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Translational Microenvironment Research in Lung Cancer and
Lung Fibrosis Research interests overview
Tissue cells are social organisms
that tune their behavior based on a continuous exchange of biochemical and biophysical information
with their surrounding microenvironment, which includes neighbor cells,
extracellular matrix components and soluble factors. Normal
cell-microenvironment interactions are essential for the maintenance of
tissue structure and function. Conversely, cell-microenvironment interactions
become awry in many diseases such as cancer and fibrosis, leadign to a
permanent loss of tissue structure and function, and too often to the death
of the individual. We study how does the microenvironment control cell
behavior and misbehavior in normal and diseased conditions, particularly in
lung cancer and fibrosis. For this purpose, we use the state-of-the-art of cell
biology, bioengineering and
biophysical tools as well as our unique collection of cells derived from
patients with lung cancer or lung fibrosis. We then apply these tools to
study quantitatively the aberrant interactions between tissue cells -including
epithelial cells, fibroblasts, endothelial cells and immune cells- and their
microenvironment in these diseases. Our ultimate goal is to be translational by using our
understanding of how cell-microenvironment interactions contribute to cancer
and fibrosis to define new therapeutic strategies against these devastating
diseases as well as to identify novel biomarkers. For this purpose, we work
in close collaboration with clinical groups, and often with companies by
using our know-how and preclinical models.
For more specifics about our past and
current research, please browse the different
sections below:
[LAB MEMBERS] [RESEARCH] [PUBLICATIONS] [COLLABORATION
WITH INDUSTRY]
[NEWS&VIEWS] [COLLABORATORS] [OPENINGS] [TEACHING] [CONTACT] [SUPORT LUNG CANCER RESEARCH / DONAR
SUPORT RECERCA CÀNCER DE PULMÓ]
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Jordi Alcaraz
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Brief CV · Citizenship: Spain · Education: - Ph.D. in Biophysics,
University of Barcelona, Barcelona (Spain) 2002 - M. Sc. in Cell Physiology,
University of Barcelona, Barcelona (Spain) 2000 - B. Sc. in Physics,
University of Barcelona, Barcelona (Spain) 1997 · Biosketch: Jordi is a Serra-Húnter Associate
Professor in the School of Medicine at the University of Barcelona (UB) since
2016. He graduated in Physics in 1997 at the UB, and attended graduate school
at the same university, where he obtained his Ph.D. in the fields of Cellular
Biophysics and Nanobioengineering in 2002. From 2002 until 2007 he was a
joint postdoc between the Cancer Biology Laboratory of Dr
Mina J Bissell at the Lawrence Berkeley National Laboratory and the
Single Molecule Biophysics Laboratory of Prof
Carlos Bustamante at UC Berkeley. During his postdoc he pursued research
aiming to understand how biophysical cues from the tissue microenvironment
control differentiation and cancer progression at the single cell level. |
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Office Ph: (+34) 934031148 Lab Ph: (+34) 934039764 Fax: (+34) 934035278 Address: Unitat de Biofísica i Bioenginyeria Facultat de Medicina
Universitat de Barcelona Casanova 143 08036 Barcelona, Spain |
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Graduate students
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Paula Duch |
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Brief CV · Citizenship: Spain · Education: - M. Sc. in Integrative
Physiology, University of Barcelona, Barcelona (Spain) 2015 - B. Sc. in Biochemistry, Universitat
Autònoma de Barcelona, Barcelona (Spain), 2014
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Alejandro Llorente |
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Brief CV · Citizenship: Spain · Education: - M. Sc. in Biomedicine,
University of Barcelona, Barcelona (Spain) 2020 - B. Sc. in Biology, University
of Girona, Girona (Spain), 2019 - B. Sc. in Biotechnology, University
of Girona, Girona (Spain), 2019
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Elba Marín |
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Brief CV · Citizenship: Spain · Education: - M. Sc. in Translational
