Currently working Directorof Analytical and Therapeutic Development | Infertility & Reproductive Health, in Gameto and Harvard Medical School.
Recent publicactions:
Paulsen B*, Piechota S*, Barrachina F*, et al. Rescue in vitro maturation using ovarian support cells of human oocytes from conventional stimulation cycles yields oocytes with improved nuclear maturation and transcriptomic resemblance to in vivo matured oocytes. Journal of Assisted Reproduction and Genetics (In Press) 2024. *Equal contribution
Marchante M, Barrachina F, et al. Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF) treatment. 2024, medRxiv. DOI: 10.1101/2024.03.28.24304995
Marchante M*, Barrachina F*, et al. Ovarian support cell in vitro maturation (OSC-IVM) results in healthy murine live births with no evidence of reprotoxicology in a multigenerational study. 2024, BioRxiv. DOI: 10.1101/2024.04.04.588122 *Equal contribution.
Paulsen B, Barrachina F, et al. Reproducible differentiation of pure ovarian support cells from clinical-grade hiPSCs as a novel infertility treatment. 2024, BioRxiv. DOI: 10.1101/2024.04.29.591741
Piechota S, et al. Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation in vitro after abbreviated gonadotropin stimulation. Human Reproduction, 2023, dead205
Publications
9: de la Iglesia A, Jauregi P, Jodar M, Barrachina F, Ded L, Mallofré C, Rodríguez-Carunchio L, Corral JM, Ballescà JL, Komrskova K, Castillo J, Oliva R.
H4K5 butyrylation coexist with acetylation during human spermiogenesis and are retained in the mature sperm chroma-tin.
Int J Mol Sci 2022;23:12398.
8: Grande G, Barrachina F, Soler-Ventura A, Jodar M, Mancini F, Marana R, Chiloiro S, Pontecorvi A, Oliva R, Milardi D.
The Role of Testosterone in Spermatogenesis: Lessons From Proteome Profiling of Human Spermatozoa in Testosterone Deficiency.
Front Endocrinol 2022;13:852661
7: Barrachina F, Battistone MA, Castillo J, Mallofré C, Jodar M, Breton S, Oliva R.
Sperm acquire epididymis-derived proteins through epididymosomes.
Hum Reprod. 2022; 37:651-668
6: Arato I, Grande G, Barrachina F, Bellucci C, Lilli C, Jodar M, Aglietti MC, Mancini F, Vincenzoni F, Pontecorvi A, Calafiore R, Oliva R, Luca G, Mancuso F, Milardi D.
" In vitro" Effect of Different Follicle-Stimulating Hormone Preparations on Sertoli Cells: Toward a Personalized Treatment for Male Infertility.
Front Endocrinol (Lausanne). 2020 Jun 18;11:401
5: Jodar M, Attardo-Parrinello C, Soler-Ventura A, Barrachina F, Delgado-Dueñas D, Cívico S, Calafell JM, Ballescà JL, Oliva R.
Sperm proteomic changes associated to early embryo quality after ICSI.
Reproductive Biomedicine Online. 2020; 40(5):700-710. doi: 10.1016/j.rbmo.2020.01.004
4: Grande G, Vincenzoni F, Mancini F, Barrachina F, Giampietro A, Castagnola M, Urbani A, Oliva R, Pontecorvi A, Milardi D.
Quantitative analysis of the seminal plasma proteome in secondary hypogonadism.
Journal of Clinical Medicine 2019, 8, 2128; doi:10.3390/jcm8122128
3: Barrachina F, Jodar M, Delgado-Dueñas D, Soler-Ventura A, Estanyol JM, Mallofré C, Ballesca JL, Oliva R.
Stable-protein Pair Analysis as A Novel Strategy to Identify Proteomic Signatures: Application To Seminal Plasma From Infertile Patients.
Mol Cell Proteomics. 2019 Mar 15;18(Suppl 1):S77-S90. doi: 10.1074/mcp.RA118.00124
2: Soler-Ventura A, Castillo J, de la Iglesia A, Jodar M, Barrachina F, Ballesca JL, Oliva R.
A Step-By-Step Protocol For Mammalian Sperm Protamine Extraction And Analysis.
Protein Pept Lett
1: Barrachina F, Anastasiadi D, Jodar M, Castillo J, Estanyol JM, Pifarrer F, Oliva R.
Identification of a complex population of chromatin-associated proteins in addition to protamines in the European sea bass (Dicentrarchus labrax) sperm.
Systems Biology in Reproductive Medicine 2018; 64:502-517