Publications

Selected Publications

  • Pérez-Hernández M, Cuscó C, Benítez-García C, Bonelli J, Nuevo-Fonoll M, Soriano A, Martínez-García D, Arias-Betancur A, García-Valverde M, Segura MF, Quesada R, Rocas J, Soto-Cerrato V, Pérez-Tomás R. Multi-Smart and Scalable Bioligands-Free Nanomedical Platform for Intratumorally Targeted Tambjamine Delivery, a Difficult to Administrate Highly Cytotoxic Drug. Biomedicines, 2021.
  • Carreira-Barral I, Mielczarek M, Alonso-Carrillo D, Capurro V, Soto-Cerrato V, Perez Tomas R, Caci E, Garcıa-Valverde M and Quesada R. Click-tambjamines as efficient and tunable bioactive anion transporters. ChemComm, 2020.
  • Pérez-Hernández M, Arias A, Martínez-García D, Pérez-Tomás R, Quesada R, Soto-Cerrato V. Targeting autophagy for cancer treatment and tumor chemosensitization. Cancers, 2019.
  • Martínez-García D, Pérez-Hernández M, Korrodi-Gregório L, Quesada R, Ramos R, Baixeras N, Pérez-Tomás R, Soto-Cerrato V. The natural-based antitumor compound T21 decreases survivin levels through potent STAT3 inhibition in lung cancer models. Biomolecules, 2019.
  • Martínez-García D, Manero-Rupérez N, Quesada R, Korrodi-Gregório L, Soto-Cerrato V. Therapeutic strategies involving survivin inhibition in cancer. Med Res Rev 2018.
  • Hernando E, Capurro V, Cossu C, Fiore M, García-Valverde M, Soto-Cerrato V, Pérez-Tomás R, Moran O, Zegarra-Moran O, Quesada R. Small molecule anionophores promote transmembrane anion permeation matching CFTR activity. Sci Rep 2018.
  • Jowett LA, Howe ENW, Soto-Cerrato V, Van Rossom W, Pérez-Tomás R, Gale PA. Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents. Sci Rep 2017. 
  • Kotev M, Manuel-Manresa P, Hernando E, Soto-Cerrato V, Orozco M, Quesada R, Pérez-Tomás R, Guallar V. Inhibition of Human Enhancer of Zeste Homolog 2 with Tambjamine Analogs. J Chem Inf Model. 2017
  • Manuel-Manresa P, Korrodi-Gregório L, Hernando E, Villanueva A, Martínez-García D, Rodilla AM, Ramos R, Fardilha M, Moya J, Quesada R, Soto-Cerrato V, Pérez-Tomás R. Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation. Mol Cancer Ther 2017, 16(7):1224-1235.
  • Rodilla AM, Korrodi-Gregório L, Hernando E, Manuel-Manresa P, Quesada R, Pérez-Tomás R and Soto-Cerrato V. Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and cell death in lung cancer. Biochemical Pharmacology 2017.
  • Korrodi-Gregório L, Soto-Cerrato V, Vitorino R, Fardilha M, Pérez-Tomás R. From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research. PLoS One 2016, 4;11(11):e0165973.
  • Wu X, Judd LW, Howe ENW, Withecombe AM, Soto-Cerrato V, Li H, Busschaert N, Valkenier H, Pérez-Tomás R, Sheppard DN, Jiang Y, Davis AP, and Gale PA. Nonprotonophoric  electrogenic Cl− transport mediated by valinomycin-like carriers. Chem 2016, 1 (1): 127-46.
  • Soto-Cerrato V, Manuel-Manresa P, Hernando E, Calabuig-Farinas S, Martinez-Romero A, Fernandez-Duenas V, Sahlholm K, Knopfel T, Garcia-Valverde M, Rodilla AM et al: Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane That Triggers Differentiation and Cell Death in Cancer Stem Cells. J Am Chem Soc 2015, 137(50):15892-15898.
  • Hernando E, Soto-Cerrato V, Cortes-Arroyo S, Perez-Tomas R, Quesada R: Transmembrane anion transport and cytotoxicity of synthetic tambjamine analogs. Org Biomol Chem 2014, 12(11):1771-1778.
  • Gale PA, Perez-Tomas R, Quesada R: Anion transporters and biological systems. Acc Chem Res 2013, 46(12):2801-2813.
  • Hosseini A, Espona-Fiedler M, Soto-Cerrato V, Quesada R, Perez-Tomas R, Guallar V: Molecular interactions of prodiginines with the BH3 domain of anti-apoptotic Bcl-2 family members. PLoS One 2013, 8(2):e57562.
  • Espona-Fiedler M, Soto-Cerrato V, Hosseini A, Lizcano JM, Guallar V, Quesada R, Gao T, Perez-Tomas R: Identification of dual mTORC1 and mTORC2 inhibitors in melanoma cells: prodigiosin vs. obatoclax. Biochem Pharmacol 2012, 83(4):489-496.
  • Perez-Tomas R, Vinas M: New insights on the antitumoral properties of prodiginines. Curr Med Chem 2010, 17(21):2222-2231.
  • Soto-Cerrato V, Vinals F, Lambert JR, Perez-Tomas R: The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor-beta receptor pathway. Biochem Pharmacol 2007, 74(9):1340-1349.
  • Soto-Cerrato V, Vinals F, Lambert JR, Kelly JA, Perez-Tomas R: Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells. Mol Cancer Ther 2007, 6(1):362-369.
  • Francisco R, Perez-Tomas R, Gimenez-Bonafe P, Soto-Cerrato V, Gimenez-Xavier P, Ambrosio S: Mechanisms of prodigiosin cytotoxicity in human neuroblastoma cell lines. Eur J Pharmacol 2007, 572(2-3):111-119.
  • Perez-Tomas R: Multidrug resistance: retrospect and prospects in anti-cancer drug treatment. Curr Med Chem 2006, 13(16):1859-1876.
  • Escobar-Diaz E, Lopez-Martin EM, Hernandez del Cerro M, Puig-Kroger A, Soto-Cerrato V, Montaner B, Giralt E, Garcia-Marco JA, Perez-Tomas R, Garcia-Pardo A: AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway. Leukemia 2005, 19(4):572-579.
  • Soto-Cerrato V, Llagostera E, Montaner B, Scheffer GL, Perez-Tomas R: Mitochondria-mediated apoptosis operating irrespective of multidrug resistance in breast cancer cells by the anticancer agent prodigiosin. Biochem Pharmacol 2004, 68(7):1345-1352.
  • Perez-Tomas R, Montaner B, Llagostera E, Soto-Cerrato V: The prodigiosins, proapoptotic drugs with anticancer properties. Biochem Pharmacol 2003, 66(8):1447-1452.

To view all publications:

ORCID ID Ricardo Pérez-Tomás: 0000-0003-3226-1240

ORCID ID Vanessa Soto-Cerrato: 0000-0001-5835-3595