Isaac Almendros, Ph.D.

 

Assistant professor, Unit of Biophysics and Bioengineering, Department of Physiological Sciences I, School of Medicine, University of Barcelona, Spain.

 

 

 

Editor reviewer of Frontiers in Neurology: Sleep and Chronobiology Journal

Member of the College of Experts of European Respiratory Society.

Member of the Early Career Network of American Journal of Respiratory and Critical Care of Medicine.

 

* isaac.almendros@ub.edu

( +(34) 934024515

 

IMG_9873

 

 

 

Teaching

 

Degree in Medicine, School of Medicine, University of Barcelona.

Degree in Biomedical Engineering, School of Medicine, University of Barcelona.

Master in Biomedical Engineering, University of Barcelona – Polytechnic University of Catalonia

Ph.D. on Biomedicine. University of Barcelona.

 

 

Equipment

 

Atomic Force Microscopy

Magnetic Tweezers

Cell stretching

Surface Micro/Nano-patterning

Live cell fluorescence microscopy

Traction Microscopy

Cell culture

Respiratory mechanics techniques

Animal models of mechanical ventilation

Animal models of obstructive sleep apnea

Bone marrow-derived mesenchymal stem cells

Murine embryonic stem cells

 

 

Recent publications

 

1.            Cortese R, Almendros I, Wang Y, Gozal D. Microarray-based analysis of plasma cirDNA epigenetic modification profiling in xenografted mice exposed to intermittent hypoxia. Genomics Data 2015;5:17–20.

2.            Almendros I*, Montserrat JM, Campos-Rodriguez F, Farre R. Apnea del Sueño y Cáncer: Evidencias Clínicas y Biológicas. Medicina respiratoria (in press). *Corresponding author

3.            Almendros I, Gileles-Hillel A, Khalyfa A, Wang Y, Zhang SX, Carreras A, Farré R, Gozal D. Adipose tissue macrophage polarization by intermittent hypoxia in a mouse model of OSA: Effect of tumor microenvironment. Cancer Lett. 2015;361:233-9.

4.            da Palma RK, Farré R, Montserrat JM, Gorbenko Del Blanco D, Egea G, de Oliveira LV, Navajas D, Almendros I*. Increased upper airway collapsibility in a mouse model of Marfan syndrome. Respir Physiol Neurobiol. 2015 Feb 1;207:58-60. *Corresponding author.

5.            Martínez-García MA, Campos-Rodríguez F, Almendros I, Farré R. Relación entre apnea del sueño y cáncer. Arch Bronconeumol. 2015. (In press).

6.            Cortese R, Almendros I, Wang Y, Gozal D. Tumor circulating DNA profiling in xenografted mice exposed to intermittent hypoxia. Oncotarget. 2015 Jan 1;6(1):556-69.

7.            Carreras A, Zhang SX, Peris E, Qiao Z, Wang Y, Almendros I, Gozal D. Resveratrol Attenuates Intermittent Hypoxia-Induced Macrophage Migration to Visceral White Adipose Tissue and Insulin Resistance in Mouse. Endocrinology. 2015 Feb;156(2):437-43.

8.            Zheng J, Almendros I, Wang Y, Zhang SX, Carreras A, Qiao Z, Gozal D. Reduced NADPH Oxidase Type 2 Activity Mediates Sleep Fragmentation-Induced Effects on TC1 Tumors in Mice. Oncoimmunology. 2015 Mar 6;4(2):e976057.

9.            Carreras A, Zhang SX, Peris E, Qiao Z, Wang Y, Almendros I, Gozal D. Effect of Resveratrol on Visceral White Adipose Tissue Inflammation and Insulin Sensitivity in a Mouse Model of Sleep Apnea. Int J Obes (Lond). 2015;39(3):418-23.

10.         Khalyfa A, Carreras A, Almendros I, Hakim F, Gozal D. Gender Dimorphism in Late Gestational Sleep Fragmentation and Metabolic Dysfunction In Offspring Mice. Sleep. 2015 Apr 1;38(4):545-57.

11.         Gileles-Hillel A, Almendros I, Khalyfa A, Zhang SX, Wang Y, Gozal D. Early intermittent hypoxia induces proatherogenic changes in aortic wall macrophages in a murine model of OSA. Am J Respir Crit Care Med. 2014;190(8):958-61.

12.         Gozal D, Almendros I, Hakim F. Sleep apnea awakens cancer: A unifying immunological hypothesis. Oncoimmunology. 2014 27;3:e28326. eCollection 2014.

13.         Almendros I, Wang Y, Gozal D. The polymorphic and contradictory aspects of intermittent hypoxia. Am J Physiol Lung Cell Mol Physiol. 2014; 307(2):L129-40.

14.         Hakim F, Wang Y, Zhang SXL, Zheng J, Yolcu ES, Carreras A, Khlayfa A, Shirwan H, Almendros I, Gozal D. Fragmented sleep induces accelerated tumor growth and invasiveness via recruitment of tumor-associated macrophages and TLR4 signaling in mice. Cancer Res. 2014; 74(5):1329-37.

