We will participate in a challenging project aimed at nanoencapsulating experimental and currently used chemotherapeutics for lung cancer treatment in collaboration with Ecopol Tech Company, which has been awarded a «Nuclis» Grant from the Catalonian Government.
We have recently published a compilation of therapeutic strategies that modulate autophagy for the treatment of cancer and tumor chemosensitization in Cancers Journal (Q1 Oncology). Title: Targeting Autophagy for Cancer Treatment and Tumor Chemosensitization Authors: Marta Pérez-Hernández, Alain Arias, David Martínez-García, Ricardo Pérez-Tomás, Roberto Quesada and Vanessa Soto-Cerrato. Abstract: Abstract: Autophagy is a tightly[…]
We have published a new paper in Biomolecules Journal elucidating the molecular mechanism by which an anticancer compound exerts survivin inhibition in different lung cancer models. Title: The Natural-Based Antitumor Compound T21 Decreases Survivin Levels through Potent STAT3 Inhibition in Lung Cancer Models Authors: David Martínez-García, Marta Pérez-Hernández, Luís Korrodi-Gregório, Roberto Quesada, Ricard Ramos,[…]
We have recently published, in Medicinal Research Reviews, a paper about survivin protein in cancer. In this review, therapeutic options targeting survivin for cancer treatment are analyzed. Direct survivin inhibitors and their current development status are explored. Moreover, the major signaling pathways implicated in survivin regulation are described and different therapeutic approaches involving survivin indirect inhibition are evaluated. Finally, promising novel[…]
We want to wellcome Dr. Marta Pérez-Hernández, who has recently joined the Cancer Cell Biology Group as a PostDoctoral researcher and has a strong background in both Cancer and Nanomedicine fields.
A new grant from the Spanish government has been awarded to PIs Dr. Ricardo Pérez-Tomás and Dr. Vanessa Soto-Cerrato for the therapeutic preclinical evaluation of new survivin inhibitors for cancer treatment.
We have participated in a work that describes the novel ability of small molecules anionophores to function as anion chanel protein surrogates with potential applications in the treatment of malignancies derived from the malfunction of natural anion transport mechanisms. Title: Small molecules anionophores promote transmembrane anion permeation matching CFTR activity Authors: Hernando E, Capurro V, Cossu[…]
Recent publication about cell responses induced by highly active indole-based tambjamine analogues treatment in lung cancer cells and its action over the apoptotic pathway. 2017 April 10 Title: Novel Indole-based Tambjamine-Analogues Induce Apoptotic Lung Cancer Cell Death through p38 Mitogen-Activated Protein Kinase Activation Authors: Manuel-Manresa P.; Korrodi-Gregório, L.; Hernando, E.; Villanueva, A.; Martínez-García, D.; Rodilla,[…]
Recent publication about the mitochondrial swelling and lysosomal disfunction triggered by synthetic tambjamine analogues and which lead to autophagy blockade and cell death in lung cancer in Biochemical Pharmacology. 2016 November 24 Title: Synthetic tambjamine analogues induce mitochondrial swelling and lysosomal dysfunction leading to autophagy blockade and cell death in lung cancer. Authors: Rodilla, A.M.;[…]
Recent publication about the functional profile of A549 and SW900 in PLoS One. 2016 November 4 Title: From Proteomic Analysis to Potential Therapeutic Targets: Functional Profile of Two Lung Cancer Cell Lines, A549 and SW900, Widely Studied in Pre-Clinical Research. Authors: Korrodi-Gregório L, Soto-Cerrato V, Vitorino R, Fardilha M, Pérez-Tomás R Abstract Lung cancer is[…]