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Molecular Biology of Reproduction and Development

 

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José-Manuel Vidal-Taboada

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Dr. Vidal-Taboada obtained his PhD at our laboratory in 2000 with the Thesis entitled "Physiscal map construction and identification and characterization of genes in the chromosome 21 region associated to Down syndrome". From 2000-2006 was director of the Pharmacogenetic unit of the CRO RDES working in genetics and pharmacogenetics studies from Novartis Farmaceutica. From 2007-2008 was researcher at the CIMA (Centro Investigacion Medica Aplicada) from the University of Navarra. Presently he has a Professor position at the Biochemistry and Molecular Biology Unit, Faculty of Medicine, University of Barcelona. He is currently a Professor at the Biochemistry Unit of the Biomedicine Department of the Faculty of Medicine of the University of Barcelona.

Selected publications derived from his PhD thesis:

Genetic variation in APOE cluster region and Alzheimer's disease risk. Cervantes S, Samaranch L, Vidal-Taboada JM, Lamet I, Bullido MJ, Frank-García A, Coria F, Lleó A, Clarimón J, Lorenzo E, Alonso E, Sánchez-Juan P, Rodríguez-Rodríguez E, Combarros O, Rosich M, Vilella E, Pastor P. Neurobiol Aging. 2011 Nov;32(11):2107.e7-2107.e17.

Polymorphisms, haplotypes and mutations in the protamine 1 and 2 genes. Jodar M, Oriola J, Mestre G, Castillo J, Giwercman A, Vidal-Taboada JM, Ballescà JL, Oliva R. Int J Androl. 2010 Oct 1. doi: 10.1111/j.1365-2605.2010.01115.x.

Different MAPT haplotypes are associated with Parkinson's disease and progressive supranuclear palsy. Ezquerra M, Pastor P, Gaig C, Vidal-Taboada JM, Cruchaga C, Muñoz E, Martí MJ, Valldeoriola F, Aguilar M, Calopa M, Hernandez-Vara J, Tolosa E. Neurobiol Aging. 2011 Mar;32(3):547.e11-6.

5'-Upstream variants of CRHR1 and MAPT genes associated with age at onset in progressive supranuclear palsy and cortical basal degeneration. Cruchaga C, Vidal-Taboada JM, Ezquerra M, Lorenzo E, Martinez-Lage P, Blazquez M, Tolosa E; Iberian Atypical Parkinsonism Study Group Researchers, Pastor P. Neurobiol Dis. 2009 Feb;33(2):164-70.

SPG11 compound mutations in spastic paraparesis with thin corpus callosum. Samaranch L, Riverol M, Masdeu JC, Lorenzo E, Vidal-Taboada JM, Irigoyen J, Pastor MA, de Castro P, Pastor P. Neurology. 2008 Jul 29;71(5):332-6.

A common protamine 1 promoter polymorphism (-190 C->A) correlates with abnormal sperm morphology and increased protamine P1/P2 ratio in infertile patients. Gázquez C, Oriola J, de Mateo S, Vidal-Taboada JM, Ballescà JL, Oliva R. J Androl. 2008 Sep-Oct;29(5):540-8.

Human Proteinpedia enables sharing of human protein data. Mathivanan S, Ahmed M, Ahn NG, Alexandre H, …. Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A. Nat Biotechnol. 2008 Feb;26(2):164-7.


Publications

1: Alvarez-Palomo B, Barrot-Feixat C, Sarret H, Requena J, Pau M, Vidal-Taboada JM, Oliva R, Ballesca JL, Edel MJ, Mezquita-Pla J.
Two novel ligand-independent variants of the VEGFR-1 receptor are expressed in human testis and spermatozoa, one of them with the ability to activate SRC proto-oncogene tyrosine kinases.
Oncotarget 2019. Oct 8;10(56):5871-5887. doi: 10.18632/oncotarget.27232