFUSIÓN DE LA ENSEÑANZA DE LA REANIMACIÓN CARDIOPULMONAR FIS MINISTERIO DE SANIDAD Y CONSUMO . REF. PI 07/0073
MARCADORES BIOLOGICOS DEL FRACASO MULIORGANICO EN EL SHOCK SEPTICO FISS . REF. PI050164
?EFECTO DEL CONSUMO CRÓNICO DE ALCOHOL SOBRE MARCADORES DE INFLAMACIÓN DE LA PARED VASCULAR Y ETAPAS INICIALES DE LA ARTERIOSCLEROSIS? FIS . REF. PI/020611

The main objectives of team research are: - Study of cellular and molecular basis of mechanisms involved in the regulation of neuronal death, as well as research for neuroprotective and/or substitution intracellular pathways of the neuronal populations that degenerate in neurodegenerative diseases. - To elucidate the molecular mechanisms involved in the interaction of cytoskeleton with the system of cellular endomembranes (particularly Golgi's apparatus), as a structural and functional support of membrane traffic and cell mobility. We also want to clarify how this interaction is altered by cytotoxic treatments such as alcohol. During 2005, we have initiated a new line of research on the structural and functional dynamics of Hirano's neurodegenerative bodies.

Projects financed:

ESTUDIO DE LOS MECANISMOS DE ACCIÓN DEL BDNF COMO AGENTE NEUROPROTECTOR EN LA ENFERMEDAD DE HUNTINGTON CICYT, PLAN NACIONAL DE BIOMEDICINAI+D . REF. SAF2005-1335
DIFERENCIACIÓN DE CÉLULAS MADRE HACIA NEURONAS GABAÉRGICAS: UTILIZACIÓN EN TERAPIA SUBSTITUTIVA EN ENFERMEDADES NEURODEGENERATIVAS CICYT, PLAN NACIONAL DE BIOMEDICINAI+D . REF. SAF2006-04202

Our team mainly investigates on severe psychiatric disorders, from neurobiological and therapeutic points of view, with six research lines: bipolar disorder, schizophrenia, depression and anxiety, children and adolescent eating disorders, psychiatric intervention in medical pathology, alcoholism.

Projects financed:

ANÁLISIS DE LOS NIVELES PLASMÁTICOS DE BDNF Y DE INTERLEKIN-1-BETA EN DEPRESIÓN Y ESTUDIO DE SU RELACIÓN CON EL FUNCIONAMIENTO DEL EJE HAA COMO MODELO DE RASGO PREDICTOR DE RESPUESTA AL TRATAMIENTO . PLAN NACIONAL DE I+D+I MINISTERIO DE EDUCACIÓN Y CIENCIA .REF. 4395
SMART . DG V SANCO. UNIÓN EUROPEA .REF. 2007308
DIABETES IN NEUROPSYCHIATRIC DISORDERS . NATIONAL INSTITUTE OF DIABETES& DIGESTIVE & KIDNEY DISEASES (NIDDK) .REF. R01 DK 069265-01
ANÁLISIS DE LOS NIVELES PLASMÁSTICOS DE BDNF Y DE INTERLEUKIN 1BETA EN DEPRESIÓN Y ESTUDIO DE SU RELACIÓN CON EL FUNCIONAMIENTO DEL EJE HHA COMO MODELO DE RASGO PREDICTOR DE RESPUESTA AL TRATAMIENTO . PLAN NACIONAL DE INVESTIGACIÓN CIENTÍFICA Y DESARROLLO TECNOLÓGICO 2004-2007 .REF. SAF2005-07852-C02-02/
CARACTERÍSTICAS PSICOPATOLÓGICAS, NEUROPSICOLÓGICAS Y DE NEUROIMAGEN COMUNES Y DIFERENCIALES EN NIÑOS Y ADOLESCENTES HIJOS DE PACIENTES CON ESQUIZOFRENIA O CON TRASTORNO BIPOLAR . FIS (INSTITUTO DE SALUD CARLOS III) .REF. PI070066
ALTERACIONES NEURORRADIOLÓGICAS EN EL TRASTORNO OBSESIVO-COMPULSIVO Y EN UN SUBGRUPO DE ANOREXIA NERVIOSA . FIS, INSTITUTO DE SALUD CARLOS OIII .REF. PI040829
FUNCIONAMIENTO Y DISCAPACIDAD EN LOS TRASTORNOS AFECTIVOS . FONDO DE INVESTIGACIÓN SANITARIA INTITUTO CARLOS III .REF. PI050206

To study the consequences of brain dysfunctions and injury on cognition and behaviour. The preferred technique used to carry out research is magnetic resonance, in both structural and functional areas. Our group makes use of a neuroimaging analysis laboratory equipped with diverse high capabilities workstations, which use the ANALYZE and SPM medical imaging software. The main lines of research are: - Psychobiological basis of memory impairment related to degenerative and psychiatric diseases. - Cognitive functions of frontal lobe-basal system. - Brain plasticity: long-term consequences of brain lesion in childhood. - Neuropsychology of psychiatric disorders.

Projects financed:

PAPEL DE LA RESONANCIA MAGNÉTICA FUNCIONAL EN LA LOCALIZACIÓN DE LA AREA EPILEPTOGENA EN PACIENTES CON EPILEPSIA FOCAL FARMACORESISTENTE FIS . REF. PI050052
APLICACIÓN DE LA RESONANCIA MAGNÉTICA AL ESTUDIO DEL ESTADO VEGETATIVO Y AL ESTADO DE MÍNIMA CONCIENCIA EN LOS TRAUMATISMOS CRÁNEO-ENCEFÁLICOS MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2007-66077
APLICACIÓN DE LA RESONANCIA MAGNÉTICA ESTRUCTURAL Y FUNCIONAL AL ESTUDIO DEL ESTADO VEGETATIVO Y EL ESTADO MÍNIMO DE CONCIENCIA EN LOS TRAUMATISMOS CRÁNEO-ENCEFÁLICOS? MINISTERIO DE EDUCACIÓN Y CIENCIA. . REF. SAF 2007-0677
APLICACIÓN DE LA RESONANCIA MAGNÉTICA AL ESTUDIO DEL ESTADO VEGETATIVO Y AL ESTADO DE MÍNIMA CONCIENCIA EN LOS TRAUMATISMOS CRÁNEO-ENCEFÁLICOS . MINISTERIO DE EDUCACIÓN Y CIENCIA . REF. SAF2007-66077

The neurobiology unit conducts research on excytotoxic and apoptotic neuronal death molecular mechanisms with the aim to identify new therapeutic targets for the treatment of neurodegenerative diseases. Another objective is to understand the molecular and cellular interactions between neuronal death and neurogenesis processes, present during age-related and Alzheimer-relate neurodegeneration.

Projects financed:

PROYECTO INVESTIGACIÓN I+D DEL VII- PROYECTO MARCO . PROYECTO MARCO CEE . REF. FP7-ICT-2007
ESTIMULACIÓN CEREBRAL PROFUNDA EN EL TRANSTORNO OBSESIVO-COMPULSIVO ALTAMENTE RESISTENTE: VARIACIONES EN EL RENDIMIENTO COGNITIVO Y LA PERSONALIDAD EN UNA MUESTRA DE 10 PACIENTES FIS . REF. PI071044

The objectives of the group and the lines of research are foncused on: - Eating disorders. - Affective disorders. - Obsessive disorders. - Pathological gambling.

