Academic Achievements
European PhD title (PhD with European Doctorate Mention) obtained 4th June 2010 with Excellent Cum Laude (maximum grade). PhD Programme: Biopathology in Medicine (University of Barcelona, Spain) Set 2005 - June 2010. Thesis title: Proteomic and molecular characterization of human spermatozoa in infertile patients and controls. Supervisor: Dr. Rafael Oliva. Location: Human Genetics Laboratory, Department of Physiological Sciences, Faculty of Medicine, University of Barcelona, Barcelona (Spain).
Degree in Biology (Set 2000- June 2005) speciality “Cellular Biology and Genetics” in the branch “Fundamental Biology” by the Autonomous University of Barcelona, Faculty of Science, Cerdanyola del Vallés (Spain).
Fellowships and Activities
Postdoctoral at Dr. Paolo Sassone-Corsi Laboratory in the University of California, Irvine ( Dr. Paolo Sassone-Corsi Laboratory, http://www.biochem.uci.edu/index.html).
Four years PhD Fellowship awarded from the Generalitat of Catalunya (Spain) called “Predoctoral fellowships for the formation of research staff (FI)” from 1st Jan 2006 to 31st Dec 2009. Additional Fellowship award received from the Generalitat de Catalunya for the PhD studies realized under FI fellowship (14th July 2010).
1st PhD short research stay fellowship (4 months, 21st Jan-20th May 2008). Short stay research fellowship abroad granted by the Generalitat de Catalunya (2007-BE2-00195). Four months in Radboud University Nijmegen Medical Centre (UMC), Department of Obstetrics and Gynaecology, Nijmegen, The Netherlands during 2008 under the supervision of Dr. Peter de Boer and Dr. Liliana Ramos. The results of the research work I did during this short stay have been published in the International Journal of Andrology (see in the list of publications below).
2nd PhD short research stay fellowship (2 months, 19th Oct - 18th Dec 2009). Short stay research fellowship abroad granted by the Generalitat de Catalunya (2009-BE1-00452). Two months in Georgetown University Medical Centre, Department of Biochemistry and Molecular & Cellular Biology, Washington DC, United States of America during 2009 under the supervision of Dr. Martin Dym.
Research interests
Previous:
- Proteomic characterization of the human spermatozoa by mass spectrometry. Description of proteomic differences in infertile samples compared to sperm donors.
- Human sperm nuclear isolation and proteome description.
- Chormatin quality analysis of human sperm cells selected through gradient centrifugation. Immunofluorescence detection of specific modified histones.
- Correlation between protamine content and assisted reproductive outcome.
Current:
- Metabolic and epigenetic analysis of the murine spermatogenic process.
Publications
12: de Mateo S, Estanyol JM, Oliva R.
Methods for the analysis of the sperm proteome.
Methods Mol Biol. 2013;927:411-22
11: de Mateo S, Castillo J, Estanyol JM, Ballescà JL, Oliva R.
Proteomic characterization of the human sperm nucleus.
Proteomics. 2011;11:2714-26.
10: de Mateo S, Ramos L, van der Vlag J, de Boer P, Oliva R.
Improvement in chromatin maturity of human spermatozoa selected through density gradient centrifugation.
Int J Androl. 2011;34:256-67.
9: Castillo J, Simon L, de Mateo S, Lewis S, Oliva R.
Protamine/DNA Ratios and DNA Damage in Native and Density Gradient Centrifuged Sperm From Infertile Patients.
J Androl. 2011;32:324-32.
8: de Mateo S, Ramos L, de Boer P, Meistrich M, Oliva R.
Protamine 2 Precursors and Processing.
Protein Pept Lett. 2011 Mar 28. [Epub ahead of print]Protamine 2 Precursors and Processing.de Mateo S, Ramos L, de Boer P, Meistrich M, Oliva R
7: Oliva R, De Mateo S, Castillo J, Azpiazu R, Oriola J, Ballescà JL.
Methodological advances in sperm proteomics.
Hum Fertil (Camb). 2010 Dec;13(4):263-7
6: de Mateo S, Gázquez C, Guimerà M, Balasch J, Meistrich ML, Ballescà JL, Oliva R.
Protamine 2 precursors (Pre-P2), protamine 1 to protamine 2 ratio (P1/P2), and assisted reproduction outcome.
Fertil Steril. 2009;91:715-22.
5: Oliva R, de Mateo S, Estanyol JM.
Sperm cell proteomics.
Proteomics. 2009 Feb;9(4):1004-17
4: Gázquez C, Oriola J, de Mateo S, Vidal-Taboada JM, Ballescà JL, Oliva R.
A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients.
J Androl. 2008 Sep-Oct;29(5):540-8.
3: Martínez-Heredia J, de Mateo S, Vidal-Taboada JM, Ballescà JL, Oliva R.
Identification of proteomic differences in asthenozoospermic sperm samples.
Hum Reprod. 2008 Apr;23(4):783-91.
2: de Mateo S, Martínez-Heredia J, Estanyol JM, Domínguez-Fandos D, Vidal-Taboada JM, Ballescà JL, Oliva R.
Marked correlations in protein expression identified by proteomic analysis of human spermatozoa.
Proteomics. 2007 Dec;7(23):4264-77
1: Oliva R, Martínez-Heredia J, de Mateo S, Gázquez C, Oriola J, Estanyol JM, Guimerà M, Balasch J, Ballescà JL.
Proteomics of human spermatozoa, protamine content and assisted reproduction outcome.
Soc Reprod Fertil Suppl. 2007;65:527-30