Medicine, University of Barcelona, Barcelona (Spain) 2018 - B. Sc. in Biomedical
Sciences, , University of Barcelona, Barcelona (Spain) 2017
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Postdoctoral Researchers |
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Marta Gabasa |
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Brief CV · Citizenship: Spain · Education: - PhD in Biology, University
of Barcelona, Barcelona (Spain) 2015
- M. Sc. in Biomedicine,
University of Barcelona, Barcelona (Spain) 2010 - B. Sc. in Biology,
University of Barcelona, Barcelona (Spain) 2008 |
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Natalia Díaz |
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Brief CV · Citizenship: Chile/Spain · Education: - PhD in Biochemistry, Universidad
de Chile, Santiago (Chile) 2016 - M. Sc. in Biochemistry, Pontificia
Universidad Católica de Valparaíso, Valparaíso (Chile) 2010 - B. Sc. In Science, Pontificia
Universidad Católica de Valparaíso, Valparaíso (Chile) 2007 |
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Rafael Ikemori |
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Brief CV · Citizenship: Brazil · Education: - PhD in Sciences, Universidade
de São Paulo, USP, Sao Paulo (Brazil) 2014 - M. Sc. in Genetics and
Molecular Biology, Univ. Estadual de Campinas, Campinas, (Brazil) 2009 - B. Sc. in Biological
Sciences, Univ. Estadual de Campinas, Campinas, (Brazil) 2006 |
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Marselina Arshekyan |
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Brief CV · Citizenship: Armenia · Education: - PhD in Biochemical and Pharmacological
Methodologies, University of Urbino Carlo Bo, Urbino (Italy) 2015 - B. Sc. in Pharmaceutical
Chemistry, Yerevan State University, Yerevan (Armenia) 2004 |
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RESEARCH
Current research projects and long-term research interests
Aberrant cancer-stroma interactions
in lung cancer Lung cancer remains the leading cause of cancer-related
deaths worldwide, with a 5-year survival rate of only 18% that is much lower
than other leading cancer types like breast (89%) or colon (65%). Lung tumors
and other solid neoplasias are increasingly regarded as organs driven by the
aberrant co-evolution of cancer and stromal cells. Based on the striking
similarities between the stroma in tumors and wounds, tumors are often
described as “wounds that never heal”,
and the desmoplastic (wound-like) stroma is pointed as a major contributor to
tumor progression and even resistance to therapies. However, the mechanisms
underlying the effects of such tumor stroma on tumor-promotion and modulation
of therapy responses remain poorly understood, particularly in lung cancer.
To address this limitation, we started in 2010 a collection of tumor
associated fibroblasts (TAFs) -the most abundant stromal cell type- from
surgical patients of the Hospital Clínic de Barcelona diagnosed with
non-small cell lung cancer (NSCLC), which is the most abundant lung cancer
type. We use advanced pre-clinical
culture models to study the aberrant cancer-fibroblast interactions in
lung cancer to unveil key molecular alterations that can be useful to develop
novel therapies, to identify novel biomarkers and to dissect the mode of action of therapies. Role of abnormal tissue mechanics in
fibrosis and cancer It is well known that each tissue and organ in our body is
characterized by a specific deformability or “stiffness”. Thus, our brain or
lungs are soft organs, whereas our muscle and bones are stiff. In normal
conditions, the stiffness of each tissue is maintained within its
physiological range during adulthood. Occasionally, a region of a tissue may
temporarily stiffen as part of the normal wound healing response to damage. Likewise, tissue stiffness
becomes progressively altered during aging.
None of these previously mentioned mechanical alterations compromise neither
the integrity nor the normal function of the tissue. In contrast, a hallmark
of numerous diseases is the permanent loss of normal tissue stiffness,
concomitantly with an impairment of normal functions. In some cases, the
tissue becomes abnormally soft as
in arthritis, emphysema or osteoporosis. In other cases, the
tissue becomes abnormally stiff as
in sclerosis, fibrosis and cancer.
