Recent publication about novel photoswitching platinum compounds in Angewandte Chemie International Edition Journal in collaboration with Patrick Gamez group (University of Barcelona) was reported in Notícies Universitat de Barcelona (Link).
Title: Photoswitching the cytotoxic properties of platinum(II) compounds.
Authors: Presa A, Brissos RF, Caballero AB, Borilovic I, Korrodi-Gregório L, Pérez-Tomás R, Roubeau O, Gamez P
Abstract
The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of «photomodifying» a ligand coordinated to metal ions. Platinum(II) complexes from photoswitchable 1,2-dithienylethene-containing ligands have been prepared, which exhibit two interconvertible photoisomeric forms that present distinct DNA-interacting properties and cytotoxic behaviors.