15.         Almendros I, Wang Y, Becker L, Lennon FE, Zheng, J, Coats BR, Schoenfelt KS, Carreras A, Hakim F, Zhang SX, Farre R, Gozal D. Intermittent hypoxia-induced changes in tumor-associated macrophages and tumor malignancy in murine sleep apnea model. Am J Respir Crit Care Med. 2014; 189(5):593-601.

16.         Pablo Ramos P, Rubies C, Marta Torres M, Montserrat Batlle M, Farre R, Montserrat JM, Almendros I*, Mont L*. Atrial fibrosis in a chronic murine model of obstructive sleep apnea. Mechanisms and prevention by mesenchymal stem cells. Respir Res. 2014;15:54. *Equal contributors.

17.         Dalmases M, Planas A, Torres M, Marquez-Kisinousky L, Almendros I, Embid C, Martinez MA, Farre R, Montserrat JM .Obstructive sleep apneas induce lower brain oxidative stress in old tan in youn rats. Sleep. 2014 Jul 1;37(7):1249-56.

18.         Colom A, Galgoczy R, Almendros I, Xaubet A, Farré R, Alcaraz J. Oxygen diffusion and consumption in extracellular matrix gels: Implications for designing three-dimensional cultures. J Biomed Mater Res A. 2014;102(8):2776-84..

19.         Almendros I, Montserrat JM, Torres M, Dalmases M, Cabañas ML, Campos-Rodríguez F, Navajas D, Farré R. Intermittent hypoxia increases melanoma metastasis to the lung in a mouse model of sleep apnea. Respir Physiol Neurobiol. 2013;186:303-7.

20.         Almendros I, Montserrat JM, Torres M, Bonsignore MR, Chimenti L, Navajas D, Farre R. Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea. Sleep Med. 2012;13:1254-60.

21.         Almendros I, Carreras A, Montserrat JM, Gozal D, Farre R. Potential role of adult stem cells in obstructive sleep apnea. Front Neurol. 2012;3:112.

22.         Almendros I, Montserrat JM, Ramírez J, Torres M, Duran-Cantolla J, Navajas D, Farré R. Intermittent hypoxia enhances cancer progression in a mouse model of obstructive sleep apnea. Eur Respir J. 2012 Jan;39(1):215-7.

23.         Almendros I, Farré R, Torres M, Bonsignore MR, Ramírez J, Navajas D, Montserrat JM. Early and mid-term effects of obstructive apneas in myocardial injury and inflammation. Sleep Med. 2011;12:1037-40.

24.         Almendros I, Farré R, Planas AM, Torres M, Bonsignore MR, Navajas D, Montserrat JM. Tissue oxygenation in brain, muscle and fat in a rat model of sleep apnea; Differential effect of obstructive apneas and intermittent hypoxia. Sleep 2011;34:1127-33.

25.         Carreras A, Almendros I, Farré R. Potential role of bone marrow mesenchymal stem cells in obstructive sleep apnea. International Journal of Mesenchymal Stem Cells 2011; 4: 43-9

26.         Carreras A, Almendros I, Montserrat JM, Navajas D, Farré R. Mesenchymal stem cells reduce inflammation in a rat model of obstructive sleep apnea. Respir Physiol Neurobiol. 2010;172:210-2.

27.         Martínez-Vidal BM, Farre R, Montserrat JM, Torres M, Almendros I, Aguilar F, Embid C, Vilaseca I. Effects of Heated Humidification on nasal inflammation in a CPAP experimental rat model. Sleep Medicine 2010;11:413-6.

28.         Almendros I, Montserrat JM, Torres M, González C, Navajas D, Farré R. Changes in oxygen partial pressure of brain tissue in an animal model of obstructive apnea. Respir Res. 2010 15:11:3.

29.         Carreras A, Almendros I, Acerbi I, Montserrat JM, Navajas D, Farré R. Obstructive apneas induce early release of mesenchymal stem cells into circulating blood. Sleep 2009;32:117-9.

30.         Almendros I, Carreras A, Ramírez J, Montserrat JM, Navajas D, Farré R. Upper airway collapse and reopening induce inflammation in a sleep apnoea model. Eur Respir J. 2008;32:399-404.

31.         Almendros I, Gutierrez PT, Closa D, Navajas D, Farre R. One-lung overventilation does not induce inflammation in the normally ventilated contralateral lung. Respir Physiol Neurobiol. 2008;162:100-2.

32.         Almendros I, Acerbi I, Vilaseca I, Monserrat JM, Navajas D, Farre R. Continuous positive airway pressure (CPAP) induces early nasal inflammation. Sleep. 2008;31:127-31.

33.         Almendros I, Acerbi I, Puig F, Monserrat JM, Navajas D, Farre R. Upper-Airway Inflammation Triggered by Vibration in a Rat Model of Snoring. Sleep. 2007;30:225-227.

34.         Roca-Cusachs P, Almendros I, Sunyer R, Gavara N, Farre R, Navajas D. Rheology of passive and adhesion-activated neutrophils probed by Atomic Force Microscopy. Biophys J. 2006;91:3508-3518.

35.         Puig F, Rico F, Almendros I, Montserrat JM, Navajas D, Farre R. Vibration enhances interleukin-8 release in a cell model of snoring-induced airway inflammation. Sleep 2005;28:1312-1316.