We are particularly interested in how normal tissue stiffness is lost in
fibrosis and cancer, and how this abnormal tissue hardening contributes to
the progression of these devastating diseases. Moreover, we are interested in
using tissue mechanics-associated features as novel diagnostic and/or
prognostic biomarkers. To pursue these interests, we used advanced culture models based on biomaterials
with tunable elasticity as well as Atomic force microscopy (AFM)
and other nanomechanical tools that enable measuring cell and tissue
mechanics with high resolution. Understanding the language of cell
shape in normal conditions and in tumors Intuitively, it is clear that there is a tight connection
between the shape of a cell and its specific biological functions, i.e. form
and function are expected to fit for every biological system. In support of
this connection, there are numerous examples that illustrate that both the
expression of most if not all genes and the activity of proteins are
regulated by the specific shape of the cell. The same principles apply to the
architecture of the extracellular matrix and how they support normal and
diseased conditions. However, our current understanding of how cell shape and
ECM structure and organization signal to regulate cellular processes is still
very poor. We take advantage of micropatterning and advanced imaging techniques and other engineering tools to
unravel how changes in cell shape and ECM architecture are transduced into
alterations in cellular processes. Nanobiotechnology and Bioengineering To understand how mechanical cues regulate cellular
functions in normal and diseased conditions, we take advantage of Atomic Force Microscopy and other nanotechniques that enable direct
mechanical manipulation of cells and tissues. For this purpose, we develop
new nanobiotechnological applications and optimize current systems to fit our
experimental needs. Experimental approaches and areas of expertise
Our research is intrinsically multidisciplinary, as it integrates tools and techniques from a
variety of scientific fields including molecular
and cell biology, biomaterials,
nanobiotechnology and biophysics. We conduct most of our experiments ‘ex-vivo’ using
cultured cells from soft tissues with a ductal-alveolar structure including lung and mammary tissue. The sources of our cells (both human and rodent)
are either primary culture from
donors or commercially available cell
lines. The main techniques we use in our research include the
following (but are not restricted to): · Cell
culture: primary culture of fibroblasts from tissue explants, culture of
cell lines of mesenchymal or epithelial origin · Genetic
tools for transcription manipulation: shRNA, siRNA · Biomaterials:
2D and 3D gel assays in which both the biochemical composition and the
mechanical properties can be controlled independently · Molecular
cell biology: qRT-PCR, Western-Blotting, Immunofluorescence,
Immunohistochemistry, Zymmography, Flow Cytometry · Tools
to control cell shape: micropatterning · Advanced
optical microscopy: phase contrast microscopy, DIC, epifluorescence, polarized
light microscopy, confocal microscopy and confocal reflection microscopy · Image
processing with Image J and Matlab · Digital
Pathology, with customized software to process histologic stainings from
patients · Bioinformatic
analysis, including analysis of gene expression datasets available at
TCGA or other databases, pathway enrichment analysis, interactome analysis
etc. · Nano-
Microrheology (i.e. characterization of mechanical properties of soft
samples, including cells, gels and tissues) with Atomic Force Microscopy ·
Control of Optical Microscopy setups ·
Digital Signal Processing and Data analysis with Matlab ·
Theoretical Physics: Soft Condensed Matter and Contact Mechanics |
UP
PUBLICATIONS
Microenvironment
in cancer and fibrosis Epigenetic
SMAD3 repression in tumor-associated fibroblasts impairs fibrosis and
response to the antifibrotic drug nintedanib in lung squamous cell carcinoma.
R. Ikemori, M. Gabasa, P. Duch, M. Vizoso, P. Bragado, M. Arshakyan, I-C.
Benchea, A. Marín, S. Morán, M. Castro, G. Fuster, S. Gea-Sorli, T. Jauset,
L. Soucek, L.M. Montuenga, M. Esteller, E. Monsó, V.I. Peinado, P. Gascón, C.
Fillat, F. Hilberg, N. Reguart, J. Alcaraz. Cancer Res 2020 80:276-290 LINK J. Alcaraz, J. Lluís Carrasco, L. Millares, I-C. Luis, F.J.
Fernández-Porras, A. Martinez-Romero, N. Diaz-Valdivia, J. Sanchez De Cos, R.
Rami-Porta, L. Seijo, J. Ramírez, M.J. Pajares, N. Reguart, E. Barreiro, E.