Projects financed:

PROYECTO INVESTIGACIÓN I+D DEL VII- PROYECTO MARCO . PROYECTO MARCO CEE . REF. FP7-ICT-2007
ESTIMULACIÓN CEREBRAL PROFUNDA EN EL TRANSTORNO OBSESIVO-COMPULSIVO ALTAMENTE RESISTENTE: VARIACIONES EN EL RENDIMIENTO COGNITIVO Y LA PERSONALIDAD EN UNA MUESTRA DE 10 PACIENTES FIS . REF. PI071044

The lines of research of the group of neurological and neurogenetic diseases are focused on the following: - Genetics of hereditary ataxias. - Charcot-Marie-Tooth genetics. - Epidemiology and clinical research on multiple sclerosis. - Epidemiology of Amyotrophic Lateral Sclerosis (ALS). - Lexical access disorders in language production. - Investigation into prothrombotic mechanisms in patients with symptomatic and asymptomatic carotid stenosis. - Hereditary peripheral neuropathies. -Electrical activity in muscle diseases. - Epidemiology of dementia and its main subtypes (Alzheimer's, vascular dementia, diffuse Lewy-body disease, frontotemporal dementia) in the population under 70 of Prat de Llobregat.

Projects financed:

REDCIEN DE INVESTIGACIÓN: CENTRO DE INVESTIGACIÓN DE ENFERMEDADES NEUROLÓGICAS REDCIEN BELLVITGE/UB. INSTITUTO DE SALUD CARLOS III. MINISTERIO DE SANIDAD Y CONSUMO. . REF. RED100 C3-006

The task of this group is mainly framed in the field of applied clinical research and is developed in collaboration with various clinical groups from Hospital Clínic de Barcelona (HCB) and outside HCB. The research is performed on the following: - Circulating tumour markers. - Consolidation of the diagnostic guidelines of clnical use of Tumoural Markers. - Incorporation of a quantitative technique for the detection of circulating cells - Chemosensitivity of human tumours. - Apoptosis. - Research on the implementation of cytokines in the development and progression of cancer. - Markers used in Pharmacogenetics.

Projects financed:

POLIMORFISMOS MAO A (T941G<9) MAO B (INTRON 13A/G) COMT(-A278G), ACE(I/D)CYP2D6*3,*4,*5,*6) Y CYP1A2 (*1C,*1F) Y RIESGO DE EXTRAPIRAMIDALISMO POR ANTIPSICOTICOS EN LA ESQUIZOFRENIA Y OTRAS PSICOSIS. FIS- INSTITUTO CARLOS III- MINISTERIO DE SANIDAD Y CONSUMO . REF. PI060182
POC4 LIFE. MULTIPARAMETRIC QUANTUM DOT BIOASSAY FOR POINT OF CARE DIAGNOSIS . UE . REF. POC4life. 037933

The objectives of research of the group are: - To identify genetic and molecular mechanisms involved in the development and progression of human neoplasia. - Development of strategies in order to transfer tumour knowledge from basic research to clinical practice. This objective is to be achieved through the identification of parametres permitting a better diagnosis and follow-up of the neoplasic disease, and with the identification of possible therapeutic targets and mechanisms of action of drugs.

Projects financed:

ESTUDIO DE LA PREVALENCIA DEL VIRUS DEL PAPILOMA HUMANO (HPV) EN LOS CARCINOMAS ESCAMOSOS DEL TRACTO RESPIRATORIO SUPERIOR.IMPLICACIONES DIAGNOSTICAS Y PRONOSTICAS . ASOCIACION ESPAÑOLA CONTRA EL CANCER (AECC) . REF.
. REF. 5
MECANISMOS DE INESTABILIDAD GENOMICA EN EL DESARROLLO Y PROGRASION DE NEOPLASIAS LINFOIDES . SAF . REF. 2002-03261
ANÁLISI POR MICROARRAYS DE LOS GENES DIANAS DE LOS MICORRNA ALTERADOS EN SU DOSIS GÉNICA EN LINFOMAS DE CÉLULAS DEL MANTO . FIS . REF. PI050244
IDENTIFICACIÓN DE NUEVOS GENES SUPRESORES DE TUMORES Y CARACTERIZACIÓN EPIGENÉTICA DE LOS LINFOMAS DE CÉLULES DEL MANTO. IMPLICACIÓN EN EL DESARROLLO Y PROGRESIÓN DE MCL. . LYMPHOMA RESEARCH FOUNDATION . REF. V-2007-LRF-7168-0
ANÁLISIS DE LA FIRMA METASTÁTICA EN EL CARCINOMA ESCAMOSO DE LA LARINGE. . MSCO - MINISTERIO DE SANIDAD Y CONSUMO . REF. PI060189

The main research objectives of the team are: - To develop techniques in order to improve diagnosis and prognostic evaluation and response to the therapy of cancer patients. - Development and application of new therapies in oncology.

Projects financed:

ESTUDIO FASE II DE TRATAMIENTO NEOADYUVANTE CON IFOSFAMIDA A DOSIS ALTAS Y RADIOTERAPIA CONCOMITANTE EN SARCOMAS DE PARTES BLANDAS E IDENTIFICACION DE MARCADORES PREDICTORES DE RESPUESTA. FISSS . REF. -
VALORACIÓN DE PET-TC (TOMOGRAFÍA DE EMISIÓN DE POSITRONES- TOMOGRAFÍA COMPUTARIZADA) DE BAJA DOSIS SIN UTILIZACIÓN DE CONTRASTE RADIOLÓGICO COMO ÚNICA EXPLORACIÓN DE IMAGEN PARA LA ESTADIFICACIÓN Y RE-ESTADIFICACIÓN DE LOS LINFOMAS. INSTITUTO SALUD CARLOS III . REF. PI070277

The research group is constituted by the Molecular Genetics Laboratory and the Human Genetic Laboratory. Our research activity is framed within the paradigm of current physiology: study of mechanisms of gene expression as a new approach to the study of the organism's functions. Currently, our work is directed to the proteomic and molecular characterisation of spermatozoids in infertile and control patients, on the one hand, and to the study of the mechanisms involved in tumoural angiogenesis and in the transition epithelium- mesenchyme of tumoural cells.

Projects financed:

PROTEOMICA DEL ESPERMATOZOIDE EN PACIENTES INFERTILES, EN MODELOS KNOCK OUT Y MECANISMO DE LA TRANSICIÓN NUCLEOHISTONA-NUCLEOPROTAMINA . MINISTERIO DE CIENCIA Y TECNOLOGÍA . REF. BFU2006-03479/BMC

The objective of the group is to study and characterise the hereditary disease in its clinical, cytogenetic and molecular aspects. The main lines of research: - Identification of the genetic bases of mental deficiency linked to X-chromosome (XLMR) both syndromic and non-syndromic through CGH-array. - Study of FXTAS (Fragile X Tremor Ataxia Syndrome) a new type of cerebellar ataxia associated to some carriers of the permutation of the Fragile X syndrome (FXS). - Detection of criptical chromosomal unbalances and identification of new phenotypes through techniques of molecular cytogenetics. One is conducted in the framework of pre-natal diagnosis, and the other of post-natal diagnosis. - Study of susceptibility and response to treatment through SNPs in melanoma.

