IBUB

Institut de Biomedicina de la Universitat de Barcelona

Drug and target discovery for biomedical science

The Institute of Biomedicine of the University of Barcelona (IBUB) is a transversal research unit formed by some 40 groups from the Faculties of Biology, Chemistry and Pharmacy and Food Sciences. The IBUB was created in 2006 with the aim of identifying, beyond the traditional academic structures (departments and faculties), a set of laboratories with complementary scientific activity, capable of generating synergies.

News

Technology Transfer Opportunities

One of the key strengths of IBUB is its ability to successfully transfer knowledge to society

Projects

314

Research groups

40

Publications

725

Research

The Institute of Biomedicine brings together highly qualified biomedical research personnel working in groups renowned for their excellence, and its founding collective’s indicators in scientific production and the raising of resources testify to the IBUB’s benchmark status in biomedical research in both Catalonia and the rest of Europe.

Research Programs

IBUB is comprised of research groups actively coordinated in the form of differents programs and nodes

Research Groups

IBUB consists of different specialized research groups

Seminars

Glucocorticoid and Androgen Receptors Oligomerization: a Jigsaw Puzzle

Eva Estébanez-Perpiñá, de l’Institut de Biomedicina de la Universitat de Barcelona (IBUB)

Date

December 2, 2024

Time

13:00h

Place

Aula Graus

Preclinical testing of personalized CRISPR therapies for Duchenne Muscular Dystrophy

Óscar Gutiérrez, Stem Cell Unit, Univ. Medical Center Göttingen

Date

October 31, 2024

Time

16:00h

Place

A14, Ed. Durfort, Fac. Biology

Cellular Senescence: Search and Destroy

Manuel Collado, CNB-CSIC, Universidade de Santiago de Compostela

Date

October 31, 2024

Time

15:30

Place

A14, Ed. Durfort, Fac. Biology

Article of the month

Edurne Urquizu, Selma Paratusic, Júlia Goyenechea, Cristian Gómez-Canela, Berta Fumàs, David Pubill, Demetrio Raldúa, Jordi Camarasa, Elena Escubedo, Raúl López-Arnau

International Journal of Molecular Sciences

Acute Paraoxon-Induced Neurotoxicity in a Mouse Survival Model: Oxidative Stress, Dopaminergic System Alterations and Memory Deficits

The secondary neurotoxicity induced by severe organophosphorus (OP) poisoning, including paraoxon (POX), is associated with cognitive impairments in survivors, who, despite receiving appropriate emergency treatments, may still experience lasting neurological deficits. Thus, the present study provides a survival mouse model of acute and severe POX poisoning to examine secondary neurotoxicity. Swiss CD-1 male mice were injected with POX (4 mg/kg, s.c.) followed by atropine (4 mg/kg, i.p.), pralidoxime (2-PAM; Pyridine-2-aldoxime methochloride) (25 mg/kg, i.p., twice, 1 h apart) and diazepam (5 mg/kg, i.p.), resulting in a survival rate >90% and Racine score of 5–6. Our results demonstrated that the model showed increased lipid peroxidation, downregulation of antioxidant enzymes and astrogliosis in the mouse hippocampus (HP) and prefrontal cortex (PFC), brain areas involved in cognitive functions. Moreover, dopamine (DA) levels were reduced in the hp, but increased in the PFC. Furthermore, the survival mouse model of acute POX intoxication did not exhibit phenotypic manifestations of depression, anxiety or motor incoordination. However, our results demonstrated long-term recognition memory impairments, which are in accordance with the molecular and neurochemical effects observed. In conclusion, this mouse model can aid in researching POX exposure’s effects on memory and developing potential countermeasures against the secondary neurotoxicity induced by severe OP poisoning.

Announcements

MCP Lab offers a predoctoral contract associated with a project of the AGAUR Program “Indústria del Coneixement”

Data límit

20/1/2024 - Send CV and motivation letter

ENDED- Call for 6 research initiation grants 2023-2024

Data límit

3 d'octubre 2023. Més informació: https://www.ub.edu/ibub/call-for-6-research-initiation-grants-2023-2024/ Convocatòria: https://seu.ub.edu/ajutsPublic/showPublicacion/441657

Contact

Institut de Biomedicina de la Universitat de Barcelona, IBUB

Departament de Bioquímica i Biomedicina Molecular

Facultat de Biologia / Secretaria IBUB & Bioinformàtica
Avda. Diagonal, 643
Edifici Prevosti, planta -1
08028 Barcelona

+34 606 14 87 72
ibub@ub.edu

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