Monsó. Stromal markers of
activated tumor associated fibroblasts predict poor survival and are
associated with necrosis in non-small cell lung cancer. Lung Cancer 2019, 135: 151–160 LINK Esther Marhuenda,
Noelia Campillo, Marta Gabasa, Miguel Angel Martínez-García, Francisco
Campos-Rodríguez, David Gozal, Daniel Navajas, Jordi Alcaraz, Ramon Farré,
Isaac Almendros. Effects
of Sustained and Intermittent Hypoxia on Human Lung Cancer Cells. American Journal of Respiratory Cell and
Molecular Biology 2019 (in press) LINK Laura Sala, Héctor Franco-Valls, Jelena Stanisavljevic, Josue Curto,
Jordi Vergés, Raúl Peña, Paula Duch, Jordi Alcaraz, Antonio G. de Herreros
and Josep Baulida. Abrogation
of myofibroblast activities in metastasis and fibrosis by methyltransferase
inhibition. International Journal of
Cancer 2019 145:3064-3077 doi:
10.1002/ijc.32376. LINK A. Giménez, P. Duch, M. Puig, M. Gabasa, A.
Xaubet, J. Alcaraz. Dysregulated collagen homeostasis by matrix stiffening
and TGF-β1 in fibroblasts from idiopathic pulmonary fibrosis patients:
role of FAK/Akt. International Journal
of Molecular Science 2017, 18(11), 2431; pii: E2431 LINK M. Gabasa, P. Duch, I.
Jorba, A. Giménez, R. Lugo, I. Pavelescu, F. Rodríguez-Pascual, M.
Molina-Molina, A. Xaubet, J. Pereda, J. Alcaraz. Epithelial contribution to the pro-fibrotic
stiff microenvironment and myofibroblast population in lung fibrosis. Molecular Biology of the Cell 2017,
28(26):3741-3755 LINK M. Gabasa, R. Ikemori, F. Hilberg, N.
Reguart, J. Alcaraz. Nintedanib selectively inhibits the activation and
tumor-promoting effects of fibroblasts from lung adenocarcinoma patients. British Journal of Cancer 2017,
117:1128-1138 LINK A. Labernadie, T.
Kato, A. Brugués, X. Serra-Picamal, S. Derzsi, V. Gonzalez, A.
Elosegui-Artola, J. Alcaraz, P. Roca-Cusachs, E. Sahai, X. Trepat. A mechanically
active heterophilic E-cadherin/N-cadherin adhesion enables cancer associated
fibroblasts to drive cancer cell invasion. Nature Cell
Biology 2017, 19: 224–237 LINK R. Lugo, M. Gabasa, F. Andriani, M. Puig, F.
Facchinetti, J. Ramírez, A. Gómez-Caro, U. Pastorino, G. Fuster, I.
Almendros, P. Gascón, A. Davalos, N. Reguart, L. Roz, J. Alcaraz. Heterotypic
paracrine signaling drives fibroblast senescence and tumor progression of
large cell carcinoma of the lung. Oncotarget 2016 7(50):82324-82337 LINK M. Vizoso, M. Puig, F.J. Carmona, M. Maqueda, A.
Velásquez, A. Gómez, A. Labernadie, R. Lugo, M. Gabasa, L.G.
Rigat-Brugarolas, X. Trepat, J. Ramírez, N. Reguart, S. Moran, A. Perera, M.
Esteller, J. Alcaraz. Aberrant DNA methylation in Non Small
Cell Lung Cancer associated fibroblasts. Carcinogenesis 2015, 36:1453-63 LINK E. Monsó, L.M. Montuenga, J. Sánchez de Cos, C.
Villena, and Grupo Colaborativo en Cáncer de Pulmón CIBERES-RTICC-SEPAR-Plataforma
Biobanco Pulmonar (J. Alcaraz et al.), Biological Marker Analysis as Part of
the CIBERES-RTIC Cancer-SEPAR Strategic Project on Lung Cancer. Arch Bronconeumol,
2015 51(9):462-467 LINK V. Vicens-Zygmunt, S. Estany, A. Colom, A.