Projects financed:

CARACTERIZACIÓN DE DESEQUILIBRIOS CROMOSÓMICOS, ANÁLISIS DE LOS PUNTOS DE ROTURA EN REORDENAMIENTOS APARENTEMENTE EQUILIBRADOS E IDENTIFICACIÓN DE CROMOSOMAS MARCADORES MEDIANTE MICRODISECCIÓN CROMOSÓMICA Y POSTERIOR ANÁLISIS CON TÉCNICAS DE ARRAY-CGH Y/O . FIS DEL MINISTERIO DE SANIDAD Y CONSUMO . REF. PI070385
DETECCIÓN DE DESEQUILIBRIOS CROMOSÓMICOS SUBMICROSCÓPICOS Y SU CORRELACIÓN CON EL FENOTIPO FETAL MEDIANTE LA APLICACIÓN DE TÉCNICAS DE CITOGENÉTICA MOLECULAR EN EL DIAGNÓSTICO PRENATAL DE MALFORMACIONES FETALES . FIS DEL MINISTERIO DE SANIDAD Y CONSUMO, ICIII . REF. PI05/0096

We want to improve clinical results obtained with the conventional haemopoietic progenitor cell transplantation, to research on the prognostic, clinical and biological factors and to assess new forms of cell therapy. Of particular interest are the activities of the group directed to assess the effectiveness of new prophylactic and therapeutic measures aiming to the reduction of the incidence, morbidity and mortality of the main complications of transplantation, such as graft failure, graft disease against host and infections. Among other aspects of our research we emphasise: the incorporation of new conditioning regimes (aka of reduced intensity); prevention and treatment of the graft-versus-host disease through new drugs; use of monoclonal antibodies; incorporation of the value of reconstitution of dendritic cells; preventive treatment of the cytomegalic disease through specific lymphocytes against the virus and the utilisation of new and more effective antifungals; and the prevention of immediate post-transplantation toxicity. Given the importance of this last aspect, we have started two projects analysingthe value of the endothelial lesion as a prediction of the liver veno-occlusive disease, and a study on urine proteomics, in collaboration with the Nephrology Unit, to make an early detection of severe kidney toxicity. Another section of priority attention is the assessment of new therapeutic indications and new modalities of transplantation. Among the latter is cell therapy through the creation of haemopoietic chimerism as a form of adoptive antitumour immunity for high-risk patients for a conventional transplantation, and autologousand allogenic home transplantation.

Projects financed:

DETECCIÓN Y CUANTIFICACIÓN DE MARCADORES STEM MEDIANTE ANALISIS DE MICRO-RNAS EN PACIENTES CON CANCER DE PULMON Y EN TEJIDO EMBRIONARIO HUMANO FIS . REF. PI060087

The main objective of the members of the group is clinical and transference research in cancer, including haematological neoplasia and solid tumours from a triple point of view: physiopathology, prognosis and development of new treatments. The main lines of research are: - Lymphoproliferative syndromes (lymphomas and chronic lymphocytic leukaemia). - Multiple myeloma. - Myeloproliferative syndromes. - Acute leukaemia. - Mechanisms of tumoural chemoresistance. - Stem cell, microenvironment and metastasis mechanisms. - Pharmacodynamic and prediction studies to therapeutic response. - Study of minimal residual disease.

Projects financed:

MIELOMA MÚLTIPLE Y OTRAS GAMMAPATÍAS: DE LA GÉNESIS A LA TERAPÉUTICA . INSTITUTO DE SALUD CARLOS III . REF. RD06/0020/0005
"ZAP-70, PROLIFERACIÓN CELULAR Y APOPTOSIS EN LA LEUCEMIA LINFÁTICA CRÓNICA" . FONDO DE INVESTIGACIÓN SANITARIA . REF. FIS05/0213
ESTUDIO DE LA RELACIÓN ENTRE LA PRESENCIA DE POLIMORFISMOS GENÉTICOS EN LOS GENES MDR1, HOCT1 Y AGP1 Y LA RESPUESTA AL TRATAMIENTO CON IMATINIB DE LOS PACIENTES CON LEUCEMIA MIELOIDE CRÓNICA EN FASE CRÓNICA DE DIAGNÓSTICO RECIENTE. . FONDO DE INVESTIGACIÓN SANITARIA, MINISTERIO DE SANIDAD Y CONSUMO . REF. U-2006-FS060038-O
NUEVOS ESTUDIOS INMUNOGENOTIPICOS EN LA CLASIFICACIÓN Y TRATAMIENTO DE LA LEUCEMIA MIELOIDE AGUDA Y SÍNDROMES MIELODISPLÁSICOS. . MINISTERIO DE SANIDAD Y CONSUMO. INSTITUTO DE SALUD CARLOS III. . REF. 05/0195

The objective of the reseacrh team is the epidemiological, genetic, molecular and physiopathological study of malign homeopathies and erythrocyte pathology. The main lines of research are: - Molecular basis of the regulation of apoptosis induced by drugs in lymphoid neoplasia. Research on new strategies for the treatment of these diseases. - Cytological, immunophenotypical and molecular study of malign haemopathies. - Molecular study of congenital disorders of erythrocytes and of physiopathological mechanisms involved in the production and destruction of erythrocytes as a cause of anaemia or erythrocytosis. - Genetic and epidemiological study of haemoglobinopathy and thalassemia.

Projects financed:

DESARROLLO DE UN BIOBANCO PARA MUESTRAS BIOLÓGICAS PROSPECTIVAS DE PACIENTES ONCOLÓGICOS COMO SOPORTE A LA INVESTIGACIÓN BIOMÉDICA. . MINISTERIO SANIDAD Y CONSUMO . REF. FIS PI070301
IDENTIFICACIÓN DE NUEVAS DIANAS CON POTENCIAL TERAPÉUTICO EN NEOPLASIAS LINFOIDES . MINISTERIO EDUCACION Y CIENCIA . REF. SAF06-8850
EPIDEMIOLOGÍA Y FACTORES PRONÓSTICOS DE LOS PACIENTES AFECTADOS DE LINFOMAS CUTÁNEOS DE CÉLULAS T (LCTT) . FONDO DE INVESTIGACIÓN SANITARIA . REF. PI 0500548
CARACTERIZACIÓN BIOLÓGICA DE LA LEUCEMIA AGUDA MIELOIDE CON DISPLASIA MULTÍNEA. IMPLICACIONES PRONÓSTICAS Y TERAPÉUTICAS . INSTITUTO DE SALUD CARLOS III . REF. FIS 03/0423
BASES CELULARES DE LA RESPUESTA AL TRATAMIENTO EN PACIENTES CON SÍNDROMES LINFOPROLIFERATIVOS CRÓNICOS DE LÍNEA B . FONDO DE INVESTIGACIÓN SANITARIA . REF. 04/1051

The main objectives and lines of research are: - To evaluate congenital and acquired defects of haemostasis and their correction by pharmacology and/ or transfusion. - To make a laboratory characterisation of haemorrhage and thrombosis phenotypes. - To study the basic mechanisms regulating the blood cells function and their interplay with vascular wall and with other cells. - To assess the therapeutic efficiency and the possible adverse effects of several blood compounds or synthetic substitutes, and to investigate preparation procedures for these compounds in order to improvethe quality and safety of products. - To characterise animal models of haemostasis, preferably in mouse.

Projects financed:

SEROTONINA Y RECEPTORES SEROTONINÉRGICOS EN LAS PLAQUETAS: UNA CONEXIÓN ENTRE LOS MECANISMOS DE LA DEPRESIÓN Y EL AUMENTO DE RIESGO CARDIOVASCULAR . MINISTERIO DE SANIDAD Y CONSUMO. FONDO DE INVESTIGACIÓN SANITARIA . REF. FIS 04/0887
CLINICAL TRIAL TO EVALUATE THE THERAPEUTIC EFFICACY AND SAFETY OF INTERCEPT PLATELETS STORED FOR UP TO SEVEN DAYS AFTER COLLECTION (TESSI). . CERUS EUROPE BV. . REF. Study CLI 00042
CANCER Y TROMBOEMBOLISMO: IMPORTANCIA DE LA GENERACIÓN DE TROMBINA RELACIONADA CON LAS MICROPARTICULAS PROCOAGULANTES CIRCULANTES Y LOS POLIMORFISMOS DE LAS MISMAS EN EL DESARROLLO DE TROMBOSIS EN LOS PACIENTES CON CANCER . FIS . REF. PI070387
IMPORTANCIA DE LOS POLIMORFISMOS GENETICOS RELACIONADOS CON LA ADHESION Y FUNCION PROCOAGULANTE DE LAS MICROPARTICULAS DURANTE LA FORMACION DEL TROMBO EN EL SINDROME ANTIFOSFOLIPIDICO: RELACION CON LAS TROMBOSIS. . FISS . REF. PI0050204

The objectives of research of this group are: - Development of non-invasive imaging techniques for the diagnosis of melanoma. - Study of genetic basis involved in melanoma susceptibility and photocarcinogenesis of melanoma. - Development of target-specific and immunological therapeutic strategies of melanoma. - Application of artificial intelligence systems in order to assess complex data in melanoma, by combining imaging, epidemiological, clinical and molecular data.

