Pilar Manuel Manresa studied Biotechnology at the Universitat de Lleida (Lleida, Spain). She obtained a Master degree on Pharmacology from the Universitat Autónoma de Barcelona in 2012. She joined our lab in November 2012 and is now performing her Ph.D. under the supervision of Dr. Ricardo Pérez-Tomás and Dr. Vanessa Soto-Cerrato.
Her work is focused on the study of the cytotoxic effect and characterization of the mechanism of action of novel anti-cancer drugs.
Main goals included in the thesis
- Identification of most cytotoxic tambjamine analog ionophores.
- Characterization of the anticancer effect of selected compounds.
- Study of their effect on intracellular pH (pHi). Qualitative and quantitative analysis of pHi variations.
- Proteomic and transcriptomic analysis. Mechanism of action and identification of key target proteins.
- Effect on in vivo studies (safety and efficiency of the selected compound).
- Evaluation of cytotoxic properties of selected compounds in primary cultures and cancer stem cells (CSC) derived from human lung tumors.
Selected Publications
- Facilitated Anion Transport Induces Hyperpolarization of the Cell Membrane that Triggers Differentiation and Cell Death in Cancer Stem Cells. Soto-Cerrato, V.; Manuel-Manresa, P.; Hernando, E.; Calabuig-Fariñas, S.; Martínez-Romero, A.; Fernández-Dueñas, V.; Sahlholm, K.; Knöpfel, T.; García-Valverde, M.; Rodilla, AM.; Jantus-Lewintre, J.; Farràs, R.; Ciruela, F.; Pérez-Tomás R.; Quesada R. Journal of American Chemical Society. 137 – 50, pp. 15892-8. 2016. ISSN 002-7863
