Nutritional Cell Signalling
Department of Nutrition, Food Sciences and Gastronomy
Faculty of Pharmacy and Food Sciences, UB
Diego Haro Bautista
ORCID ID: 0000-0001-9147-0486
Tel +34 934934500
Pedro F. Marrero González
Tel +34 934034500
Principal investigator: • Diego Haro Bautista • Pedro F. Marrero González
Researchers: • Joana Relat Pardo
PhD students: • Viviana Paz Sandoval • Úrsula Monserrat Martínez Garza • Héctor Sanz Lamora
Current
Research
Our scientific trajectory has focused on the metabolic control of gene expression. We have found that dietary interventions regulate the expression and/or the signaling of Fgf21 in a tissue-specific manner. The relevance that this peptide hormone has taken in the field of obesity/diabetes, and its effects on browning, led us to study the role that nutritional interventions, such as low protein diet or polyphenols-supplemented diets, may have against the deleterious effect of a high fat diet (HFD).
We are currently interested in the search for dietary factors that impact gene expression in a beneficial way for the prevention of insulin resistance (IR) generated by an HFD. We are also interested in understanding how diet (or its components) can stimulate the process of browning in white adipose tissue.
Our objective is to determine the molecular mechanisms that, as consequence of the dietetic intervention, are responsible for the changes in the gene expression that leads to the metabolic adaptation in the different tissues
Selected
Publications
Sandoval, V.; Rodríguez-Rodríguez, R.; Martínez-Garza, Ú.; Rosell-Cardona, C.; Lamuela-Raventós, R. M.; Marrero, P. F.; Haro, D.; Relat, J. Mediterranean Tomato-Based Sofrito Sauce Improves Fibroblast Growth Factor 21 (FGF21) Signaling in White Adipose Tissue of Obese ZUCKER Rats. Molecular Nutrition Food Research. 62(4), 2018. doi.org/10.1002/mnfr.201700606
Pérez-Martí, A.; Garcia-Guasch, M.; Tresserra-Rimbau, A.; Carrilho-Do-Rosário, A.; Estruch, R.; Salas-Salvadó, J.; Martínez-González, M. Á.; Lamuela-Raventós, R.; Marrero, P. F; Haro, D.; Relat, J. A low-protein diet induces body weight loss and browning of subcutaneous white adipose tissue through enhanced expression of hepatic fibroblast growth factor 21 (FGF21). Molecular Nutrition Food Research. 61(8), 2017. doi.org/10.1002/mnfr.201600725
FGF21 mediates the lipid metabolism response to amino acid starvation. De Sousa-Coelho, A. L.; Relat, J.; Hondares, E.; Pérez-Martí, A.; Ribas, F.; Villarroya, F.; Marrero, P. F.; Haro, D. Journal of Lipid Research. 54(7):1786-97, 2013. doi.org/10.1194/jlr.M033415
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. Vilà-Brau, A.; De Sousa-Coelho, A. L.; Gonçalves, J. F.; Haro, D.; Marrero, P. F. Journal of Lipid Research. 54(3):592-601, 2013. doi.org/10.1194/jlr.M028472
De Sousa-Coelho, A. L.; Marrero, P. F.; Haro, D. Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation. Biochemical Journal. 2012 Apr 1;443(1):165-71. doi.org/10.1042/BJ20111748