Projects financed:

OBTENCIÓN DE CÉLULAS DENDRÍTICAS CARGADAS CON PROTEÍNAS DE ESTRÉS TÉRMICO TUMORALES AUTÓLOGAS EN CONDICIONES GMP Y SU APLICACIÓN TERAPÉUTICA. . FIS . REF. PI020364

The main objectives of the team research are: - Molecular characterisation of digestive tumours through genome and transcriptome analysis. - Study of molecular bases of hereditary colorectal cancer. - Molecular diagnosis of digestive tumours. - Angiogenesis and colorectal cancer. - Development of animal models with orthotopic implantation of digestive tumours (pancreas, colon and liver) in athymic mice. -Transplant and resection in liver cancer.

Projects financed:

TASA DE RECIDIVA LOCAL Y SUPERVIVENCIA DE LOS PACIENTES CON CÁNCER DE RECTO INTERVENIDOS MEDIANTE EXÉRESIS TOTAL DEL MESORRECTO?. ESTUDIO MULTICÉNTRICO ESPAÑOL FONDO INVESTIGACIÓN SANITARIA . REF. 05/2276
TRASPLANTE HEPATICO Y CALIDAD DE VIDA EN LA POBLACION ESPAÑOLA. SENSIBILIDAD AL CAMBIO DEL NUEVO CUESTIONARIO ESPECIFICO LDQOL PARA HEPATPATIAS Y TRASPLANTE FIS . REF. 03/0079
VALIDACIÓN DE LA TÉCNICA DE MLDA O MUTATIONAL LOAD DISTRIBUTION ANÁLISIS COMO MÉTODO DIAGNÓSTICO EN CÁNCER DE PÁNCREAS FIS . REF. PI06/0415
ESTUDIO FASE II DE TRATAMIENTO NEOADYUVANTE CON IFOSFAMIDA A DOSIS ALTAS Y RADIOTERAPIA CONCOMITANTE EN SARCOMAS DE PARTES BLANDAS E IDENTIFICACION DE MARCADORES PREDICTORES DE RESPUESTA FIS ISCIII PARA PROYECTOS DE INVESTIGACIÓN CLÍNICA INDEPENDIENTE . REF. EC07/90415
IDENTIFICACIÓN Y VALIDACIÓN DE MARCADORES PROTEICOS EN PLASMA PARA EL DIAGNÓSTICO Y EL PRONÓSTICO DEL CÁNCER COLORRECTAL FIS . REF. FIS 05/1006
ESTUDIO DE LA FAMILIA DE GENES EMK1 COMO FACTORES DE RIESGO DE RECHAZO AGUDO EN EL TRANSPLANTE RENAL HUMANO INSTITUTO DE SALUD CARLOS III-FIS . REF. PI020766
HYPOXIC RENAL PROLIFERATION, ACRONOMO: PROLIGEN 6TH FP-UE- LIFESCIHEALT-7 . REF. Proposal 036813

The main field of research are: - Nutrition and cancer. - Tobacco and cancer. - Environmental pollutants and cancer. - Genetic susceptibility and gene-environment interaction.

Projects financed:

ENVIRONMENTAL FACTORS, HELICOBACTER PYLORI AND THE GASTRIC CANCER RISK IN EUROPEAN POPULATIONS (EUR-GAST I) EUROPEAN COMMISSION . REF. Expediente QLRT-2000-01049.

The main objectives of research of the team are: - Regulation of apoptosis in chronic lymphocytic leukemia. - Molecular mechanisms that confer resistance to the apoptotic effects of TGF-beta: implications in tumour progression. - Molecular mechanisms related to chemoresistance in gliomas, ovarian, and prostate cancer. - Regulation of apoptosis and cancer by the glycolytic metabolism.

Projects financed:

EL METABOLISMO GLICOLÍTICO COMO REGULADOR DE LA APOPTOSIS Y EL CANCER FIS . REF. 05/00036

The main objectives of the research team are: - Evaluation of molecular prognostic factors and response predictors in the treatment of solid tumours with different chemosensitivity: bladder cancer, germ-cell tumours, colorectal cancer, breast cancer. - Study of the relationship between alterations in diverse oncogenes and the angiogenic capacity of solid tumours. - Preclinical and clinical evaluation of new natural and synthetic substances such as anti-tumour drugs: selective liposomes and anti-neoplastic agents derived from bacteria. - Apoptosis in the progression and spread of breast cancer.

Projects financed:

ALTERACIONES CROMOSÓMICAS Y DEL GENOMA MITOCONDRIAL EN CANCER DE PRÓSTATA MCYT . REF. : SAF05/0166

The main lines of research are: - Cancer immunology. - Cellular signalling and modulation of the immune response. Development of new immunosuppressive drugs. - Cystic fibrosis. - Gene repair and transfer; transplant and inflammatory processes. - Genetic Variability and Cancer Syndromes (VAgeCA group). - Male infertility. - Megalencephalic leukoencephalopathy. - Mitochondrial genetics. - Peroxisome: a System Biology. - Study of the molecular bases of the cystinuria and the lysinuria with intolerance to proteins. - X-linked Adrenoleukodystrophy.

Projects financed:

IMPORTANCIA DE LA SEÑALIZACIÓN VÍA CD40 EN PROCESOS INMUNOINFLAMATORIOS DE ORIGEN VASCULAR. IMPLICACIONES DIAGNÓSTICAS Y TERAPÉUTICAS EN EL MANEJO DEL ICTUS INSTITUT D'INVESTIGACIÓ BIOMÈDICA DE BELLVITGE - CENTRO GENÉTICA MÉDICA Y MOLECULAR . REF. PI071001
MECANISMOS MOLECULARES EN LA DISFUNCIÓN DE CFTR. CUANTIFICACIÓN Y CARACTERIZACIÓN DE TRANSCRITOS ABERRANTES EN FIBROSIS QUÍSTICAS Y FENOTIPOS RELACIONADOS ISCIII, FIS . REF. PI050804

The lines of research of the group are: - Evaluation of determinants for tobacco addiction and analysis of the impact on cancer incidence and death. - Genetic counselling in hereditary cancer. - Evaluation of the use of radiotherapy in oncology patients and its consequences on healthcare planning. - Evaluation of the results of cancer-screening programmes and of population participation determinants. - Development of computer and epidemiological methodology for the Catalonian cancer population register.

Projects financed:

THE IMPACT OF KEY DETERMINANTS ON THE CURRENT AND FUTURE BURDEN OF CANCER IN EUROPE. EUROCADET. EUROCADET . REF. SP23-CT2005-006528
EVALUACIÓN DEL IMPACTO DE LA NUEVA "LEY REGULADORA DE LA VENTA, EL SUMINISTRO, EL CONSUMO Y LA PUBLICIDAD DE LOS PRODUCTOS DEL TABACO" EN LOS NIVELES DE EXPOSICIÓN AL HUMO AMBIENTAL DEL TABACO: SUBPROYECTO SOBRE NIVELES DE COTININA EN SALIBA DE TRABAJADOR FONDO DE INVESTIGACIÓN SANITARIA . REF. PI052072

The objectives of the group and the lines of research are focused on: - Clinicobiological correlations in lymphoid tumours. - Alloreactivity and chimerism. - Minimum residual illness. - New therapeutic targets. - Infections in neutropenic patients. - Post- solid-organ transplant lymphomas. - Acute leukaemias. - Chronic myeloproliferative syndromes.

