Research Interests

The group is interested in the cellular and molecular mechanisms underlying secretion in neural and endocrine cells. These include studies on biogenesis, trafficking and exocytosis of secretory organelles and excitation-secretion coupling. 

We also study alterations of secretory processes in neurons and glial cells in Alzheimer’s disease, the mechanisms that sustain these disturbances and their pathological role. We combine multiple in-vitro, ex-vivo and in vivo approaches with biochemical and cellular and molecular biology techniques to analyse secretory pathways.

Moreover, the results of our research are expected to contribute to the identification of new biomarkers of neurodegenerative diseases.

Current Research Lines

1) Secretory pathways in neural and endocrine cells

2) Pathophysiology of Alzheimer’s disease

Current projects

2017-2019 Spanish Ministry of Science and Innovation BFU2016-80868-R ”New markers of Alzheimer's disease pathophysiology based on regulated secretory pathways” Scientist in charge: Fernando Aguado

2014-2016 Spanish Ministry of Science and Innovation BFU2013-48822-R “Alterations in the peptidergic secretory pathway of cortical and hypothalamic circuits in aging and Alzheimers disease” Scientist in charge: Fernando Aguado

2014-2016 Government of Catalonia SGR1178 “Physiology and pathology of the functional relationship between glia and neurons” Scientist in charge: Raúl Estévez