Montes-Worboys, C. Machahua, A.J. Sanabria, R. Llatjos, I. Escobar, F. Manresa,
J. Dorca, D. Navajas, J. Alcaraz, M. Molina-Molina. Fibroblast
viability and phenotypic changes within glycated stiffened three-dimensional
collagen matrices. Respiratory Research 2015
Jul 1;16:82 LINK M. Puig, R. Lugo, M. Gabasa, A. Giménez, A. Velásquez,
R. Galgoczy, J. Ramírez, A. Gómez-Caro, Ó. Busnadiego, F. Rodríguez-Pascual, P.
Gascón, N. Reguart, J. Alcaraz. Matrix Stiffening and Beta1 integrin
Drive Subtype-specific Fibroblast Accumulation in Lung Cancer. Mol Cancer Res 2015, 13:161-73. LINK Mori H, Lo AT, Inman JL, Alcaraz J, Ghajar CM, Mott JD, Nelson CM, Chen
CS, Zhang H, Bascom JL, Seiki M, Bissell MJ. Transmembrane/cytoplasmic,
rather than catalytic, domains of Mmp14 signal to MAPK activation and mammary
branching morphogenesis via binding to integrin β1. Development. 2013, 140:343-52
LINK I.
Acerbi, T. Luque, A. Giménez, M.
Puig, N. Reguart, R. Farré, D.
Navajas, and J. Alcaraz. Integrin-Specific Mechanoresponses to Compression and Tension Probed
by cylindrical Flat-Ended AFM Tips in Lung Cells. PLoS ONE 2012, 7: e32261
LINK J. Alcaraz, H. Mori, C.M. Ghajar, D. Brownfield,
R. Galgoczy and M.J. Bissell. Collective epithelial cell invasion overcomes
mechanical barriers of collagenous extracellular matrix by a narrow tube-like
geometry and MMP14-dependent local softening. Integr. Biol.,
2011, 3:1153–1166 LINK I. Acerbi, J. Pereda, M. Molina-Molina, D. Navajas, N.
Reguart, J. Alcaraz. TGF-beta1
stiffens lung carcinoma cells in culture. J Thorac Oncol. 2009, 4:S602-S603 LINK J. Alcaraz, R. Xu, H. Mori, C.M. Nelson, R.
Mroue, V.A. Spencer, D. Brownfield, D.C. Radisky, C. Bustamante, M.J.
Bissell. Laminin and
biomimetic extracellular elasticity enhance functional differentiation in
mammary epithelia EMBO J. 2008,
27:2829-2838 LINK J. Alcaraz, C.M. Nelson, M.J. Bissell. Biomechanical
Approaches For Studying Integration of Tissue Structure and Function In
Mammary Epithelia. J Mammary Gland Biol Neoplasia. 2004, 9:361-374 LINK Understanding the
language of cell shape J. Alcaraz, H. Mori, C.M. Ghajar, D. Brownfield, R. Galgoczy and M.J.
Bissell. Collective epithelial cell
invasion overcomes mechanical barriers of collagenous extracellular matrix by
a narrow tube-like geometry and MMP14-dependent local softening. Integr. Biol., 2011, 3:1153–1166 LINK P. Roca-Cusachs, J. Alcaraz,
R. Sunyer, J. Samitier, R. Farré, D. Navajas. Micropatterning
of single endothelial cell shape reveals a tight coupling between nuclear
volume in G1 and proliferation. Biophys J, 2008, 94:4984-4995 LINK J. LeBeyec, R.
Xu, S.Y. Moonlee, C.M. Nelson, A. Rizki, J. Alcaraz, M.J. Bissell. Cell shape regulates global histone
acetylation in human mammary epithelial cells. Exp Cell Res. 2007,313:3066-3075 LINK Nanobiotechnology and
Bioengineering Characterization
of the elastic properties of extracellular matrix models by atomic force
microscopy. J. Otero, D. Navajas, J. Alcaraz. Methods in Cell Biology:
Cell-derived Matrices Part A 2019 doi.org/10.1016/bs.mcb.2019.11.016 LINK J. Alcaraz, J. Otero,
I. Jorba, D. Navajas. Bidirectional
mechanobiology between cells and their local extracellular matrix probed by
atomic force microscopy. Seminars in
Cell and Developmental Biology 2017, S1084-9521(17)30328-2 LINK A. Giménez, J.J Uriarte, J. Vieyra, D. Navajas, J.