Projects financed:

The group of systemic diseases, motor function and ageing is focused in the following lines of research: - Epidemiological and evolutive characteristics, and adaptation of heart-failure management in the elderly. - Improvement of the prognosis of elderly hip-fracture patients through the use of a clinical trajectory. - Sarcoidosis: epidemiological studies with other hospitals in Barcelona, and clinical (neurosarcoidosis, chronic sarcoidosis), immunopathogeny and genetic studies (studies of polymorphisms of the angiotensin converting enzyme in different forms of sarcoidosis, genetic study of Löfgren's syndrome). - Clinical and therapeutic studies on lupus erythematosus and systemic vasculitis.
Control of patients with hypogammaglobulinemia. - Role of anti-TNFa in the treatment of articular inflammatory diseases. - Renal involvement in rheumatoid arthritis. - Alterations in lipid metabolism in patients with rheumatoid arthritis and relation to the activity of the patient. - Osteoporosis in systemic illnesses. - Clinical studies of new treatments for medical motor function diseases. - Pre-operative prognostic factors for functional improvement in total arthroplasties.

Projects financed:

ESTUDIO INMUNOPATOGÉNICO Y ETIOLÓGICO DE LA SARCOIDOSIS CON TÉCNICAS DE BIOLOGÍA MOLECULAR. CORRELACIÓN CLÍNICA Y PRONÓSTICA FONDO DE INVESTIGACION SANITARIAS . REF. 98/774
EVALUACIÓN DE UN PROGRAMA DE VIGILANCIA ACTIVA COMO INTERVENCIÓN PREVENTIVA DE COLONIZACIÓN INFECCIÓN POR S. AUREUS RESISTENTE A LA METICILINA EN UNIDADES DE HOSPITALIZACIÓN CONVENCIONALES FIS . REF. PI o 7/90661

The group is focused on the study of cardiovascular diseases. The lines of research are: - Minimum myocardial damage in acute coronary syndrome without ST segment elevation and in percutaneous coronary interventions. - Endothelial dysfunction in the epicardial arteries in AMI and analysis of microcirculation perfusion in acute coronary syndromes. - Initial endothelial dysfunction as a predictor in the onset of coronary vasculopathy in heart-transplant patients. -Thrombosis-related haemostatic alterations.

Proyectos financiados

HIPERMETILACIÓN DE LA REGIÓN PROMOTORA DE LOS GENES MLH1, MGMT, CDKN2A, RASSF1A, CDX1 Y SFRP1 EN MUCOSA COLORRECTAL NO TUMORAL COMO FACTOR FAVORECEDOR DEL DESARROLLO DEL CÁNCER COLORRECTAL. PLAN NACIONAL DE I + D (SAF) . REF. SAF 2007-64873
MOSAR NETWORK UNION EUROPEA . REF. LSHP-CT-2007-037941

The objectives of the research team are: - Biological monitoring of acute lung injury by analysis of exhalate and circulating cytokines. - Regulation processes of pulmonary repair and its biomechanical expression. - Diagnosis and treatment of obstructive sleep apnea syndrome. - Home oxygen therapy and non-invasive mechanical ventilation in the treatment of advanced chronic respiratory failure. - Immunopathology of acute lung injury and bronchial asthma. - Respiratory alterations in neuromuscular illnesses. - Home assistance with advanced chronic respiratory failure. - Prolonged intubation in acute lung injury (ALI) and weaning. - Diagnosis and treatment of conventional and opportunist lung infection. - Volumetric capnography in chronic obstructive lung disease.

Projects financed:

ESTUDIO DE VALIDEZ DIAGNÓSTICA Y ANALISI DE COSTE DE LA POLIGRAFÍA RESPIRATORIA DOMICILIARIA CON TRANSMISIÓN TELEMÁTICA DE LOS DATOS. FIS . REF. Beca FIS PI 051856

The main objectives of research of the team are: - Diagnosis of osteoarticular infection. - Diagnosis of inflammatory bowel disease. - Radioguided localisation of tumour lesions. - Radioisotopic localisation of sentinel node in breast cancer. - Development of new methods for quality control of Nuclear Medicine instruments. - Quality assurance handbook. - Radiofrequency treatment of osteoid osteomas. - Vertebroplasty. - Radiofrequency treatment of unresectable renal tumours. - Treatment of spastic back pain with botulinum toxin in post-ictus patients with pyramidal pain not responding to conservative measures. - Neurolytic blocking with root lysis.

Projects financed:

The main objectives of the group cover the molecular basis of organ reject, to develop strategies at preclinical levels that may improve the survival of the implant. Moreover, there is research on the role of immunotherapy towards infection and cancer, in order to be used in the clinical field.

Projects financed:

TERÁPIA XENOGÉNICA PARA EL TRATAMIENTO DE DEFECTOS DE CARTÍLAGO . FUNDACIÓN DE INVESTIGACIÓN MÉDICA MÚTUA MADRILEÑA . REF. 338/05
PATRÓN DE XENOANTICUERPOS TRAS TRANSFUSIÓN DE SANGRE XENOGÉNICA E INMUNIDAD NATURAL CONTRA INFECCIONES BACTERIANAS. FIS . REF. PI050861

The lines of research include: - Allorecognition and tolerance. - Complications: cardiovascular, bone and mineral metabolism, infections, tumours. - Epidemiology. - Graft failure. - Immunosuppression. -Ischemia and reperfusion. - Quality of life. - Experimental Renal Transplant.

Projects financed:

ACTIVACIÓN, APOPTOSIS Y ESTRES OXIDATIVO EN LINFOCITOS DE PACIENTES CON ENFERMEDAD DE PARKINSON Y OTRAS PATOLOGIAS NEURODEGENERATIVAS . FONDO DE INVESTIGACIONES SANITARIAS DE LA SEGURIDAD SOCIAL . REF. PI020076
HYPOXIC RENAL PROLIFERATION . EPSS-FP6 (6º PROGRAMA MARCO EUROPEO) . REF. EPSS-FP6
TERÁPIA CELULAR Y TERÁPIA GÉNICA APLICADAS AL TRANSPLANTE RENAL EXPERIMENTAL. . FIS . REF. FIS06/0230
ESTUDIO DE EPIDEMIOLOGÍA CLÍNICA Y MOLECULAR DE LA COLONIZACIÓN POR STAPHYLOCCOCCUS AUREUS EN PACIENTES HEMODIALIZADOS. VIGILANCIA EVOLUTIVA Y APARICIÓN DE RESISTENCIA A MUPIROCINA. . FISS . REF.
ALTERACIONES DE LA HOMEOSTASIS DE LA GLUCOSA POST-TRASPLANTE RENAL . FIS . REF. PI040177
ESTUDIO FIPSE DE TRANSPLANTE HEPÁTICO EN PACIENTES INFECTADOS POR EL VIH EN ESPAÑA. . FIPSE . REF. Estudio GESIDA 45-05
INFLAMACION DE BAJO GRADO, NEFROPATIA CRONICA DEL TRANPLANTE Y ATEROMATOSIS POSTTRANPLANTE . FIS . REF. PI040086
ESTUDIO PROSPECTIVO CONTROLADO SOBRE LA EFICÀCIA DE UN REGIMEN INMUNOSUPRESOR SIN CORTICOIDES EN EL TRASPLANTE HEPÁTICO . FUNDACIÓ DE LA MARATÓ DE TV3 . REF. 00-1410

The lines of research of the group are: - Infections of the central nervous system. - Antibiotics policy.
Epidemiology of pneumococcal disease. - Epidemiology of resistance to antibiotics. - Molecular mechanisms of resistance to antibiotics. - Infections in transplant patients. - Respiratory infections. - Foreign-body infections. - Bacteremic infections. - Investigations in AIDS patients. - Infection due to multiresistant micro-organisms.

Projects financed:

DETECCIÓN RÁPIDA DE LA RESISTENCIA A LOS FÁRMACOS DE PRIMERA LÍNEA EN MYCOBACTERIUM TUBERCULOSIS MEDIANTE CHIPS DE DNA DE BAJA DENSIDAD. ESTUDIO IN VITRO DE LA INFECTIVIDAD EN MACRÓFAGOS HUMANOS DE LOS GENOTIPOS RESISTENTES MÁS RELEVANTES. . FONDOS DE INVESTIGACIÓN SANITARIA . REF. PI060328
ESTUDIO DE LA EFICACIA ANTIMICROBIANA EN LA INFECCIÓN EXPERIMENTAL ASOCIADA A CUERPO EXTRAÑO POR S.AUREUS METICILLIN SENSIBLE Y METICILLIN RESISTENTE . FIS . REF. PI04/0103
ESTUDIO EXPERIMENTAL DEL TRATAMIENTO DE LA MENINGITIS POR S. AUREUS SENSIBLE Y RESOSTENTE A BETALACTÁMICOS Y GLICOPÉPTIDOS. . FONDO DE INVESTIGACIONES SANITARIAS, INSTITUTO DE SALUD CARLOS III . REF. FIS 051532
SIMVASTATINA EN LA NEUMONÍA ADQUIRIDA EN LA COMUNIDAD QUE REQUIERE HOSPITALIZACIÓN. ESTUDIO ALEATORIZADO, DOBLE-CIEGO, CONTROLADO CON PLACEBO . FIS MINISTERIO DE SANIDAD Y CONSUMO . REF. PI070864
RESISTENCIA A METICILINA EN S.AUREUS: EVOLUCIÓN INTRAHOSPITALARIA Y ADAPTACIÓN A LA COMUNIDAD . INSTITUTO DE SALUD CARLOS III. FIS . REF. PI070944
COLONITZACIÓ I INFECCIÓ PER ESCHERICHIA COLI PRODUCTOR DE BETALACTAMASES D?ESPECTRE ESTÈS EN MALALTS NEUTROPÈNICS AMB CÀNCER. . FUNDACIÓ LA MARATÓ DE TV3 . REF. 051610
EPIDEMIOLOGÍA CLÍNICA Y MOLECULAR DE LA ENFERMEDAD NEUMOCÓCICA INVASIVA EN ADULTOS EN LA ERA POSTVACUNAL. CAMBIOS EN LA DISTRIBUCIÓN DE LOS SEROTIPOS. TIPIFICACIÓN MOLECULAR DE LOS CLONES DE S. PNEUMONIAE. . FONDOS DE INVESTIGACIÓN SANITARIA (FIS) . REF. FIS PI060647
EPIDEMIOLOGIA CLÍNICA Y MOLECULAR DE LA ENFERMEDAD NEUMOCIDA INVASIVA EN ADULTOS EN LA ERA POSTVACUNAL. CAMBIOS EN LA DISTRIBUCIÓN DE LOS SEROTIPOS. TIPIFICACIÓN MOLECULAR DE LOS CLONES DE S. PNEUMONIAE . ISCIII INSTITUTO DE SALUD CARLOS III . REF. PI060647
EPIDEMIOLOGÍA DE LA RESISTENCIA A MACRÓLIDOS DE STREPTOCOCCUS PNEUMONIAE EN PACIENTES ADULTOS CON ENFERMEDAD NEUMOCÓCICA INVASIVA. . FIS . REF. PI020269
PROYECTOS COORDINADOS EN EPIDEMIOLOGÍA, INVESTIGACIÓN BÁSICA Y CLÍNICA DE LA RED DE INVESTIGACIÓN EN SIDA (RIS) PARA EL AÑO 2006 . MINISTERIO DE SALUD Y CONSUMO . REF. PI052669
UTILIDAD DE LA DETECCIÓN DE GAMMA-INTERFERÓN IN VITRO PARA EL DIAGNÓSTICO DE TUBERCULOSA EN PACIENTES INFECTADOS POR EL VIRUS DE LA INMUNODEFICIENCIA HUMANA TIPO 1 . FUNDACIÓN PARA LA INVESTIGACIÓN Y PREVENCIÓN DEL SIDA EN ESPAÑA (FIPSE) . REF. 24589/06

The objective of investigation of this group is centered on studies regarding the prediction of the efficacy and safety of drugs through genetic analysis. Specificially, projects on genetics which may condition the toxicity of antipsychotic drugs and drugs which act on the cardiovascular system are performed. In addition, the development of new genotyping methodologies are investigated for their clinical application.

Projects financed:

LOS POLIFENOLES EN LA PREVENCIÓN DE LA ATEROSCLEROSIS. MECANISMOS MOLECULARES IMPLICADOS EN EL ESTRÉS OXIDATIVO E INFLAMACIÓN PARA EXPLICAR LA PARADOJA FRANCESA. FIS. INSTITUTO NACIONAL DE LA SALUD . REF. PI052629
HIPERSENSIBILIDAD PULMONAR (TOS SECA) POR TRATAMIENTO CON IECAS. SU POSIBLE PREDICCIÓN A TREVÉS DEL ESTUDIO DE LOS POLIMORFISMOS GENÉTICOS EN ECA, Y EN LOS GENES EL RECEPTOR DE LA BRADIQUININA Y DE LA QUIMASA FIS - INSTITUTO DE SALUD CARLOS III- MINISTERIO DE SANIDAD Y CONSUMO . REF. EC07/90239
PROTEOMICA DEL ESPERMATOZOIDE EN PACIENTES INFERTILES, EN MODELOS KNOCK OUT Y MECANISMO DE LA TRANSICIÓN NUCLEOHISTONA-NUCLEOPROTAMINA MINISTERIO DE CIENCIA Y TECNOLOGÍA . REF. BFU2006-03479

The objectives of investigation of this group are: - Development and registration of medications in the European Union. - Investigation in the procedures of clinical analysis: Phases, Design, Monitoring and Analysis. - Analysis of the procedures of the European networks and the Spanish Agency of Medications and Health Care Products. - Analysis of the studies of drug surveillance and pharmacoepidemiology.

Projects financed:

ESTUDIO DE UTILIZACIÓN DE ANTIFÚNGICOS SISTÉMICOS EN LOS HOSPITALES ESPAÑOLES INSTITUTO DE SALUD CARLOS III . REF. EC07/90444
EUROPEAN CLINICAL RESEARCH INFRASTRUCTURES NETWORK? (ECRIN) 7º PROGRAMA-MARCO DE LA UNIÓN EUROPEA . REF. FP7-INFERA-STRUCTURES-2007-1 (INFRA-2007-2,2,1-18)

The group focused its research in the prospection and preventable risk factors in malignance and the sistemic repercutions of drugs used in chemotherapy and anti-angiogenic therapeutics in solid tumours.

Projects financed:

IDENTIFICACIÓN DE NUEVAS DIANAS TERAPÉUTICAS EN TUMORES GERMINALES REFRACTARIOS FUNDACIÓN DE LA MARATÓN DE TV3 . REF. 51431

The group focused the research lines in clinical and biological consequenses of optic ways affectations and intrinsec ocular motility. Furthermore, study retinopathies as complication of these manifestations with a variety of diagnostic and therapeutic techniques.