Alcaraz. Elastic properties
of hydrogels and decellularized tissue sections used in mechanobiology
studies probed by atomic force microscopy. Microsc Res Tech. 2017;80:85-96. LINK R. Galgoczy, I. Pastor, A. Coloma, A. Giménez, F. Mas,
J. Alcaraz. A spectrophotometer-based diffusivity
assay reveals that diffusion hindrance of small molecules in extracellular
matrix gels used in 3D cultures is dominated by viscous effects. Colloids and Surfaces B: Biointerfaces
2014, 120:200-7 LINK Colom
A, Galgoczy R, Almendros I, Xaubet A, Farré R, Alcaraz J. Oxygen diffusion
and consumption in extracellular matrix gels: Implications for designing
three-dimensional cultures. J Biomed
Mater Res A. 2014, 102:2776-84
LINK I. Acerbi, T. Luque, A. Giménez, M. Puig, N. Reguart, R. Farré, D. Navajas, and J. Alcaraz. Integrin-Specific
Mechanoresponses to Compression and Tension Probed by cylindrical Flat-Ended
AFM Tips in Lung Cells. PLoS
ONE 2012, 7: e32261 LINK F. Rico, J. Alcaraz, J.J.
Fredberg, D. Navajas. Nanomechanics
of lung epithelial cells. Int J of Nanotechnology. 2005, 2:180-194 LINK J. Alcaraz, L. Buscemi, X. Trepat, M. Grabulosa, B. Fabry,
R Farré, D. Navajas. Microrheology of cultured
lung epithelial cells measured with Atomic Force Microscopy. Biophys J. 2003,
84:2071-79 LINK J. Alcaraz, L. Buscemi, M. Puig-de-Morales, J. Colchero, A. Baró, D. Navajas. Correction of
Microrheological Measurements of Soft Samples with Atomic Force Microscopy
for the hydrodynamic Drag on the Cantilever. Langmuir. 2002, 18: 716-721 LINK M. Puig-de-Morales, M. Grabulosa, J.
Alcaraz, J. Mullol, G.N.
Maksym, J.J. Fredberg, D. Navajas. Microrheology of cultured
airway epithelial cells measured by magnetic twisting cytometry with
frequency domain demodulation. J.Appl.Physiol. 2001, 91: 1152-1159 LINK D. Navajas, J. Alcaraz, R.
Peslin, J. Roca, R. Farré. Evaluation of a method
for assessing respiratory mechanics during non-invasive ventilation. Eur. Respir. J. 2000, 16: 704-709 LINK Book chapters J. Alcaraz, P.
Roca-Cusachs. Shape and Mechanical Cues Underlying Cellular
Homeostasis in Soft Organs. Chapter of Cells, Forces and the
Microenvironment (English). Coordinated by C. M. Cuerrier and A.E.
Pelling. Published by Pan Stanford and World Scientiphic Publishing (US), 2015. ISBN: 978-981-4613-36-1 LINK J. Alcaraz. Microscopía de Fuerza Atómica. Chapter of Técnicas en Histología y
Biología celular (Spanish). Coordinated by L. Montuenga. Published by
Elsevier (Spain), 2014. ISBN: 978-84-458-2520-4 LINK J. Alcaraz. Introducción a las aplicaciones biofarmacológicas y
biotecnológicas de la bioingeniería. Chapter of Biotecnología y Biofármacos.