Projects financed:

ENSAYO CLÍNICO MULTICÉNTRICO EN FASE III, RONDOMIZADO, DOBLE-CIEGO, CONTROLADO FRENTE A PLACEBO, DE REBIF (44MICROGR TRES VECES A LA SEMANA Y 44MICROGR UNA VEZ A LA SEMANA) EN PACIENTES CON ALTO RIESGO DE CONVERSIÓN DE ESCLEROSIS MÚLTIPLES. LAB. MERCK SERONO INTERNACIONAL . REF. CT:2006-002982-38

The objectives of the group and the lines of research are: - The physiopathology of the bone, pathologic variations with age, evaluation of fracture fixation techniques and bone replacement. - Cartilage degeneration and repair with tissue engineering. - Evaluation and design of new prosthetic implants. Minimally invasive surgery with new technology and tools. Infections of the locomotor apparatus, their prophylaxis and treatment. - Repariment for tubilization of lesions of the peripheral nervous system and experimental implantation of preganglion nerve roots. - Acute postsurgical and muscle-skeletal pain. - Biology of autologous adipose tissue grafts and muscle-skeletal system tissue bank. - Acute phase response in open fractures. The utility of IL-6, CRP and CK in the prediction of results and the correlation with the Gustilo classification.

Projects financed:

ANALISIS DE LAS CARACTERISTICAS Y LOS RESULTADOS DE LAS ARTROPLASTIAS DE CADERA Y RODILLA: DESARROLLO DE INSTRUMENTOS PARA LA EVALUACION DE LA PRACTICA FIS - INSTITUTO DE SALUD CARLOS III - MINISTERIO DE SANIDAD Y CONSUMO . REF. FISS PIO52850

Group of lines of investigation based on two experimental models which have demonstrated their utility in clinical application such as stopped heart donor using extracorporeal circulation and the porcine liver transplant model after cuasi-total hepatectomy. Both models allow the study of ischaemia-reperfusion lesions and the factors which may avoid the types of lesions inherent to transplantation.The SFS model is also useful for the study of hepatic regeneration mechanisms.

Projects financed:

Group of lines of investigation which have allowed the definition of the optimum criteria for indicating radical treatment of hepatic tumours, including hepatic resection and cadaveric or living donor liver transplantation. From these treatments two sublines of research have been derived aimed at the study of the natural history of the patients undergoing surgery for hepatic metastasis of colorectal origin. New markers which may predict the extension of the disease and the risk of recurrence are under study to thereby guarantee the best selection of patients for surgical treatment: NGAL (Neutrophil gelatinase-associated lipocalin) and proteomic markers.

Projects financed:

The objectives and lines of investigation are centered on establishing the prognostic factors and risk profiles of occular diseases: macular degeneration associated with age and glaucoma; genetic inflammatory polymorphisms in uveitis, genetic factors associated with diabetic macular disease and immunological factors associated with cornea transplantation rejection. Cell therapy and regenerative medicine applied to the occular surface.

Projects financed:

MECANISMOS CELULARES Y MOLECULARES IMPLICADOS EN LA REPARACION Y LA REGENERACION DE LA SUPERFICIE OCULAR:POTENCIAL TERAPEUTICA DE LAS CELULAS PROGENITORAS DEL ADULTO FIS,INSTITUTO DE SALUD CARLOS III . REF. PI051245
MECANISMOS CELULARES Y MOLECULARES IMPLICADOS EN LA REPARACION Y LA REGENERACION DE LA SUPERFICIE OCULAR:POTENCIAL TERAPEUTICA DE LAS CELULAS PROGENITORAS DEL ADULTO FIS,INSTITUTO DE SALUD CARLOS III . REF. PI051016/2005
ANÁLISIS DE LAS BASES MOLECULARES RESPONSABLES DE LAS ENFERMEDADES AUTOINFLAMATORIAS SISTÉMICAS NO FILIADAS: DESARROLLO Y VALIDACIÓN DE PRUEBAS DIAGNÓSTICAS E IDENTIFICACIÓN DE POTENCIALES DIANAS PARA TERAPIAS BIOLÓGICAS INMUNOMODULADORAS. FIS . REF. PI06241

Group of national and international projects addressed to the clinical evaluation and development of different endovascular devices applicable in the pathology of the thoracic and abdominal aorta. These include prospective and retrospective analyses of cost-efficacy, safety and efficacy of new generation endoprostheses used for emergency and elective treatment of aneurysms, dissections, traumatisms, penetrating ulcers, inramural haematomas and other pathologies of the aorta. Likewise, programmes of hybrid and combined surgery are performed (endovascular and revascularization of the aortic branches) in the treatment of complex thoracic, abdominal and thoraco-abdominal aortic disease. Other studies are aimed at the evaluation and development of imaging techinques and monitoring for the diagnosis, planning, performance and follow up of aortic endovascular procedures.

Projects financed:

Group of projects aimed at the evaluation of new therapeutic resources of ischemia of the lower limbs which include prospective clinical analysis studies of new endovasclar devices (non-impregnated stents, impregnated stents, pharmacoactive stents...) and tubular prostheses (new materials, association with drugs, antiproliferatives,...) safety and efficacy of cellular and genetic therapy in non revascularizable cases, evaluation of adjuvant drugs to conventional vascular and endovascular surgery, the evaluation of new haemostasis induction products. Moreover, complementary experimental studies have been incorporated in collaboration with the MIT (Massachusetts Institute of Technology) and Harvard - MIT Biomedical Engineering Center, for the evaluation of the biofunctional impact of stents on the arterial endothelium (in vitro and animal models).

Projects financed:

This includes a group of experimental and clinical lines of investigation covering the scientific field of organ, tissue and cell donation and related aspects. The main objectives of investigation are: - Identification of the donor and clincial and experimental criteria of organ viability. - Investigation in the diagnosis of brain death. - Clinical and experimental investigation of the maintenance of organ donors. - Family consent and psychosocial aspects. - Multiorgan extraction and methods of preservation and organ perfusion. - Investigation of the criteria and viability of the different types of donors: Live donor, stopped heart donor, domino donor, tissue donor. - Investigation in tissue and cell donation and transplantation: Bank of occular tissue, muscle-skeletal, cardiovascular, cutaneous, amniotic membrane, stem cells, tissue for investigation and teaching. - Investigation in the formation of transplant coordinators.

Projects financed:

EUROPEAN LIVING DONATION AND PUBLIC HEALTH (EULID) PUBLIC HEALTH EXECUTIVE AGENCY (PHEA) . REF. Agreement Number 2006211

This group includes many disciplines (Surgery, Pancreas Transplantation, Gastroenterology, Endoscopy, Radiology, Anatopathology, Oncology, Radiotherapy,Investigation) working in coordination in the study of diseases of the pancreas. The activity of this group is developed in the Hospital Clinic which has sufficient structure for clinical and experimental investigation in these lines of research; the main lines of which are: -Innovative pancreatic surgery, reconstruction techniques following duodeno-pancreatectomy, Conservative surgery of the pancreas, minimally invasive pancreas surgery. - Adjuvant therapy in cancer of the pancreas. - The importance of radiologic diagnosis in the selection of patients for surgical treatment of pancreatic

Projects financed:

MEJORA DE LA EFICACIA DE LA GEMCITABINA EN EL TRATAMIENTO DEL CÁNCER PANCREÁTICO A TRAVÉS DE LA MANIPULACIÓN DE GENES IMPLICADOS EN LA RESISTENCIA A LA DROGA INSERM . REF. IN2005/2007
TRASPLANTE HEPÁTICO EXPERIMENTAL EN CERDOS. VIABILIDAD DEL INJERTO. DONACIÓN A CORAZÓN PARADO BECA FIS . REF. 98-1247,Enero 1998
TECNICAS DE ENDOSCOPIA AVANZADA PARA LA OPTIMIZACION DEL MANEJO DE LOS PACIENTES CON ENFERMEDADES COLORECTALES INSTITUTO DE SALUD CARLOS III . REF. PI07/90174
EFECTOS LOCALES Y SISTÉMICOS PROVOCADOS POR LA GENERACIÓN DE ISOPROSTANOS EN LA PANCREATITIS AGUDA. FIS . REF. PI 040708

Group of lines of clinical and experimental investigation regarding to anaestesiology and related aspects: a) pharmacodynamics and pharmacokinetics of the different anaesthesic agents; b) Experimental and clinical investigation on the improvement in survival following cardio-respiratory arrest; c) Experimental and clinical investigation in the field of pain, the devleopment and prevention of neuropathic and acute postoperative pain. Psychological and familial therapy aspects in chronic pain and medullar neurostimulation; d) Clinical and experimental investigation on the viability of transplanted kidney and liver organs of donors with brain death and stopped heart; e) Detection and treatment of splanchnic, cerebral and pulmonary tissue ischaemia-reperfusion; f) Acute cerebral disease and sepsis in the critical patient and factors of survival in mechanical ventilation; g) Anatomical and physiological factors related to nerve blockade; h) Multicentre epidemiological investigation on perioperative morbi-mortality; i) Airway management during anaesthesic procedures and quality control.

Projects financed:

ESTUDIO DEL RIESGO DE COMPLICACIONES RESPIRATORIAS POSTOPERATORIAS Y RECUPERACIÓN FUNCIONAL A LOS 3 MESES EN PACIENTES FUMADORES. MARATO TV3 . REF. 041610

The lines of research are based on clinical and biological studies focused in the fisiopathology of the main syndromes in critically-ill patients and emergencies. In addition, there is research in clinical management and ethics.

Projects financed:

DEFENSINAS Y GEN APOBEC3G (CEM15), NUEVAS MOLÉCULAS CANDIDATAS COMO FACTORES DEL HUÉSPED DE RESISTENCIA INNATA CONTRA LA INFECCIÓN POR EL VIH Y SU PROGRESIÓN HACIA SIDA FISS . REF. PI031200

The aim of research of the group is based on clinical and biological studies that evaluate the fisiopathology on the main syndroms related to aging.

Projects financed:

EVALUACIÓN DEL ESTADO FUNCIONAL Y CALIDAD DE VIDA A LARGO PLAZO EN PACIENTES GERIÁTRICOS INGRESADOS EN UNA UNIDAD DE CUIDADOS INTENSIVOS INSTITUTO DE INVESTIGACIÓN CARLOS III . REF. FISS 2003/0329

The investigation by this group is centred on the following lines: - indications and limitation of imaging techinques in different clinical settings: diagnostic performance and efficacy. ¿ Diagnostic algorithms from clinical syndromes. ¿ Intervention procedures guided by imaging techniques: technique of action, indications, performance and complications. ¿ Therapeutic possibilities through imaging techniques: techniques of action, indications, performance and complications.

Projects financed:

This group is focused on lines of investigation in which projects related to surgically-approached anatomy (locomotor, plastic, and reconstructive surgery and neurosurgery), experimental and quantitative neuroanatomy (peripheral nerve regeneration, neuroimaging) and virtual and simulation surgery are developed.

Projects financed:

ANÁLISIS DEL VALOR DIAGNÓSTICO Y PRONÓSTICO DE LA TRACTOGRAFÍA EN EL INFARTO CEREBRAL AGUDO FIS . REF. PI060745

The aim of research is the physiopathology of foetal alterations are analysed, especially malformations and growth retardation, at both a clinical and experimental level (models in rats and rabbits). Neurological and biochemical problems are also included, particularly those linked to congenital metabolic diseases and other problems related to different paediatric subspecialties such as endocrinology, cardiology, etc.

Projects financed:

ALTERACIONES INMUNOLÓGICAS TRAS LA INFECCIÓN POR VIRUS RESPIRATORIO SINCITIAL ,QUE INDUCEN LA APARICIÓN DE ASMA EN EL NIÑO SOCIEDAD ESPAÑOLA DE INMUNOLOGÍA Y ALERGIA. /FUNDACIÓN SANT JOAN DE DÉU . REF.
DESARROLLO VASCULAR Y MADURACIÓN PULMONAR EN UN MODELO DE HERNIA DIAFRAGMÁTICA EN FETO DE CONEJO. EFECTO DE LA OCLUSIÓN TRAQUEAL FETAL FONDO DE INVESTIGACIÓN SANITARIA. . REF. 06/0585

The investigation of this group covers the following lines: - Analysis of polymorphisms (SNPs) in samples of patients with neoplasms with the aim to determine the genetic profiles which are most adequate for antitumoural treatment. ¿ Analysis of microRNAs (miRNAs) in human embryonic and tumoural samples to detect common markers and mechanisms among the initial organogenesis and tumoural phases.

Projects financed:

The objectives of investigation of this group include: - The study of the use of the effects of medications in different populations or consumption studies and the effects of medications in the community. - Studies on the use of medications related to the commercialization, distribution and use of drugs in a society with special emphasis on the resulting medical, social and economic consequences. - Studies on drug surveillance which analyse the impact of undesired effects produced by medications in clinical practice. - Analysis of the transfer of results of investigation in clincial practice such as measurement of the impact of the publication of clinical trials on prescription habits.

Projects financed:

EFECTIVIDAD, ADECUACIÓN Y SEGURIDAD DE LOS MEDICAMENTOS BIOTECNOLÓGICOS EN EL TRATAMIENTO DE LOS PACIENTES CON ARTRITIS REUMATOIDE? AGENCIA DE EVALUACIÓN DE TECNOLOGÍAS E INVESTIGACIONES MÉDICAS DE CATALUÑA AATRM- . REF. 053/02/2006
ESTUDIO DE UTILIZACIÓN DE ANTIFÚNGICOS SISTÉMICOS EN LOS HOSPITALES ESPAÑOLES INSTITUTO DE SALUD CARLOS III . REF. EC07/90305

The objective of this group is to study health care education programmes and advice aimed at the population to improve the level of autonomy and improve the indicators of health (individual, group and new audiovisual technology interventions). In addition, the group evaluates these interventions and those including the implication of the patient in decision-making related to his/her health.

Projects financed:

EFECTIVIDAD DE UN INSTRUMENTO DE AYUDA A LA TOMA DE DECISIONES COMPARTIDA SOBRE EL RIESGO CARDIOVASCULAR EN PACIENTES FIS . REF. PI060413

The objective of this group is centred on the investigation of: - Vaccination programme coverage in different population groups in Catalunya and the study of the impact of the vaccination programmes in relation to the epidemiology of invasive pneumococcic disease. ¿ Factors associated with herpes zoster by observational analytical study of cases and controls.

Projects financed:

EVALUACIÓN DE LA EFECTIVIDAD DE LA VACUNA ANTINEUMOCÓCICA CONJUGADA 7 VALENTE EN LA PREVENCIÓN DE LA ENFERMEDAD NEUMÓCICA INVASORA EN NIÑOS MENORES DE 5 AÑOS. ESTUDIO DE CASOS Y CONTROLES. FIS . REF. PI 061507

This group constitutes part of the Department of Public Health with investigation being focused on the lines of analysis of health and health care service determinants as well as geographic epidemiology.

Proyectos financiados


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