Módulo II (Spanish). Coordinated by J. Piulats. Published by Plan
Nacional de Formación Continuada. Consejo General de Colegios
Oficiales de Farmacéuticos (Spain). 2010. ISBN: 978-84-693-1789-1 Legal Deposit:
M-20075-2010 |
UP
COLLABORATION WITH
BIOMEDICAL INDUSTRY
• Boheringer-Ingelheim, Spain LINK
• Boheringer-Ingelheim Inc., Austria LINK
• Basilea Pharmaceutica, Switzerland
• Artidis, Switzerland
• Peptomyc, Spain
NEWS AND VIEWS
ON OUR WORK
Research collaboration with Boehringer-Ingelheim Inc
Austria, 2019 LINK Research collaboration with Boehringer-Ingelheim Spain,
2015 LINK Crowdfunding campaing: “New approaches in the fight
against lung cancer”, 2014 LINK Cover of the 12th issue of the journal of the Royal Society of Chemistry iBiology displays an
image from our iBiology 2011 paper LINK Nomination of our EMBO
J 2008 by the Faculty of 1000 Biology LINK |
COLLABORATORS
· Research Groups
(in alphabetic order):
Mina J Bissell, LBNL, Berkeley (US) Albert Davalos, Buck Institute for Age Research,
Novato (US) Manel Esteller, PEBC, IDIBELL, Barcelona (Spain) Pere Gascón, IDIBAPS, Barcelona (Spain) Eduard Monsó, Hospital Parc Taulí, CIBERES,
Sabadell (Spain) Alexandre Perera, UPC, CREB, Barcelona (Spain) Noemi Reguart, IDIBAPS, Barcelona (Spain) Luca Roz, Istituto Nazionale dei Tumori,
Milano (Italy) Valerie Weaver, UCSF, San Francisco (US) Derek Radisky, Mayo Clinic, Jacksonville FL (US) Xavier Trepat, IBEC, Barcelona (Spain) Josep Samitier, IBEC, Barcelona (Spain) · Clinical & Biomedical Institutions Functional Unit of Thoracic Tumors,
Hospital Clínic, Barcelona (Spain) Pathology Department, Hospital
Clínic, Barcelona (Spain) |
DONAR SUPORT RECERCA CÀNCER DE PULMÓ
SUPPORT LUNG CANCER RESEARCH
El nostre grup de recerca accepta
aportacions voluntàries per ajudar a finançar la seva recerca en càncer de pulmó.
Per fer-ho, es prega contactar amb
l’investigador principal del grup (Jordi Alcaraz) per email (jalcaraz@ub.edu) o telèfon (93 403 1148). Així
mateix, podeu també contactar-nos per a qualsevol dubte o inquietud relacionada
amb la nostra recerca!
Podeu contribuir amb qualsevol
aportació o fent difusió de la nostra recerca.
Moltes gràcies!
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Our research group accepts volunteer
donations to support our lung cancer research. For this purpose, please contact
the principal investigator of this group (Jordi Alcaraz) by email (jalcaraz@ub.edu) or telephone (+3493 403
1148). Likewise, should you have any doubt or different request on our research,
please contact us!
You can help us by making a donation or
spreading the word of our research.
Many thanks!
TEACHING
We are actively involved in the
following academic programs: · Degree in
Medicine, UB · Degree in
Molecular Medicine, UB · Degree in
Biomedical Engineering, UB · Master in Biomedical
Engineering, UB, UPC · Master in Biomedicine, UB · Master in Pharmaceutical Industry and
Biotechnology, UPF · Bioengineering in the Pharmaceutical
and Biotechnological Industry, IL3, UB |
OPENINGS FOR
MASTER STUDENTS, GRAD STUDENTS AND POSTDOCS
Our group is continuously open to students at the level of
Master, Graduate (PhD) and Postdoctoral level. Please contact us to inquire about currently available
positions and projects. |
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GROUP PICTURES |
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Christmas
2009 |
Christmas
2010 |
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CONTACT
· email · Phone [Office Ph: (+34) 93 403 1148] [Lab Ph: (+34) 934039764] [Fax: (+34) 934035278] · Office and Lab location Unitat de Biofísica i Bioenginyeria 5th floor, Facultat de Medicina (School of Medicine) Casanova 143, Barcelona |
